Prohibitin Antibody (6K2D1): sc-53996
- Prohibitin Antibody (6K2D1) is a mouse monoclonal IgG1 provided at 200 µg/ml
- recommended for detection of Prohibitin of human origin by IP
- See Prohibitin (E-5): sc-377037 for Prohibitin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Prohibitin Antibody (6K2D1). This work is in progress.
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Prohibitin Antibody (6K2D1) is a mouse monoclonal IgG1 antibody that detects prohibitin in human samples through immunoprecipitation (IP). Prohibitin is an evolutionarily conserved protein known for antiproliferative activity and plays a crucial role in regulating the cell cycle by blocking the transition between G1 and S phases. Prohibitin (6K2D1) antibody targets a protein predominantly localized in the inner membrane of mitochondria, where anti-prohibitin antibody (6K2D1) influences mitochondrial function and acts as a potential tumor suppressor by binding to retinoblastoma (Rb) and inhibiting E2F family members in response to specific signaling pathways. Additionally, prohibitin is involved in B cell maturation, as prohibitin monoclonal antibody (6K2D1) detects expression on the plasma membrane of B cells. Prohibitin mRNA and protein levels fluctuate throughout the cell cycle, peaking in G1, declining during S phase, and rising again in G2, indicating regulatory roles through both transcriptional and post-translational mechanisms. Notably, mutations in prohibitin genes have been linked to breast cancer development and progression in over 80% of analyzed cell lines, highlighting significance in cancer biology. Anti-prohibitin antibody (6K2D1) serves as an essential tool for researchers investigating prohibitin′s intricate roles in cellular processes and cancer research.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Prohibitin Antibody (6K2D1) | sc-53996 | 200 µg/ml | $322.00 |