Prealbumin Antibody (10E1): sc-69794

Prealbumin Antibody (10E1) is a mouse monoclonal IgG2a antibody that detects Prealbumin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Prealbumin, also known as transthyretin, plays a crucial role in the transport of thyroid hormones, particularly thyroxine, from the bloodstream to the brain, which is vital for maintaining proper neurological function and development. Prealbumin is predominantly located in the cytoplasm and vesicles of developing brain cells, where Prealbumin is believed to be taken up from the cerebrospinal fluid via endocytosis, highlighting Prealbumin′s importance in cellular transport mechanisms. Sequence variants of Prealbumin have been implicated in the formation of amyloid fibrils associated with familial amyloidotic polyneuropathy, a hereditary systemic amyloidosis, emphasizing the significance of Prealbumin′s structural integrity. While the biologically active form of Prealbumin exists as a tetramer, the amyloidogenic intermediate is thought to exist as a monomer, which underscores the importance of understanding Prealbumin′s structural dynamics in disease contexts. Prealbumin interacts with retinol-binding protein, further illustrating Prealbumin′s multifaceted role in the transport of essential molecules. The gene encoding Prealbumin is located on human chromosome 18q12.1, making Prealbumin a critical target for research in both normal physiology and pathological conditions. Anti-Prealbumin antibody (10E1) serves as an essential tool for researchers investigating the functions and implications of Prealbumin.

The preferred Prealbumin antibody is Prealbumin Antibody (E-1): sc-377517.