Placental lactogen I Antibody (C-12): sc-376436

Placental lactogen I Antibody (C-12) is a mouse monoclonal IgM antibody that detects Placental lactogen I of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Placental lactogen I antibody (C-12) is available as the non-conjugated form. Placental lactogen I, a member of the somatotropin/prolactin family of hormones, plays a critical role in regulating maternal metabolism and fetal development during pregnancy. Placental lactogen I is primarily expressed during mid-pregnancy and is essential for ensuring successful lactation post-delivery. Placental lactogen I expression is intricately regulated by DNA methylation, particularly in rats, which highlights the importance of epigenetic mechanisms in controlling activity. Placental lactogen I interacts with various growth factors, influencing the metabolic state of the mother to provide necessary energy to the developing fetus. Understanding the function and regulation of Placental lactogen I is vital, as Placental lactogen I not only supports fetal growth but also modulates maternal physiological adaptations during pregnancy, making Placental lactogen I a key player in reproductive health.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Placental lactogen I Antibody (C-12) References:

1. DNA methylation regulates placental lactogen I gene expression.  |  Cho, JH., et al. 2001. Endocrinology. 142: 3389-96. PMID: 11459782
2. Endocrinology of lactation.  |  Buhimschi, CS. 2004. Obstet Gynecol Clin North Am. 31: 963-79, xii. PMID: 15550345
3. [Placental proteins and protein hormones in high risk pregnancies].  |  Sulovic, V. 2002. Glas Srp Akad Nauka Med. 1-19. PMID: 16078438
4. Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta.  |  Lambot, N., et al. 2005. Mol Cell Endocrinol. 243: 80-5. PMID: 16226369
5. Evaluation of beta-cell replication in mice transgenic for hepatocyte growth factor and placental lactogen: comprehensive characterization of the G1/S regulatory proteins reveals unique involvement of p21cip.  |  Cozar-Castellano, I., et al. 2006. Diabetes. 55: 70-7. PMID: 16380478
6. The role of nitric oxide in the peripheral vasoconstriction caused by human placental lactogen in anaesthetized pigs.  |  Molinari, C., et al. 2006. Exp Physiol. 91: 603-10. PMID: 16513823
7. Human placental lactogen is a first-trimester maternal serum marker of Down syndrome.  |  Christiansen, M., et al. 2007. Prenat Diagn. 27: 1-5. PMID: 17154235
8. Ontogeny of placental lactogen-I and placental lactogen-II expression in the developing rat placenta.  |  Faria, TN., et al. 1990. Dev Biol. 141: 279-91. PMID: 2210037
9. Production of mouse placental lactogen-I by trophoblast giant cells in utero and in vitro.  |  Nieder, GL. and Jennes, L. 1990. Endocrinology. 126: 2809-14. PMID: 2351096
10. Co-localization of placental lactogen-I, placental lactogen-II, and proliferin in the mouse placenta at midpregnancy.  |  Yamaguchi, M., et al. 1994. Biol Reprod. 51: 1188-92. PMID: 7888496
11. Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter.  |  Shida, MM., et al. 1993. Mol Endocrinol. 7: 181-8. PMID: 8469232
12. Calcyclin in the mouse decidua: expression and effects on placental lactogen secretion.  |  Farnsworth, RL. and Talamantes, F. 1998. Biol Reprod. 59: 546-52. PMID: 9716552

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Placental lactogen I Antibody (C-12) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Placental lactogen I Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Placental lactogen I Antibody (C-12) Specifications

Alternate Product Name: Placental lactogen I

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 41-75

Epitope Target: Placental lactogen I

Epitope Species: mouse

Product Reactivity/Detection: precursor and mature Placental lactogen I

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Placental lactogen I Antibody (C-12): P: Blocking Peptide