Pitavastatin Calcium CAS: 147526-32-7
MF: C50H46CaF2N2O8
MW: 880.98
A competitive inhibitor of HMG-CoA reductase.

Pitavastatin Calcium (CAS 147526-32-7)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Pitavastatin Calcium is rated 5.0 out of 5 by 2.
5
2
4
0
3
0
2
0
1
0
备用名: Pitavastatin hemicalcium; Nisvastatin
应用; Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase
CAS号码: 147526-32-7
纯度: ≥98%
分子量: 880.98
分子式: C50H46CaF2N2O8
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.


参考文献

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).
保存 :
Store at room temperature
沸点 :
692° C at 760 mmHg
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
5282451
SMILES :
O[[email protected]](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[[email protected]@H](O)CC(=O)O[Ca]OC(=O)C[[email protected]](O)C[[email protected]](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

下载SDS

分析证明书

在PDF文件上阅读,打印和批注,Adobe阅读器是必须的

Pitavastatin Calcium (CAS 147526-32-7)  产品相关文献索引

看其他用户如何应用Pitavastatin Calcium (CAS 147526-32-7).点击进入浏览PubMed条目 .

引用1 - 77

PMID: # 25993292  Yoshimura, K. et al. 2015. Int J Mol Sci. 16: 11213-28.

PMID: # 24671957  Chang, JH. et al. 2014. Drug Metab. Dispos. 42: 1067-73.

PMID: # 23750830  Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.

PMID: # 23564645  Zhang, X. et al. 2013. Toxicological sciences : an official journal of the Society of Toxicology. 134: 73-82.

PMID: # 31772607  Cardiovasc Ther. 2019: 2549432.

PMID: # 31527323  J. Atheroscler. Thromb. 27: 429-440.

PMID: # 32435188  Front Pharmacol. 469.

引用1 - 77
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 110ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

圣克鲁斯生物技术在生物医药研究市场的产品开发方面处于世界领先地位。欢迎 致电我们的免费电话(021) 800-820-8626。 版权 ©, 2007-2021圣克鲁斯生物技术。版权所有。“Santa Cruz Biotechnology”,圣克鲁斯生物技 术的 商标,“Santa Cruz Animal Health”,“San Juan Ranch”,“Supplement of Champions”,San Juan Ranch的商标,“Ultracruz”,“Chemcruz”,“Immunocruz”,“Exactacruz”和“EZ Touch”都是圣克鲁斯生物技术的注册商标。所有的商标都归其各自拥有者所有。