Pitavastatin Calcium (CAS 147526-32-7)

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备用名: Pitavastatin hemicalcium; Nisvastatin

应用； Pitavastatin Calcium is a competitive inhibitor of HMG-CoA reductase

CAS号码: 147526-32-7

纯度: ≥98%

分子量: 880.98

分子式: C₅₀H₄₆CaF₂N₂O₈

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.

参考文献

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).

保存 :

Store at room temperature

沸点 :

692° C at 760 mmHg

仅供科研使用。不可用于诊断或治疗。

PubChem CID :

5282451

SMILES :

O[[email protected]](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[[email protected]@H](O)CC(=O)O[Ca]OC(=O)C[[email protected]](O)C[[email protected]](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

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