Date published: 2025-9-10
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PINK1 Antibody (38CT20.8.5) - Western Blotting - Image 384286
PINK1 抗体 (38CT20. 8. 5): sc-517353. A-431 (A) 和 Sol8 (B) 全细胞裂解液中 PINK1 表达的 Western 印迹分析.
PINK1 Antibody (38CT20.8.5) - Western Blotting - Image 384286
PINK1 抗体 (38CT20. 8. 5): sc-517353. A-431 (A) 和 Sol8 (B) 全细胞裂解液中 PINK1 表达的 Western 印迹分析.
PINK1 抗体 (38CT20. 8. 5): sc-517353. A-431 (A) 和 Sol8 (B) 全细胞裂解液中 PINK1 表达的 Western 印迹分析.

PINK1 抗体 (38CT20.8.5): sc-517353

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说明书
  • PINK1 抗体 38CT20.8.5 是小鼠单克隆 IgG1 κ，PINK1抗体, 在79篇文献中引用，规格为50 µg/0.5 ml
  • 用与human来源的PINK1相对应的重组蛋白进行免疫
  • PINK1 抗体 (38CT20.8.5) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 PINK1
  • 关于如何获取PINK1 (38CT20.8.5): sc-517353的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 PINK1 抗体 (38CT20.8.5) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与PINK1 抗体 (38CT20.8.5) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

PINK1抗体（38CT20.8.5）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）检测小鼠、大鼠和人类来源的PINK1蛋白。抗PINK1抗体（38CT20.8.5）可作为非结合单克隆抗体使用。（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）检测小鼠、大鼠和人类来源的PINK1蛋白。抗PINK1抗体（38CT20.8.5）可作为非结合单克隆同种型抗体使用。PINK1，即PTEN诱导假定激酶1，是丝氨酸/苏氨酸蛋白激酶家族的重要成员，具有肿瘤抑制功能。PINK1主要定位于线粒体，在维持线粒体的完整性和功能方面发挥着重要作用。PINK1在线粒体中的存在有助于保护细胞免受线粒体功能障碍的影响，特别是在细胞压力下，通过磷酸化线粒体蛋白质来促进能量产生和细胞凋亡调节。PINK1基因（PARK6）的突变会导致自磷酸化活性改变，而自磷酸化活性改变与早发性帕金森病有关，这是一种以运动症状（如静止性震颤和僵硬）为特征的神经退行性疾病。PINK1在睾丸、骨骼肌和心脏等组织中的广泛表达凸显了其在各种生理过程中的重要性，而在胰腺和大脑等组织中的低表达则突出了其在细胞健康和疾病中的特殊作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PINK1 参考文献:

  1. 参与 PTEN 信号通路的两个基因 BPOZ 和 EGR2 的生长抑制作用。  |  Unoki, M. and Nakamura, Y. 2001. Oncogene. 20: 4457-65. PMID: 11494141
  2. 由 PINK1 基因突变引起的遗传性早发性帕金森病。  |  Valente, EM., et al. 2004. Science. 304: 1158-60. PMID: 15087508
  3. 导致 PARK6 帕金森病的基因 PINK1 并不影响常见形式的帕金森病。  |  Healy, DG., et al. 2004. Ann Neurol. 56: 329-35. PMID: 15349859
  4. 早发性帕金森病中的新型 PINK1 基因突变。  |  Hatano, Y., et al. 2004. Ann Neurol. 56: 424-7. PMID: 15349870
  5. 对一大批帕金森病患者的 PINK1 基因进行分析。  |  Rogaeva, E., et al. 2004. Arch Neurol. 61: 1898-904. PMID: 15596610
  6. 与隐性帕金森症有关的 PINK1 突变体的线粒体输入和酶活性。  |  Silvestri, L., et al. 2005. Hum Mol Genet. 14: 3477-92. PMID: 16207731
  7. 台湾一组散发性早发帕金森症患者的 PINK1 基因分析。  |  Fung, HC., et al. 2006. Neurosci Lett. 394: 33-6. PMID: 16257123
  8. PINK1功能的丧失通过影响氧化应激和线粒体分裂来促进线粒体自噬。  |  Dagda, RK., et al. 2009. J Biol Chem. 284: 13843-13855. PMID: 19279012
  9. PINK1 磷酸化 Drp1S616，调节线粒体的有丝分裂依赖性动态。  |  Han, H., et al. 2020. EMBO Rep. 21: e48686. PMID: 32484300
  10. 以ATAD3A-PINK1-mitophagy轴为靶点，通过将PD-L1重定向至线粒体，克服化疗免疫疗法的耐药性。  |  Xie, XQ., et al. 2023. Cell Res. 33: 215-228. PMID: 36627348
  11. Optineurin：自噬的联系。  |  Nguyen, TN., et al. 2023. Mol Cell. 83: 1693-1709.e9. PMID: 37207627
  12. PINK1和Parkin调节IP3R介导的ER钙释放。  |  Ham, SJ., et al. 2023. Nat Commun. 14: 5202. PMID: 37626046

订购信息

产品名称产品编号规格价格数量收藏夹

PINK1 抗体 (38CT20.8.5)

sc-517353
50 µg/0.5 ml
$316.00

PINK1 (38CT20.8.5): m-IgG Fc BP-HRP 套装

sc-541103
50 µg Ab; 10 µg BP
$354.00

PINK1 (38CT20.8.5): m-IgG1 BP-HRP 套装

sc-542582
50 µg Ab; 20 µg BP
$354.00

I would appreciate information on the antigenic sequence of the product PINK1 Antibody (38CT20.8.5): sc-517353. This information would greatly assist my research on PINK1 cleavage. Please send me a e-mail. Thank you !

Asked by: Michael Li
Thank you for your question. The antibody sequence is proprietary but here is a link about the antibody .https://www.uniprot.org/uniprotkb/Q99MQ3/entry
Answered by: BlakeJ
Date published: 2023-11-30

Do you have rabbit anti-PINK1 antibody to detect mouse, human PINK1 protein? If you have would you please send a free sample.

Asked by: Mohasin
Thank you for your question. We do not currently offer any anti-PINK1 antibodies raised in rabbit.
Answered by: Technical Support
Date published: 2017-09-13
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Rated 5 out of 5 by from Works great for WBWorks well on neonatal mouse lungs at concentration of 30ug. Ab dilution will be 1:500 for overnight @ 4oC.
Date published: 2024-12-10
Rated 1 out of 5 by from No specific signals recognized in mouse tissueWe used PINK1 KO mice to verify this antibody and found that it actually could not detect specific signals instead of an approximate 60-KDa unspecific band.
Date published: 2023-12-19
Rated 5 out of 5 by from Good for Western BlotAntibody works well in human cell line A-431 and mouse cell line Sol8. -SCBT QC
Date published: 2023-09-14
Rated 3 out of 5 by from Works well for WB but not for IF or IHCCan be used at a dilution of 1:500 on neonatal mouse lung lysates
Date published: 2019-03-28
Rated 4 out of 5 by from Works well for WB but not for IFIt works on neonatal mouse lungs at a conc. of 30ug
Date published: 2019-03-11
Rated 3 out of 5 by from Not a great antibodyI used it in mice iWAT. I got bands, but i had a very strong background. Moreover i got two bands, one strong at 66KDa and one at 50KDa. So i don't know it if also recognizing the cleaved form or not. It is not specified in the datasheet.
Date published: 2019-03-01
Rated 5 out of 5 by from Good resultsGive me a robust results with this antibody. So I would recommend to my friends.
Date published: 2018-09-24
Rated 4 out of 5 by from Nice resultsAntibody worked well at dilution 1:100 on cryo sections of mouse urinary bladder.
Date published: 2018-05-07
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PINK1 抗体 (38CT20.8.5) is rated 3.8 out of 5 by 12.
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