Date published: 2025-9-6
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PGRMC1 Antibody (C-4) - Immunohistochemistry - Image 374748
PGRMC1 抗体 (C-4): sc-393015. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色, 显示肾小管细胞膜和细胞质染色.
PGRMC1 抗体 (C-4): sc-393015. 福尔马林固定, 石蜡包埋的人肾组织的免疫过氧化物酶染色, 显示肾小管细胞膜和细胞质染色.

PGRMC1 抗体 (C-4): sc-393015

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说明书
  • PGRMC1 抗体 C-4 是小鼠单克隆 IgM κ，PGRMC1抗体, 在14篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的PGRMC1的内部区域内的氨基酸61-92之间
  • 推荐用于 mouse, rat 和 human 来源的PGRMC1 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应，包括： 和 equine, canine, bovine and porcine
  • 可用于ChIP的TransCruz试剂(sc-393015 X, 200 µg/0.1 ml)
  • 关于如何获取PGRMC1 (C-4): sc-393015的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成PGRMC1 抗体 (C-4)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 PGRMC 抗体 包括 PGRMC2

PGRMC1抗体（C-4）是一种IgM κ小鼠单克隆PGRMC1抗体（也称为PGRMC1抗体），可通过WB、IP、IF、IHC(P)和ELISA检测到小鼠、大鼠和人类来源的PGRMC1蛋白。PGRMC1抗体（C-4）为非偶联的抗PGRMC1抗体。PGRMC1（孕激素受体膜组分1），也称为MPR，是一种由195个氨基酸组成的单次跨膜蛋白，定位于内质网和微粒体，并含有一个细胞色素b5血红素结合域。PGRMC1在多种组织中表达，在肾脏和肝脏中的表达量最高，作为孕激素的受体发挥作用。孕激素是一种参与胚胎发育并对女性正常发育至关重要的类固醇激素。编码PGRMC1的基因定位于人类X染色体，该染色体包含近1.53亿个碱基对和1000多个基因。X染色体与Y染色体结合负责性别决定，因为一条X染色体和一条Y染色体导致正常的男性发育，而两条X染色体则导致正常的女性发育。存在许多与性染色体数量和组合异常相关的疾病，其中一些包括特纳综合征、色盲、血友病和杜氏肌营养不良症。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

PGRMC1 抗体 (C-4) 参考文献:

  1. 人类膜孕酮受体基因：基因组结构和启动子分析。  |  Bernauer, S., et al. 2001. DNA Seq. 12: 13-25. PMID: 11697142
  2. 经典和非经典孕酮受体都在人类精子中表达。  |  Lösel, R., et al. 2005. Horm Metab Res. 37: 10-4. PMID: 15702432
  3. 人类有丝分裂纺锤体的磷酸蛋白组分析  |  Nousiainen, M., et al. 2006. Proc Natl Acad Sci U S A. 103: 5391-6. PMID: 16565220
  4. Dap1/PGRMC1 结合并调节细胞色素 P450 酶。  |  Hughes, AL., et al. 2007. Cell Metab. 5: 143-9. PMID: 17276356
  5. 孕酮受体膜成分 1--一种多功能蛋白质的多种任务。  |  Lösel, RM., et al. 2008. Steroids. 73: 929-34. PMID: 18249431
  6. 孕酮受体膜成分 1 及其伙伴丝氨酸 1 mRNA 结合蛋白在小鼠和人类子宫和胎盘组织中的表达。  |  Zhang, L., et al. 2008. Mol Cell Endocrinol. 287: 81-9. PMID: 18440126
  7. 卵巢早衰中黄体酮受体膜成分-1（PGRMC1）的表达, 结构和功能变化。  |  Mansouri, MR., et al. 2008. Hum Mol Genet. 17: 3776-83. PMID: 18782852
  8. PGRMC1 是多柔比星诱导的 MES-SA 子宫肉瘤化疗耐药性的诱因。  |  Lin, ST., et al. 2015. Cell Mol Life Sci. 72: 2395-409. PMID: 25596698
  9. 小鼠视网膜中孕酮受体膜组件 1 (PGRMC1) 的表达。  |  Shanmugam, AK., et al. 2016. Curr Eye Res. 41: 1105-1112. PMID: 26642738
  10. 黄体酮受体膜元件 1（PGRMC1）通过一种血红素依赖性机制结合并稳定细胞色素 P450。  |  McGuire, MR., et al. 2021. J Biol Chem. 297: 101316. PMID: 34678314
  11. E2 + 去甲孕酮通过 PGRMC1 促进 PI3K-AKT 通路，诱导乳腺癌细胞增殖。  |  Zhang, L., et al. 2022. Climacteric. 25: 467-475. PMID: 35137666
  12. 两种假定的类固醇膜受体的克隆和组织表达。  |  Gerdes, D., et al. 1998. Biol Chem. 379: 907-11. PMID: 9705155

订购信息

产品名称产品编号规格价格数量收藏夹

PGRMC1 抗体 (C-4)

sc-393015
200 µg/ml
$316.00

PGRMC1 (C-4) 中和勝肽

sc-393015 P
100 µg/0.5 ml
$68.00

PGRMC1 抗体 (C-4) X

sc-393015 X
200 µg/0.1 ml
$316.00

Hi. We have stained kidney samples with PGRMC1 antibody (sc-393015, Lot #2217) but the results is different from the brochure (gromerulus: negative, tubules: positive). Is the lot wrong? How can I go ahead with the staining?

Asked by: Knishi
Thank you for your question. Please contact our Technical Service Department for assistance in troubleshooting this antibody.
Answered by: Technical Support
Date published: 2019-06-16

What application is the blocking peptide sc-393015 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Good for WBI detected a band around 30 kDa in human and mouse cell lines.
Date published: 2021-04-21
Rated 5 out of 5 by from Excellent validated antibodyThe SCBT PGRMC1 antibody (Sc393015) detects the native PGRMC1 protein at ~22 kDa and several post translational modified forms at ~65 and ~110 kDa molecular weight equivalent bands in HEK293 total cell extracts (see the attached immunoblot picture). The higher molecular weight bands are possibly sumoylated forms (see Peluso et al. 2012, PMID:22719051) and trafficked to different cell organelles. The antibody is also equally good in immunofluorescence study (see the attached image). The antibody detected ER and nuclear localized PGRMC1 which has been previously reported by Human Protein Atlas PGRMC1 validated Sigma antibody HPA002877. Interestingly this SCBT antibody is comparable (Immunoblot and immunofluorescence) to the Protein atlas validated antibody Sigma, but the price is half of the Sigma antibody. So, I would highly recommend this as a cost effective and efficient antibody for your research. Go ahead and use this antibody for your research and make great discoveries. It’s an important protein.
Date published: 2018-03-02
Rated 5 out of 5 by from Western blot analysisWestern blot analysis PGRMC1 ,loading 40ug rat kidney lysates,positve band obtained at 27kda.
Date published: 2017-09-03
Rated 5 out of 5 by from clear bandWe use 1:500 dilution , the band is very clear and specific. Very satisfied! The antibody works in accordance with expectation.
Date published: 2017-08-18
Rated 5 out of 5 by from western blot detectionThis antibody was used for the western blot detection of mouse PGRMC1 in primary lymphocytes. These cells were grown in RPMI with 10% FBS. This antibody is very specific and no background was seen in whole cell lysates.
Date published: 2017-07-29
Rated 5 out of 5 by from The antibody is very niceThis antibody been used for analysis of PGRMC expressin in human liver cell line,it gave the strong target band at 28kda when use the condition 1:400 for incubated 1hour at room temperature..Since it is IgM antibody.I recommend use the anti mouse IgM secondary.
Date published: 2017-07-08
Rated 5 out of 5 by from nice stainingIHC of paraffin-embedded human tissue showed nice staining with no background,dilution 1:300 shows strong signal.
Date published: 2017-05-13
Rated 5 out of 5 by from ImmunofluorescenceNice immunofluorescence staining in human adrenal cells.
Date published: 2017-02-14
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PGRMC1 抗体 (C-4) is rated 5.0 out of 5 by 13.
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