PDGF-D Antibody (E-3): sc-137030

PDGF-D Antibody (E-3) is a mouse monoclonal IgG2b antibody that detects PDGF-D in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PDGF-D plays a crucial role in various biological processes, particularly in the regulation of cell growth and survival, making PDGF-D essential for the development and maintenance of connective tissues. PDGF-D is secreted as a disulphide-linked homodimer known as PDGF-DD, which is activated through limited proteolysis to specifically bind to the PDGFR-β receptor, thereby initiating signaling pathways that influence cellular functions. PDGF-D expression is notably observed in fibroblastic adventitial cells, cultured endothelial cells, and various tumor cell lines, highlighting PDGF-D significance in both normal physiology and pathological conditions. Anti-PDGF-D antibody (E-3) is an invaluable tool for researchers aiming to explore the intricate roles of PDGF-D in development, tissue repair, and cancer biology, providing insights into its interactions and regulatory mechanisms within the cellular environment.

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PDGF-D Antibody (E-3) References:

1. Platelet-derived growth factor-D expression in developing and mature human kidneys.  |  Changsirikulchai, S., et al. 2002. Kidney Int. 62: 2043-54. PMID: 12427128
2. Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.  |  Cadamuro, M., et al. 2013. Hepatology. 58: 1042-53. PMID: 23505219
3. Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts.  |  Zhao, T., et al. 2013. Am J Physiol Heart Circ Physiol. 304: H1719-26. PMID: 23585135
4. Over-expression of platelet-derived growth factor-D promotes tumor growth and invasion in endometrial cancer.  |  Wang, Y., et al. 2014. Int J Mol Sci. 15: 4780-94. PMID: 24646915
5. Platelet-derived growth factor-D modulates extracellular matrix homeostasis and remodeling through TIMP-1 induction and attenuation of MMP-2 and MMP-9 gelatinase activities.  |  Borkham-Kamphorst, E., et al. 2015. Biochem Biophys Res Commun. 457: 307-13. PMID: 25576870
6. Dynamic regulation of platelet-derived growth factor D (PDGF-D) activity and extracellular spatial distribution by matriptase-mediated proteolysis.  |  Huang, W. and Kim, HR. 2015. J Biol Chem. 290: 9162-70. PMID: 25678707
7. Platelet-derived growth factor-D expression mediates the effect of differentiated degree on prognosis in epithelial ovarian cancer.  |  Yang, C., et al. 2019. J Cell Biochem. 120: 6920-6925. PMID: 30652340
8. PDGF-D activation by macrophage-derived uPA promotes AngII-induced cardiac remodeling in obese mice.  |  Cheng, YW., et al. 2021. J Exp Med. 218: PMID: 34236404
9. Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression.  |  Parry, CM., et al. 2023. Pediatr Res. 93: 97-101. PMID: 35568735
10. PDGF-D-induced immunoproteasome activation and cell-cell interactions.  |  Zhang, J., et al. 2023. Comput Struct Biotechnol J. 21: 2405-2418. PMID: 37066124

The preferred PDGF-D antibody is PDGF-D Antibody (E-7): sc-137029.