pan cathepsin Antibody (H-1): sc-376803

pan cathepsin Antibody (H-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects pan cathepsin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). pan cathepsin (H-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The cathepsin family consists of a diverse array of proteolytic enzymes, with cathepsins playing crucial roles in cellular metabolism, including peptide biosynthesis and protein degradation. Notably, cathepsin L, a member of the cysteine protease class, is particularly significant due to its involvement in various physiological processes, such as antigen processing and regulation of apoptosis. Proper functioning of cathepsin L is essential for maintaining cellular homeostasis, and dysregulation of cathepsin L activity has been implicated in several diseases, including cancer and neurodegenerative disorders. Understanding cathepsin L interactions with other proteins, such as cathepsin H, can provide insights into functional mechanisms and potential therapeutic targets.

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pan cathepsin Antibody (H-1) References:

1. Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.  |  Shi, GP., et al. 1992. J Biol Chem. 267: 7258-62. PMID: 1373132
2. Molecular organization of the human cathepsin D gene.  |  Redecker, B., et al. 1991. DNA Cell Biol. 10: 423-31. PMID: 2069717
3. Molecular probes for selective detection of cysteine cathepsins.  |  Schleyer, KA. and Cui, L. 2021. Org Biomol Chem. 19: 6182-6205. PMID: 34288999
4. Molecular cloning and sequencing of cDNA for rat cathepsin L.  |  Ishidoh, K., et al. 1987. FEBS Lett. 223: 69-73. PMID: 3666143
5. Molecular cloning and sequencing of cDNA for rat cathepsin H. Homology in pro-peptide regions of cysteine proteinases.  |  Ishidoh, K., et al. 1987. FEBS Lett. 226: 33-7. PMID: 3691815
6. Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein.  |  Anderson, A. and Tansey, MG. 2023. bioRxiv.. PMID: 37503267
7. Targeting cellular cathepsins inhibits hepatitis E virus entry.  |  Klöhn, M., et al. 2024. Hepatology. 80: 1239-1251. PMID: 38728662
8. Isolation and sequencing of two cDNA clones encoding rat spleen cathepsin E and analysis of the activation of purified procathepsin E.  |  Okamoto, K., et al. 1995. Arch Biochem Biophys. 322: 103-11. PMID: 7574663
9. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2.  |  Shi, GP., et al. 1995. FEBS Lett. 357: 129-34. PMID: 7805878
10. Cathepsin B, a cysteine protease implicated in metastatic progression, is also expressed during regression of the rat prostate and mammary glands.  |  Guenette, RS., et al. 1994. Eur J Biochem. 226: 311-21. PMID: 8001549
11. Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene.  |  Heusel, JW., et al. 1993. Blood. 81: 1614-23. PMID: 8453108
12. Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development.  |  Rantakokko, J., et al. 1996. FEBS Lett. 393: 307-13. PMID: 8814310

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-pan cathepsin Antibody (H-1) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-pan cathepsin Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

pan cathepsin Antibody (H-1) Specifications

Alternate Product Name: cathepsin

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 107-145

Epitope Target: cathepsin

Epitope Species: human

Product Reactivity/Detection: a broad range of cathepsin proteins

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for pan cathepsin Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin