p-PDGF Receptor beta/PDGFRB Antibody (H-8): sc-373805

p-PDGFR-β Antibody (H-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects phosphorylated PDGF receptor beta (p-PDGFR-β) at Tyr 1009 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p-PDGFR-β (H-8) antibody is offered in both non-conjugated and various conjugated formats, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The platelet-derived growth factor (PDGF) receptor beta plays a crucial role in cellular processes such as proliferation, migration, and survival, particularly in mesenchymal and glial cells. PDGF consists of two chains, A and B, which form distinct isoforms that bind to two receptor types, α and β, leading to receptor dimerization and activation of intrinsic protein tyrosine kinase activity. Upon ligand binding, PDGFR-β undergoes autophosphorylation at key tyrosine residues, including Tyr 857 and Tyr 751, which are essential for downstream signaling pathways. Notably, the phosphorylation of Tyr 751 is critical for the recruitment of phosphatidylinositol-3 kinase, a key player in mediating various cellular responses. anti-p-PDGFR-β antibody (H-8) specifically recognizes the phosphorylated receptor, making this antibody an invaluable tool for studying PDGF signaling pathways and their implications in various physiological and pathological conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-PDGF Receptor beta/PDGFRB Antibody (H-8) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p-PDGF Receptor beta/PDGFRB Antibody (H-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-PDGF Receptor beta/PDGFRB Antibody (H-8) Specifications

Alternate Product Name: PDGFRB

Product Clone Name: H-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Tyr 1009

Epitope Target: PDGFR-β

Epitope Species: human

Product Reactivity/Detection: Tyr 1009 phosphorylated PDGFR-β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p-PDGF Receptor beta/PDGFRB Antibody (H-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred PDGF Receptor beta/PDGFRB antibody is PDGF Receptor beta/PDGFRB Antibody (D-6): sc-374573.