p-EGFR Antibody (6D372): sc-71776

p-EGFR Antibody (6D372) is a mouse monoclonal IgG1 antibody that detects epidermal growth factor receptor (EGFR) in mouse, rat, human, and canine samples through western blotting (WB). anti-p-EGFR antibody (6D372) is raised against an EGFR phosphopeptide of human origin and recognizes phosphorylated forms of EGFR, which is crucial for understanding its role in cell signaling and growth regulation. EGFR is primarily located on the cell surface, where EGFR functions as a receptor for epidermal growth factor and other ligands, initiating a cascade of intracellular signaling pathways that promote cell proliferation, survival, and differentiation. Proper localization of EGFR is vital, as activation at the cell membrane leads to autophosphorylation at specific tyrosine residues, which in turn facilitates recruitment of downstream signaling proteins, such as GRB2, to propagate the signal. Dysregulation of EGFR signaling, including constitutive activation or overexpression, is a hallmark of many cancers, where EGFR contributes to uncontrolled growth, metastasis, and resistance to therapies. p-EGFR (6D372) monoclonal antibody provides a tool to gain insights into the phosphorylation status of EGFR and functional implications in cellular processes, thereby advancing the understanding of EGFR′s role in health and disease.

The preferred EGFR antibody is EGFR Antibody (528): sc-120.