p-Androgen Receptor Antibody (156C135.2): sc-52894

p-AR Antibody (156C135.2) is a mouse monoclonal IgG antibody that detects the p-AR protein of mouse, rat, human, porcine, and canine origin by western blotting (WB). p-AR Antibody (156C135.2) is available as the non-conjugated anti-p-AR antibody, providing researchers with a reliable tool for studying androgen receptor dynamics. The androgen receptor (AR) plays a crucial role in mediating the effects of androgens, which are vital for the development and maintenance of male reproductive physiology and phenotype. Located primarily in the cytoplasm and nucleus of target cells, AR translocates to the nucleus upon binding to testosterone (T) and dihydrotestosterone (DHT), where AR regulates gene expression. This translocation is essential for AR function, as AR influences various biological processes, including cell growth and differentiation. Notably, the binding kinetics of T and DHT differ significantly, with testosterone exhibiting a threefold faster association and dissociation rate compared to dihydrotestosterone. This difference in kinetics contributes to the distinct physiological effects observed with each androgen. Furthermore, androgen binding enhances AR stability, increasing AR functional lifespan within the cell. The phosphorylation of AR by Akt at specific serine residues, such as Serines 210 and 790, further modulates AR activity, highlighting the importance of post-translational modifications in regulating receptor function. The synthetic androgen R1881 has also been shown to elevate phosphorylation at Serines 308 and 650 in vitro, underscoring the complex regulatory mechanisms governing AR signaling.

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p-Androgen Receptor Antibody (156C135.2) References:

1. Androgen receptor corepressors: an overview.  |  Wang, L., et al. 2005. Prostate. 63: 117-30. PMID: 15486994
2. Androgen receptor and prostate cancer.  |  Richter, E., et al. 2007. Prostate Cancer Prostatic Dis. 10: 114-8. PMID: 17297502
3. Androgen receptor-mediated gene repression.  |  Grosse, A., et al. 2012. Mol Cell Endocrinol. 352: 46-56. PMID: 21784131
4. Androgen receptor antagonists: a patent review (2008-2011).  |  Mohler, ML., et al. 2012. Expert Opin Ther Pat. 22: 541-65. PMID: 22583332
5. Androgen receptor signaling pathways as a target for breast cancer treatment.  |  Pietri, E., et al. 2016. Endocr Relat Cancer. 23: R485-98. PMID: 27528625
6. Androgen receptor phosphorylated at Ser815: The expression and function in the prostate and tumor-derived cells.  |  Yokobori, K., et al. 2021. Biochem Pharmacol. 194: 114794. PMID: 34715066
7. Cell-specific functions of androgen receptor in skeletal muscles.  |  Sakai, H. and Imai, Y. 2024. Endocr J. 71: 437-445. PMID: 38281756
8. Androgen receptor and mechanism of androgen action.  |  Jänne, OA., et al. 1993. Ann Med. 25: 83-9. PMID: 8435194
9. Androgen receptor phosphorylation.  |  Blok, LJ., et al. 1996. Endocr Res. 22: 197-219. PMID: 8875135
10. The androgen receptor: a mediator of diverse responses.  |  Keller, ET., et al. 1996. Front Biosci. 1: d59-71. PMID: 9159212

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Androgen Receptor Antibody (156C135.2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Androgen Receptor Antibody (156C135.2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Androgen Receptor Antibody (156C135.2) Specifications

Alternate Product Name: Androgen Receptor

Product Clone Name: 156C135.2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids: Ser 213/210

Epitope Target: p-AR

Epitope Species: human

Product Reactivity/Detection: Ser 213 and Ser 210 phosphorylated AR

Species Reactivity/Detection: mouse, rat, human, porcine, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p-Androgen Receptor Antibody (156C135.2): N/A

The preferred Androgen Receptor antibody is Androgen Receptor Antibody (441): sc-7305.