Date published: 2025-9-9

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ODC 抗体 (G-10): sc-390366

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说明书
  • ODC抗体(G-10)是小鼠单克隆IgG1 κ, 在6篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的ODC的内部区域内的氨基酸351-385之间
  • 推荐用于 mouse, rat 和 human 来源的ODC WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 ODC 抗体 (G-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与ODC 抗体 (G-10) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

鸟氨酸脱羧酶(ODC)是一种酶,通过将鸟氨酸转化为腐胺和二氧化碳,在多胺生物合成中执行第一步。ODC在多种生物过程中起着重要作用,包括细胞生长、分化、转化和凋亡。Sp1、c-Myc和c-Fos基因作为ODC启动子的反式激活因子,ZBP-89作为反式阻遏因子。ODC基因的过表达在细胞增殖和癌症的发生发展中起着重要作用。ODC启动子中高水平的蛋白结合与该基因组成型表达升高有关。多胺水平升高通过增强抗酶mRNA的翻译导致ODC活性的下调,导致抗酶随后与ODC单体结合,以靶向ODC,使其被26S蛋白体蛋白水解。DFMO(DL-a-二氟甲基鸟氨酸)是ODC的不可逆抑制剂,可诱导细胞凋亡并抑制细胞生长。ODC也与血管生成有关,ODC过表达细胞表现出对XVIII型胶原和内皮抑素的抑制表达,表明ODC的过表达通过抑制内皮抑素表达促进内皮细胞增殖。ODC基因位于人类染色体2p25。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ODC 抗体 (G-10) 参考文献:

  1. 卵巢肿瘤细胞分泌可溶性补体抑制因子H和因子H样蛋白(FHL-1)。  |  Junnikkala, S., et al. 2002. Br J Cancer. 87: 1119-27. PMID: 12402151
  2. 人类补体因子H可调节C1q介导的凋亡细胞吞噬作用。  |  Kang, YH., et al. 2012. Immunobiology. 217: 455-64. PMID: 22088229
  3. 因子H结合蛋白的克隆、表达和纯化及其与因子H的相互作用。  |  Yarian, F., et al. 2016. Iran J Microbiol. 8: 29-35. PMID: 27092222
  4. 尿蛋白结合素和补体因子H的相互作用增强C3b的失活。  |  Liu, M., et al. 2016. J Cell Mol Med. 20: 1821-8. PMID: 27113631
  5. 血浆中补体因子H的缺失会增加内皮细胞的迁移。  |  Liu, J. and Hoh, J. 2017. J Cancer. 8: 2184-2190. PMID: 28819420
  6. 血浆补体因子H的增加与老年抑郁症有关。  |  Shin, C., et al. 2019. Int Psychogeriatr. 31: 101-108. PMID: 29798743
  7. C57BL6小鼠体内补体因子H的缺失会降低其身体机能。  |  Seldeen, KL., et al. 2020. Immunobiology. 225: 152003. PMID: 32962822
  8. 局部补体因子H保护肾内皮细胞结构和功能。  |  Mahajan, S., et al. 2021. Kidney Int. 100: 824-836. PMID: 34139209
  9. 补体因子H在妊娠糖尿病和妊娠中的作用。  |  Li, J., et al. 2021. BMC Pregnancy Childbirth. 21: 562. PMID: 34404360
  10. 用抗因子H的抗体鉴定淋巴细胞膜上因子H(β1H-球蛋白)受体的特征。  |  Lambris, JD. and Ross, GD. 1982. J Exp Med. 155: 1400-11. PMID: 6461713

订购信息

产品名称产品编号规格价格数量收藏夹

ODC 抗体 (G-10)

sc-390366
200 µg/ml
$316.00

ODC (G-10): m-IgG Fc BP-HRP 套装

sc-538082
200 µg Ab; 10 µg BP
$354.00

ODC (G-10): m-IgGκ BP-HRP 套装

sc-535617
200 µg Ab; 40 µg BP
$354.00

ODC (G-10): m-IgG1 BP-HRP 套装

sc-545513
200 µg Ab; 20 µg BP
$354.00

ODC (G-10) 中和勝肽

sc-390366 P
100 µg/0.5 ml
$68.00

does it really applied for mice? thx!

Asked by: Anonymous
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-23

What application is the blocking peptide sc-390366 P appropriate for?

Asked by: jenniferc
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from nice dark western blot bandWe used this antibody for ODC expression detection with western blot. We got a nice dark band at the correct molecular weight
Date published: 2017-02-01
Rated 5 out of 5 by from Superb immunoperoxidase cytoplasmic stainingSuperb immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human small intestine tissue. -SCBT QC
Date published: 2015-05-15
Rated 5 out of 5 by from Nice Western Blot data of ODC expression in nonNice Western Blot data of ODC expression in non-transfected and human ODC transfected 293T whole cell lysates. -SCBT QC
Date published: 2013-07-08
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ODC 抗体 (G-10) is rated 5.0 out of 5 by 3.
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