Date published: 2025-9-7

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NPY1-R 抗体 (E-4): sc-393192

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说明书
  • NPY1-R 抗体 E-4 是小鼠单克隆 IgG2a κ,NPY1-R抗体, 在7篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列181-271位于human物种的NPY1-R的内部区域内
  • NPY1-R 抗体 (E-4) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 NPY1-R
  • 抗NPY1-R抗体(E-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取NPY1-R (E-4): sc-393192免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是NPY1-R Antibody (E-4) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与NPY1-R Antibody (E-4) 打包提供(请参阅下面的订购信息)。

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関連項目

NPY1-R抗体(E-4)是一种IgG2a κ小鼠单克隆NPY1-R抗体(也称为NPY1-R抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的NPY1-R蛋白。NPY1-R抗体(E-4)既有非偶联的抗NPY1-R抗体形式,也有多种偶联形式的抗NPY1-R抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。NPY1R基因位于人类染色体4q32上,编码384个氨基酸的蛋白质NPY1-R(也称为神经肽Y受体Y1)。NPY1-R是G蛋白偶联受体超家族的成员,与其他成员一样,具有七个假定的跨膜结构域。然而,与其他G蛋白偶联受体基因的连续结构不同,NPY1-R基因由三个外显子组成。NPY1-R在脾、小肠、肾、睾丸、胎盘、主动脉平滑肌以及整个中枢神经系统的突触后膜中表达。NPY1-R与神经肽Y、非磷酸化肽YY(PYY)以及特别是磷酸化PYY强烈结合。根据细胞类型,NPY1-R与不同的G蛋白偶联,这些G蛋白充当第二信使。NPY1-R的激活对于释放疼痛神经递质P物质和引发神经源性炎症是必要且充分的。NPY1-R通过与NPY的相互作用刺激摄食行为。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NPY1-R 抗体 (E-4) 参考文献:

  1. 大鼠中枢神经系统神经肽 Y1 受体的免疫组化定位  |  Migita, K., et al. 2001. Brain Res. 889: 23-37. PMID: 11166683
  2. 典型的 Y1 受体调节摄食行为:强效选择性 Y1 拮抗剂 J-115814 的作用。  |  Kanatani, A., et al. 2001. Mol Pharmacol. 59: 501-5. PMID: 11179445
  3. 缺乏神经肽 Y 受体的小鼠抗痛觉能力和血浆外渗能力下降  |  Naveilhan, P., et al. 2001. Nature. 409: 513-7. PMID: 11206547
  4. 具有强大生物活性的猪肠 Ser(13)-phosphorylated PYY。  |  Chen, Z., et al. 2001. FEBS Lett. 492: 119-22. PMID: 11248248
  5. 人Y1型神经肽Y/肽YY受体的克隆和功能表达。  |  Larhammar, D., et al. 1992. J Biol Chem. 267: 10935-8. PMID: 1317848
  6. 克隆的人类神经肽 Y 受体与两种不同的第二信使系统耦合。  |  Herzog, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 5794-8. PMID: 1321422
  7. NPY受体在人类癌症中的研究:当前知识综述。  |  Körner, M. and Reubi, JC. 2007. Peptides. 28: 419-25. PMID: 17223228
  8. NPY和脑单胺在癌症厌食症发病机理中的作用。  |  Laviano, A., et al. 2008. Nutrition. 24: 802-5. PMID: 18662859
  9. 基于NPY的单克隆抗体在乳腺癌诊断和治疗中的战略意义。  |  Desai, D. and Shende, P. 2020. Curr Protein Pept Sci. 21: 1097-1102. PMID: 32951575
  10. NPY和癫痫基因治疗:如何、何时……以及Y。  |  Cattaneo, S., et al. 2020. Front Mol Neurosci. 13: 608001. PMID: 33551745
  11. 白术素通过调节NPY,通过下丘脑Sirt1/AMPK轴诱导的细胞自噬,缓解癌症厌食-恶病质综合征。  |  Yu, B., et al. 2022. Biochem Biophys Res Commun. 625: 154-160. PMID: 35963161
  12. 人类神经肽 Y1 受体基因的基因组结构, 定位和等位基因差异。  |  Herzog, H., et al. 1993. J Biol Chem. 268: 6703-7. PMID: 8095935

订购信息

产品名称产品编号规格价格数量收藏夹

NPY1-R 抗体 (E-4)

sc-393192
200 µg/ml
$316.00

NPY1-R (E-4): m-IgGκ BP-HRP 套装

sc-523846
200 µg Ab, 40 µg BP
$354.00

NPY1-R (E-4): m-IgG2a BP-HRP 套装

sc-546170
200 µg Ab; 10 µg BP
$354.00

NPY1-R 抗体 (E-4) AC

sc-393192 AC
500 µg/ml, 25% agarose
$416.00

NPY1-R 抗体 (E-4) HRP

sc-393192 HRP
200 µg/ml
$316.00

NPY1-R 抗体 (E-4) FITC

sc-393192 FITC
200 µg/ml
$330.00

NPY1-R 抗体 (E-4) PE

sc-393192 PE
200 µg/ml
$343.00

NPY1-R 抗体 (E-4) Alexa Fluor® 488

sc-393192 AF488
200 µg/ml
$357.00

NPY1-R 抗体 (E-4) Alexa Fluor® 546

sc-393192 AF546
200 µg/ml
$357.00

NPY1-R 抗体 (E-4) Alexa Fluor® 594

sc-393192 AF594
200 µg/ml
$357.00

NPY1-R 抗体 (E-4) Alexa Fluor® 647

sc-393192 AF647
200 µg/ml
$357.00

NPY1-R 抗体 (E-4) Alexa Fluor® 680

sc-393192 AF680
200 µg/ml
$357.00

NPY1-R 抗体 (E-4) Alexa Fluor® 790

sc-393192 AF790
200 µg/ml
$357.00

Is this antibody conjugated with AF790 suitable for detecting Mouse NPY Y1R by flow cytometry? If yes, do we need to do cell surface staining or intracellular staining?

Asked by: Dinisha
Thank you for your question. NPY1-R (E-4) antibody is recommended for mouse, rat and human samples for WB, IP, IF, ELISA. We have not validated the antibody for flow cytometry.
Answered by: BlakeJ
Date published: 2024-12-12

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-393192: NPY1-R (E-4) mouse monoclonal antibody will work?

Asked by: Cweed
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from great band in WBi got this antibody from santa cruz manager, it worked very well, clear band showed.
Date published: 2017-10-25
Rated 5 out of 5 by from very goodWB or staining, very good antibody, used on multiple cell lines and tissue types.
Date published: 2017-03-05
Rated 5 out of 5 by from outstanding antibodyvery outstanding antibody for Western blot. Strong signal obtained at dilution 1:500
Date published: 2017-02-26
Rated 5 out of 5 by from Specific and single bandGet clear bands at correct position for mouse brain tissue detect, strong bands seen in WB.
Date published: 2017-02-12
Rated 5 out of 5 by from works for westernGreat antibody for Western blot, strong band detected in mouse brain.
Date published: 2017-02-11
Rated 5 out of 5 by from Produced positive Western blot data of NPY1Produced positive Western blot data of NPY1-R expression in mouse brain and human hippocampus tissue extracts. -SCBT QC
Date published: 2013-06-12
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NPY1-R 抗体 (E-4) is rated 5.0 out of 5 by 6.
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