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NGFR p75 抗体 (G-5): sc-25283

5.0(1)
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说明书
  • NGFR p75抗体(G-5)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 推荐用于 human 来源的NGFR p75 WB, IP, IF 和 ELISA检测
  • 看 NGFR p75 (B-1): sc-271708,可查看有标记的 NGFR p75 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是NGFR p75 Antibody (G-5) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与NGFR p75 Antibody (G-5) 打包提供(请参阅下面的订购信息)。
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    関連項目

    Trk癌基因编码一种跨膜蛋白酪氨酸激酶,即gp140Trk,其在体内的表达仅限于来源于神经嵴的感觉脊髓和颅神经节神经元。神经生长因子(NGF)在神经细胞系和胚胎背根神经节中刺激Trk A的酪氨酸磷酸化。NGF对Trk的酪氨酸磷酸化作用迅速且特异,并且仅需极微量的因子即可发生,这表明该反应是由生理量的NGF介导的,暗示Trk A参与了NGF的主要信号转导机制。Trk A受体复合物的另一个组成部分NGFR p75与神经营养因子的亲和力较低,但对于有效的信号传导却是必需的。NGFR p75加速了Trk A的激活,并可能招募下游效应分子到配体结合的复合物中。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    NGFR p75 抗体 (G-5) 参考文献:

    1. 通过p75神经营养因子受体的神经营养因子信号传导。  |  Roux, PP. and Barker, PA. 2002. Prog Neurobiol. 67: 203-33. PMID: 12169297
    2. p75神经营养因子受体在神经系统中的多重作用。  |  Chen, Y., et al. 2009. J Int Med Res. 37: 281-8. PMID: 19383220
    3. Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.  |  Meeker, R. and Williams, K. 2014. J Neuroimmune Pharmacol. 9: 615-28. PMID: 25239528
    4. p75NTR在维持脑部止血中的作用以及对p75NTR靶向治疗的影响。  |  Gao, C., et al. 2017. Curr Alzheimer Res. 14: 554-561. PMID: 28110636
    5. Death domain of p75 neurotrophin receptor: a structural perspective on an intracellular signalling hub.  |  Yuan, W., et al. 2019. Biol Rev Camb Philos Soc. 94: 1282-1293. PMID: 30762293
    6. p75神经营养因子受体抑制剂LM11A-31可减轻急性中风损伤并调节星形胶质细胞前NGF。  |  Nasoohi, S., et al. 2023. Exp Neurol. 359: 114161. PMID: 35787888
    7. The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice.  |  Chehrazi, P., et al. 2023. Biol Psychiatry. 94: 310-321. PMID: 37120061
    8. p75神经营养因子受体(p75NTR)在癫痫中的功能和分子作用。  |  Turkistani, A., et al. 2024. J Cent Nerv Syst Dis. 16: 11795735241247810. PMID: 38655152
    9. 大鼠发育、生长和生育过程中p75NTR神经营养因子受体功能的冗余性。  |  Meek, S., et al. 2024. Transgenic Res. 33: 255-266. PMID: 38981975
    10. The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis.  |  Peng, L., et al. 2024. CNS Neurosci Ther. 30: e14875. PMID: 39072998

    订购信息

    产品名称产品编号规格价格数量收藏夹

    NGFR p75 抗体 (G-5)

    sc-25283
    200 µg/ml
    $322.00

    NGFR p75 (G-5): m-IgG Fc BP-HRP 套装

    sc-536700
    200 µg Ab; 10 µg BP
    $361.00

    NGFR p75 (G-5): m-IgGκ BP-HRP 套装

    sc-533860
    200 µg Ab; 40 µg BP
    $361.00

    NGFR p75 (G-5): m-IgG2a BP-HRP 套装

    sc-547850
    200 µg Ab; 10 µg BP
    $361.00

    What is the recommended secondary reagent to be used with sc-25283: NGFR p75 (G-5) mouse monoclonal primary?

    Asked by: Dr Ninau Qelp
    We recommend using one our exclusive Mouse IgG Binding Proteins as a secondary detection reagent. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
    Answered by: Technical Support
    Date published: 2017-04-12
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    Rated 5 out of 5 by NZ from Produced nice Western blot data of NGFR p75Produced nice Western blot data of NGFR p75 expression in SK-N-MC whole cell lysate. -SCBT QC
    Date published: 2014-10-21
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    NGFR p75 抗体 (G-5) is rated 5.0 out of 5 by 1.
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