NGF Antibody (NGF30): sc-32300
- NGF Antibody (NGF30) is a rat monoclonal IgG1, cited in 12 publications, provided at 200 µg/ml
- raised against NGF of mouse origin
- recommended for detection of native and denatured NGF of mouse and rat origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NGF Antibody (NGF30). This work is in progress.
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NGF Antibody (NGF30) is a rat monoclonal IgG1 antibody raised against nerve growth factor (NGF) of mouse origin, capable of detecting native and denatured NGF from mouse and rat by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). NGF, also known as beta-nerve growth factor, is a critical neurotrophin involved in the regulation of neuronal survival, development, and function. NGF promotes the survival and differentiation of sympathetic and sensory neurons during development and plays a key role in neuroplasticity and repair processes within the adult nervous system. NGF exerts its effects primarily through binding to the high-affinity receptor TrkA (tropomyosin receptor kinase A) but can also interact with the low-affinity receptor p75NTR, influencing a variety of intracellular signaling pathways. Dysregulation of NGF expression or signaling has been implicated in neurodegenerative diseases such as Alzheimer′s disease and peripheral neuropathies, making NGF a significant target for research. Anti-NGF antibody (NGF30) is an essential tool for scientists investigating NGF′s role in neuronal survival, growth, and potential therapeutic applications. NGF monoclonal antibody (NGF30) aids in advancing our understanding of neurotrophin-mediated signaling pathways and their implications in neurological disorders.
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NGF Antibody (NGF30) References:
- NGF in CNS: experimental data and clinical implications. | Ebendal, T. 1989. Prog Growth Factor Res. 1: 143-59. PMID: 2562358
- The NGF Metabolic Pathway in the CNS and its Dysregulation in Down Syndrome and Alzheimer's Disease. | Iulita, MF. and Cuello, AC. 2016. Curr Alzheimer Res. 13: 53-67. PMID: 26391047
- NGF/TrkA Signaling as a Therapeutic Target for Pain. | Hirose, M., et al. 2016. Pain Pract. 16: 175-82. PMID: 26452158
- NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems. | Bracci-Laudiero, L. and De Stefano, ME. 2016. Curr Top Behav Neurosci. 29: 125-152. PMID: 26695167
- NGF-dependent neurons and neurobiology of emotions and feelings: Lessons from congenital insensitivity to pain with anhidrosis. | Indo, Y. 2018. Neurosci Biobehav Rev. 87: 1-16. PMID: 29407522
- Role of NGF on sperm traits: A review. | Castellini, C., et al. 2020. Theriogenology. 150: 210-214. PMID: 32000995
- Nerve Growth Factor (NGF) and Animal Reproduction. | Maranesi, M., et al. 2021. Adv Exp Med Biol. 1331: 277-287. PMID: 34453306
- NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression. | Wang, L., et al. 2021. Front Oncol. 11: 688794. PMID: 34722240
- NGF and the treatment of Alzheimer's disease. | Olson, L. 1993. Exp Neurol. 124: 5-15. PMID: 8282080
- NGF as a mediator of inflammatory pain. | McMahon, SB. 1996. Philos Trans R Soc Lond B Biol Sci. 351: 431-40. PMID: 8730782
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NGF Antibody (NGF30) | sc-32300 | 200 µg/ml | $322.00 |