Date published: 2026-10-19

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NFATc4 抗体 (F-3): sc-271091

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说明书
  • NFATc4抗体(F-3)是小鼠单克隆IgG2b κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫human物种的NFATc4的氨基酸125-198
  • 推荐用于 human 来源的NFATc4 WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-271091 X, 200 µg/0.1 ml)
  • 看 NFATc4 (B-2): sc-271597,可查看有标记的 NFATc4 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP是NFATc4 Antibody (F-3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与NFATc4 Antibody (F-3) 打包提供(请参阅下面的订购信息)。
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関連項目

NFATc4(活化T细胞核因子,细胞质,钙调神经磷酸酶依赖性4)是活化T细胞DNA结合转录复合物的核因子成员,影响细胞因子基因表达、心肌肥大和脂肪细胞分化。该复合物至少由两个组分组成:一个在T细胞受体(TCR)刺激下易位到核的细胞质组分和一个诱导性核组分。该家族的其他成员参与该复合物的形成。 NFATc4在T细胞中细胞因子基因的诱导表达中发挥作用,包括诱导IL-2和IL-4。 p38 MAP激酶磷酸化NFATc4的NFAT同源结构域中的多个残基。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NFATc4 抗体 (F-3) 参考文献:

  1. 在 miR-133a 介导的心肌细胞肥大抑制过程中,NFATc4 受到负调控。  |  Li, Q., et al. 2010. Am J Physiol Heart Circ Physiol. 298: H1340-7. PMID: 20173049
  2. 在 ET-1 诱导的心肌细胞肥大中,NFATc4 和 myocardin 协同上调 LTCC α1C 的表达。  |  Li, M., et al. 2016. Life Sci. 155: 11-20. PMID: 27155398
  3. Nfatc4缺陷通过抑制Tnf介导的小鼠耳蜗毛细胞凋亡来减轻耳毒性。  |  Zhang, Y., et al. 2019. Front Immunol. 10: 1660. PMID: 31379853
  4. NFATC4 促进卵巢癌的静止期和化疗耐药性。  |  Cole, AJ., et al. 2020. JCI Insight. 5: PMID: 32182216
  5. 靶向NFATc4可减轻小鼠的非酒精性脂肪性肝炎。  |  Du, M., et al. 2020. J Hepatol. 73: 1333-1346. PMID: 32717288
  6. CAMTA1-PPP3CA-NFATc4多蛋白复合物介导结直肠癌对奥沙利铂的耐药性。  |  Pan, R., et al. 2022. Cell Death Discov. 8: 129. PMID: 35332122
  7. NFATc4在肿瘤发生和癌症预后中的最新知识。  |  Zhong, QH., et al. 2022. Cancer Cell Int. 22: 212. PMID: 35698138
  8. NFATC4基因在人类皮肤鳞状细胞癌中的作用。  |  Li, F., et al. 2023. Indian J Dermatol. 68: 156-160. PMID: 37275813
  9. 甲基转移酶Mettl1通过调节SRSF9介导的NFATc4剪接来驱动心脏肥大。  |  Yu, S., et al. 2024. Adv Sci (Weinh). 11: e2308769. PMID: 38810124
  10. AKAP6通过控制BDNF介导的神经保护作用来控制NFATc4的活性。  |  Mackiewicz, J., et al. 2024. Mol Brain. 17: 85. PMID: 39578909

订购信息

产品名称产品编号规格价格数量收藏夹

NFATc4 抗体 (F-3)

sc-271091
200 µg/ml
$322.00

NFATc4 (F-3): m-IgG2b BP-HRP 套装

sc-548535
200 µg Ab; 10 µg BP
$361.00

NFATc4 抗体 (F-3) X

sc-271091 X
200 µg/0.1 ml
$322.00

Is this antibody suited to detect NFAT in cytoplasm and in the nuclei of cells?

Asked by: Sebastian M
Thank you for your question. NFATc4 Antibody (F-3): sc-271091 is suitable for the detection of intracellular NFATc4. Depending on the sample, antigen demasking may be necessary. You can find our recommended protocol for immunofluorescence, IHC and different antigen demasking methods by following this link: https://www.scbt.com/scbt/de/resources/protocols/immunofluorescence-cell-staining
Answered by: SCBT Heidelberg Support
Date published: 2018-12-22

What is the recommended fixation method for immunofluorescence staining with NFATc4 (F-3): sc-271091 monoclonal antibody?

Asked by: jerojero
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by CJ from Observed robust band in NFATc4 transfectedObserved robust band in NFATc4 transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-02-28
Rated 5 out of 5 by QZ from Excellent immunofluorescence cytoplasmicExcellent immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-01-02
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NFATc4 抗体 (F-3) is rated 5.0 out of 5 by 2.
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