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NDR1/2 Antibody (E-2) - Western Blotting - Image 381894
NDR1/2 抗体 (E-2): sc-271703. RAW 264. 7 (A), WEHI-231 (B), Ramos (C), Daudi (D) 和 PC-12 (E) 全细胞裂解液及 K-562 核提取物 (F) 中 NDR1/2 表达的 Western 印迹分析.
NDR1/2 抗体 (E-2): sc-271703. RAW 264. 7 (A), WEHI-231 (B), Ramos (C), Daudi (D) 和 PC-12 (E) 全细胞裂解液及 K-562 核提取物 (F) 中 NDR1/2 表达的 Western 印迹分析.

NDR1/2 抗体 (E-2): sc-271703

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寫評論提問

说明书
  • NDR1/2 抗体 E-2 是小鼠单克隆 IgG1 κ，NDR1/2抗体, 在2篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列1-100位于human物种的NDR1的N-terminus
  • NDR1/2 抗体 (E-2) 推荐用于 WB, IP, IF 和 ELISA，检测mouse, rat 和human 来源的 NDR1 and NDR2
  • 抗NDR1/2抗体（E-2）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取NDR1/2 (E-2): sc-271703的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是NDR1/2 Antibody (E-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与NDR1/2 Antibody (E-2) 打包提供（请参阅下面的订购信息）。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

附加NDR抗体，包括NDR1和NDR2

NDR1/2抗体（E-2）是一种IgG1 κ小鼠单克隆NDR1/2抗体（也称为NDR1/2抗体），可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类的NDR1/2蛋白。NDR1/2抗体（E-2）既可以是非偶联的抗NDR1/2抗体形式，也可以是多种偶联形式的抗NDR1/2抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。核Dbf2相关激酶（NDR1和NDR2）参与细胞分裂和形态的调节，并可能与肿瘤进展有关。NDR1和NDR2的氨基酸序列有86%的相似性，但它们的表达模式不同。NDR1定位于细胞核，而NDR2则呈点状细胞质分布。此外，NDR1在脾、肺和胸腺中的表达量最高，而NDR2在胃肠道中的表达量最高。然而，NDR1和NDR2都受磷酸化和Ca2+-结合蛋白S-100B的调节。NDR1和NDR2也可能在HIV-1生命周期中发挥作用。这两种蛋白都被HIV-1蛋白酶（PR）裂解，从而抑制它们的酶活性并改变NDR2的亚细胞定位。编码人类NDR1和NDR2的基因分别定位于染色体6p21和12p11.23。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

NDR1/2 抗体 (E-2) 参考文献:

  1. Ca2+ 通过自身磷酸化和上游激酶的磷酸化介导 NDR 蛋白激酶的调节机制。  |  Tamaskovic, R., et al. 2003. J Biol Chem. 278: 6710-8. PMID: 12493777
  2. 多位点磷酸化和 S100B 钙结合蛋白对 NDR2 蛋白激酶的调控。  |  Stegert, MR., et al. 2004. J Biol Chem. 279: 23806-12. PMID: 15037617
  3. 人类 Mob 蛋白调控 NDR1 和 NDR2 丝氨酸-苏氨酸激酶。  |  Devroe, E., et al. 2004. J Biol Chem. 279: 24444-51. PMID: 15067004
  4. hMOB1 蛋白激活 NDR（核 Dbf2 相关）蛋白激酶的机制。  |  Bichsel, SJ., et al. 2004. J Biol Chem. 279: 35228-35. PMID: 15197186
  5. 对机构收容的智障成人中的弓形虫和强直虫进行血清流行病学研究。  |  Huminer, D., et al. 1992. Am J Trop Med Hyg. 46: 278-81. PMID: 1558266
  6. NDR1/2在感染和炎症中的新兴作用。  |  Ye, X., et al. 2020. Front Immunol. 11: 534. PMID: 32265942
  7. NDR1/2激酶的缺失会损害内质网运输和自噬，从而导致神经变性。  |  Roşianu, F., et al. 2023. Life Sci Alliance. 6: PMID: 36446521
  8. 缺氧诱导的NDR2激活是非小细胞肺癌脑转移的基础。  |  Levallet, J., et al. 2023. Cell Death Dis. 14: 823. PMID: 38092743
  9. SENP2-NDR2-p21轴调节肺癌细胞的生长。  |  Cheng, Y., et al. 2024. Eur J Pharmacol. 978: 176761. PMID: 38908669
  10. NDR1通过USP10介导PD-L1的去泛素化，从而促进前列腺癌的免疫逃逸。  |  Fu, M., et al. 2024. Cell Commun Signal. 22: 429. PMID: 39227807
  11. NDR1/FBXO11促进β-catenin的磷酸化介导的泛素化，以抑制前列腺癌的转移。  |  Xuan, Z., et al. 2024. Int J Biol Sci. 20: 4957-4977. PMID: 39309441
  12. NDR2通过调节ULK1介导的线粒体自噬，对破骨细胞分化至关重要。  |  Kong, X., et al. 2024. JCI Insight. 10: PMID: 39561008

订购信息

产品名称产品编号规格价格数量收藏夹

NDR1/2 抗体 (E-2)

sc-271703
200 µg/ml
$316.00

NDR1/2 (E-2): m-IgG Fc BP-HRP 套装

sc-529245
200 µg Ab; 10 µg BP
$354.00

NDR1/2 (E-2): m-IgGκ BP-HRP 套装

sc-522032
200 µg Ab, 40 µg BP
$354.00

NDR1/2 (E-2): m-IgG1 BP-HRP 套装

sc-543411
200 µg Ab; 20 µg BP
$354.00

NDR1/2 抗体 (E-2) AC

sc-271703 AC
500 µg/ml, 25% agarose
$416.00

NDR1/2 抗体 (E-2) HRP

sc-271703 HRP
200 µg/ml
$316.00

NDR1/2 抗体 (E-2) FITC

sc-271703 FITC
200 µg/ml
$330.00

NDR1/2 抗体 (E-2) PE

sc-271703 PE
200 µg/ml
$343.00

NDR1/2 抗体 (E-2) Alexa Fluor® 488

sc-271703 AF488
200 µg/ml
$357.00

NDR1/2 抗体 (E-2) Alexa Fluor® 546

sc-271703 AF546
200 µg/ml
$357.00

NDR1/2 抗体 (E-2) Alexa Fluor® 594

sc-271703 AF594
200 µg/ml
$357.00

NDR1/2 抗体 (E-2) Alexa Fluor® 647

sc-271703 AF647
200 µg/ml
$357.00

NDR1/2 抗体 (E-2) Alexa Fluor® 680

sc-271703 AF680
200 µg/ml
$357.00

NDR1/2 抗体 (E-2) Alexa Fluor® 790

sc-271703 AF790
200 µg/ml
$357.00

I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-271703: NDR1/2 (E-2) mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
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Rated 5 out of 5 by from Western blotWorked great by western blot on mouse brain at 1:1000 using Odyssey fluo western blot
Date published: 2018-05-25
Rated 3 out of 5 by from just okI received a simple about a month ago,then I tested it with my simple. It worked fine with 293T transfect NDR1 but not quiet strong with four glioma samples.
Date published: 2017-11-03
Rated 4 out of 5 by from good wester blotThis antibody did work for western blot for HEK293T cell lysate.
Date published: 2017-02-14
Rated 4 out of 5 by from excellent antibodyThis antibody help me to prove the effect of chronic lead exposure on dendritic spines in rats. My paper was received successfully because of its outstanding performance. 1:2000 is good enough in western blot.
Date published: 2016-12-02
Rated 5 out of 5 by from to make the experiment more easyI'm reviewing it after my second purchase of santa's antibody. Works really quite well!
Date published: 2016-11-05
Rated 5 out of 5 by from Good Western Blot data of NDR1/2 expression in UGood Western Blot data of NDR1/2 expression in U-937 and HEL 92. -SCBT QC
Date published: 2014-06-14
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NDR1/2 抗体 (E-2) is rated 4.3 out of 5 by 6.
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