MTMR3 Antibody (A-12): sc-393779
- MTMR3 Antibody (A-12) is a mouse monoclonal IgG2a κ MTMR3 antibody provided at 200 µg/ml
- raised against amino acids 6-265 mapping near the N-terminus of MTMR3 of human origin
- MTMR3 Antibody (A-12) is recommended for detection of MTMR3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-MTMR3 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MTMR3 Antibody (A-12) for WB applications. These reagents are now offered in bundles with MTMR3 Antibody (A-12) (see ordering information below).
MTMR3 Antibody (A-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects MTMR3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-MTMR3 antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTMR3 is a member of the myotubularin family, known for its role as a phosphoinositide phosphatase, specifically hydrolyzing phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-bisphosphate. This enzymatic activity regulates cellular processes such as membrane trafficking and cytoskeletal dynamics, which are essential for maintaining cellular integrity and function. Additionally, MTMR3 interacts with other members of the MTMR family, including MTMR4, which can influence activity and localization within the cell. Understanding MTMR3 interactions and functions is vital, as mutations in related proteins can lead to severe neurological disorders, such as Charcot-Marie-Tooth disease, highlighting MTMR3′s importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTMR3 Antibody (A-12) References:
- Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway. | Blondeau, F., et al. 2000. Hum Mol Genet. 9: 2223-9. PMID: 11001925
- Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase. | Kim, SA., et al. 2003. Proc Natl Acad Sci U S A. 100: 4492-7. PMID: 12668758
- Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. | Mochizuki, Y. and Majerus, PW. 2003. Proc Natl Acad Sci U S A. 100: 9768-73. PMID: 12890864
- Phosphatidylinositol 3-phosphate indirectly activates KCa3.1 via 14 amino acids in the carboxy terminus of KCa3.1. | Srivastava, S., et al. 2006. Mol Biol Cell. 17: 146-54. PMID: 16251351
- Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2. | Berger, P., et al. 2006. Hum Mol Genet. 15: 569-79. PMID: 16399794
- Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. | Lorenzo, O., et al. 2006. J Cell Sci. 119: 2953-9. PMID: 16787938
- Mutations in the MTM1 gene implicated in X-linked myotubular myopathy. ENMC International Consortium on Myotubular Myopathy. European Neuro-Muscular Center. | Laporte, J., et al. 1997. Hum Mol Genet. 6: 1505-11. PMID: 9305655
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTMR3 Antibody (A-12) | sc-393779 | 200 µg/ml | $322.00 | |||
MTMR3 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-530578 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTMR3 Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-524086 | 200 µg Ab, 40 µg BP | $361.00 | |||
MTMR3 Antibody (A-12): m-IgG2a BP-HRP Bundle | sc-547524 | 200 µg Ab; 10 µg BP | $361.00 | |||
MTMR3 Antibody (A-12) AC | sc-393779 AC | 500 µg/ml, 25% agarose | $424.00 | |||
MTMR3 Antibody (A-12) HRP | sc-393779 HRP | 200 µg/ml | $322.00 | |||
MTMR3 Antibody (A-12) FITC | sc-393779 FITC | 200 µg/ml | $336.00 | |||
MTMR3 Antibody (A-12) PE | sc-393779 PE | 200 µg/ml | $349.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 488 | sc-393779 AF488 | 200 µg/ml | $364.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 546 | sc-393779 AF546 | 200 µg/ml | $364.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 594 | sc-393779 AF594 | 200 µg/ml | $364.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 647 | sc-393779 AF647 | 200 µg/ml | $364.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 680 | sc-393779 AF680 | 200 µg/ml | $364.00 | |||
MTMR3 Antibody (A-12) Alexa Fluor® 790 | sc-393779 AF790 | 200 µg/ml | $364.00 |