Date published: 2025-9-10

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MSH2 抗体 (25D12): sc-56163

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说明书
  • MSH2 抗体 25D12 是小鼠单克隆 IgG1, 在5篇文献中引用,提供 250 µl supernatant
  • 针对全长MSH2,human起源
  • 推荐用于 human 来源的MSH2 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前,我们还没有完成MSH2 抗体 (25D12)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

MSH2抗体(25D12)是一种IgG1小鼠单克隆MSH2抗体,可通过WB、IP、IF、IHC(P)和ELISA检测人源的MSH2。MSH2抗体(25D12)可以非偶联抗MSH2抗体形式提供。DNA错配修复基因与遗传性非息肉病性大肠癌(HNPCC)有关的发现,引起了人们对DNA错配修复机制的极大兴趣。最初,在HNPCC中高频证明了细菌DNA错配修复基因MutS和MutL的同源物MSH2和MLH1的遗传性突变,并显示与微卫星不稳定性有关。10%至45%的胰腺癌、胃癌、乳腺癌、卵巢癌和小细胞肺癌也显示微卫星不稳定性的证明,这被解释为表明DNA错配修复不仅限于HNPCC肿瘤,而且是肿瘤发生或进展的共同特征。已鉴定出原核MutL基因的两个额外同源物,分别命名为PMS1和PMS2,并显示在HNPCC患者的生殖系中发生突变。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MSH2 抗体 (25D12) 参考文献:

  1. 结直肠癌患者MLH1和MSH2突变检测的转换分析。  |  Casey, G., et al. 2005. JAMA. 293: 799-809. PMID: 15713769
  2. 在1721个疑似遗传性非息肉病性结直肠癌的德国家庭中,MSH2和MLH1的突变谱和频率。  |  Mangold, E., et al. 2005. Int J Cancer. 116: 692-702. PMID: 15849733
  3. 林奇综合征中MLH1、MSH2和MSH6基因的种系突变与癌症风险的关系。  |  Bonadona, V., et al. 2011. JAMA. 305: 2304-10. PMID: 21642682
  4. 大规模并行功能测试MSH2错义变异,确定林奇综合征风险。  |  Jia, X., et al. 2021. Am J Hum Genet. 108: 163-175. PMID: 33357406
  5. MSH2 MSH3表达升高会干扰体内DNA代谢。  |  Medina-Rivera, M., et al. 2023. Nucleic Acids Res. 51: 12185-12206. PMID: 37930834
  6. 酵母在启动 DNA 错配修复过程中与 MLH1, PMS1 和 MSH2 的相互作用  |  Prolla, TA., et al. 1994. Science. 265: 1091-3. PMID: 8066446
  7. 遗传性非息肉病结肠癌中两种 PMS 同源物的突变。  |  Nicolaides, NC., et al. 1994. Nature. 371: 75-80. PMID: 8072530
  8. 错配修复与癌症  |  Palombo, F., et al. 1994. Nature. 367: 417. PMID: 8107798
  9. 遗传性结肠癌中的 mutL 同源物突变。  |  Papadopoulos, N., et al. 1994. Science. 263: 1625-9. PMID: 8128251
  10. DNA 错配修复基因同源物 hMLH1 的突变与遗传性非息肉病结肠癌缔合作用。  |  Bronner, CE., et al. 1994. Nature. 368: 258-61. PMID: 8145827
  11. 人类大肠癌易感基因座的基因图谱。  |  Peltomäki, P., et al. 1993. Science. 260: 810-2. PMID: 8484120
  12. 简单重复序列中无处不在的体细胞突变揭示了结肠癌发生的新机制。  |  Ionov, Y., et al. 1993. Nature. 363: 558-61. PMID: 8505985

订购信息

产品名称产品编号规格价格数量收藏夹

MSH2 抗体 (25D12)

sc-56163
250 µl supernatant
$316.00

Is this MSH2 Antibody (25D12): sc-56163 mouse monoclonal antibody make reactivity on human tissue?

Asked by: OzdeGokbayrak
Thank you for your question. MSH2 Antibody (25D12): sc-56163 is recommended for detection of MSH2 of human origin by WB, IP, IF, IHC(P) and ELISA.
Answered by: Tech Support Europe
Date published: 2024-03-28

Can sc-56163: MSH2 (25D12) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Professor Griffin
Thank you for your question. Yes, sc-56163: MSH2 (25D12) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for Western BlotThis antibody has been used for western blotting in published research. -SCBT QC
Date published: 2023-09-14
Rated 4 out of 5 by from Strong band in WB in HeLa whole cell lysateStrong band in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-07-07
Rated 4 out of 5 by from Robust signal in WB in ARobust signal in WB in A-431 and SW480 whole cell lysates and A-431, U-937, MOLT-4 and SW480 nuclear extracts. -SCBT QC
Date published: 2015-02-06
Rated 4 out of 5 by from WB publishable data with human colorectalWB publishable data with human colorectal cancer cell lines (SW480, LoVo, HCT116), Lymphocytes, immortalized lymphocytes, colon cancer cell lines (SW480, LoVo, HCT116) - SCBT Publication Review
Date published: 2014-06-23
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MSH2 抗体 (25D12) is rated 4.3 out of 5 by 4.
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