Date published: 2025-9-7

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MLH3 抗体 (H-2): sc-25313

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说明书
  • MLH3 抗体 H-2 是小鼠单克隆 IgG1 κ,MLH3抗体, 在6篇文献中引用,规格为200 µg/ml
  • 免疫human物种的MLH3的氨基酸1228-1453
  • MLH3 抗体 (H-2) 推荐用于WB, IP, IF 和 ELISA,检测mouse, rat, human 来源的 MLH3
  • 抗MLH3抗体(H-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MLH3 (H-2): sc-25313免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是MLH3 Antibody (H-2) for WB applications. 的首选辅助检测试剂,这些试剂现与MLH3 Antibody (H-2) 打包提供(请参阅下面的订购信息)。

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関連項目

MLH3抗体(H-2)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人源MLH3蛋白。MLH3 (H-2) 抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。MLH3 蛋白在 DNA 错配修复 (MMR) 途径中起着关键作用,该途径对于在 DNA 复制过程中保持基因组稳定性至关重要。MLH3主要位于细胞核中,与MLH1形成异源二聚体,对识别和修复DNA错配至关重要。MLH3在细胞核中的定位使其能够与参与MMR的其他关键蛋白直接相互作用,例如负责检测错配的MSH2和MSH3。MLH3在细胞核中的有效功能至关重要,因为MLH3的缺陷会导致微卫星不稳定,并可能与遗传性非息肉病性结直肠癌(HNPCC)和其他恶性肿瘤有关。在研究中使用抗MLH3抗体(H-2)可以为DNA修复机制和癌症生物学中的MMR缺陷提供宝贵的见解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MLH3 抗体 (H-2) 参考文献:

  1. 真核 DNA 错配修复。  |  Kolodner, RD. and Marsischky, GT. 1999. Curr Opin Genet Dev. 9: 89-96. PMID: 10072354
  2. Mlh1与Pms2缺陷小鼠的突变表型不同。  |  Yao, X., et al. 1999. Proc Natl Acad Sci U S A. 96: 6850-5. PMID: 10359802
  3. MLH3:与哺乳动物微卫星不稳定性有关的 DNA 错配修复基因。  |  Lipkin, SM., et al. 2000. Nat Genet. 24: 27-35. PMID: 10615123
  4. MutL同源物Mlh2p和Mlh3p在去除芽殖酵母中的移帧中间产物过程中发挥不同的体内作用。  |  Harfe, BD., et al. 2000. Curr Biol. 10: 145-8. PMID: 10679328
  5. 错配修复与癌症  |  Palombo, F., et al. 1994. Nature. 367: 417. PMID: 8107798
  6. 遗传性结肠癌中的 mutL 同源物突变。  |  Papadopoulos, N., et al. 1994. Science. 263: 1625-9. PMID: 8128251
  7. 人类 MSH3 基因的基因组组织和表达。  |  Watanabe, A., et al. 1996. Genomics. 31: 311-8. PMID: 8838312
  8. Mlh1, Pms1 和 Pms2 DNA 错配修复缺陷小鼠的肿瘤易感性和自发性突变。  |  Prolla, TA., et al. 1998. Nat Genet. 18: 276-9. PMID: 9500552

订购信息

产品名称产品编号规格价格数量收藏夹

MLH3 抗体 (H-2)

sc-25313
200 µg/ml
$316.00

MLH3 (H-2): m-IgG Fc BP-HRP 套装

sc-526647
200 µg Ab; 10 µg BP
$354.00

MLH3 (H-2): m-IgG1 BP-HRP 套装

sc-532020
200 µg Ab; 20 µg BP
$354.00

MLH3 抗体 (H-2) AC

sc-25313 AC
500 µg/ml, 25% agarose
$416.00

MLH3 抗体 (H-2) HRP

sc-25313 HRP
200 µg/ml
$316.00

MLH3 抗体 (H-2) FITC

sc-25313 FITC
200 µg/ml
$330.00

MLH3 抗体 (H-2) PE

sc-25313 PE
200 µg/ml
$343.00

MLH3 抗体 (H-2) Alexa Fluor® 488

sc-25313 AF488
200 µg/ml
$357.00

MLH3 抗体 (H-2) Alexa Fluor® 546

sc-25313 AF546
200 µg/ml
$357.00

MLH3 抗体 (H-2) Alexa Fluor® 594

sc-25313 AF594
200 µg/ml
$357.00

MLH3 抗体 (H-2) Alexa Fluor® 647

sc-25313 AF647
200 µg/ml
$357.00

MLH3 抗体 (H-2) Alexa Fluor® 680

sc-25313 AF680
200 µg/ml
$357.00

MLH3 抗体 (H-2) Alexa Fluor® 790

sc-25313 AF790
200 µg/ml
$357.00

Is it available carrier free?

Asked by: Alex
Thank you for your question. For information on custom variants of this antibody, please contact our technical service team directly.
Answered by: Tech Support Europe
Date published: 2023-09-22

Will this Ab work with IHC-P? If so which HIER do you recommend. I tried it on some CRC tissue and used Tris/EDTA HIER, and dilution of 1:100. I didnt get any positive staining whatsoever. Do you have any recommendations please.

Asked by: RayKay
Thank you for your question. MLH3 Antibody (H-2) is only recommended for detection of MLH3 of mouse, rat, human origin by WB, IP, IF and ELISA. Based on our tests with this product it is not suitable for IHC or IHC(P) and does not produce consistent results in such assays.
Answered by: Tech Support Europe
Date published: 2022-09-05

What is the recommended starting dilution for Western blot for sc-25313: MLH3 (H-2) monoclonal antibody?

Asked by: Dr Ninau Qelp
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 3 out of 5 by from Positive Western blot data with human recombinantPositive Western blot data with human recombinant MLH3 fusion protein. -SCBT QC
Date published: 2015-06-06
Rated 5 out of 5 by from Publishable IF data with HeLa and HCT116Publishable IF data with HeLa and HCT116 - SCBT Publication Review
Date published: 2015-04-02
Rated 5 out of 5 by from This antibody was used in a publication forThis antibody was used in a publication for IP and WB on human Sf9 cells - SCBT Publication Review
Date published: 2015-02-06
Rated 5 out of 5 by from WB publishable data with human hPMS1WB publishable data with human hPMS1, hPMS2, hMLH1 and hMLH3 - SCBT Publication Review
Date published: 2013-10-17
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MLH3 抗体 (H-2) is rated 4.6 out of 5 by 5.
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