Date published: 2025-9-6
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MEL-1A/B-R Antibody (B-8) - Western Blotting - Image 362098
MEL-1A/B-R 抗体 (B-8): sc-398788. Jurkat (A), Neuro-2A (B) 和 C6 (C) 全细胞裂解液中 MEL-1A/B-R 表达的 Western 印迹分析.
MEL-1A/B-R 抗体 (B-8): sc-398788. Jurkat (A), Neuro-2A (B) 和 C6 (C) 全细胞裂解液中 MEL-1A/B-R 表达的 Western 印迹分析.

MEL-1A/B-R 抗体 (B-8): sc-398788

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说明书
  • MEL-1A/B-R抗体(B-8)是小鼠单克隆IgM κ, 在11篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列161-280位于human物种的MEL-1A-R的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的MEL-1A-R and MEL-1B-R WB, IP, IF 和 ELISA检测
  • 关于如何获取MEL-1A/B-R (B-8): sc-398788的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是MEL-1A/B-R Antibody (B-8) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与MEL-1A/B-R Antibody (B-8) 搭配使用（请参阅下面的订购信息）。有关其它 m-IgGκ BP 结合物，请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

附加MEL-1抗体，包括和MEL-1A-R

MEL-1A/B-R抗体（B-8）是一种IgM κ小鼠单克隆MEL-1A/B-R抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和酶联免疫吸附试验（ELISA）检测小鼠、大鼠和人类来源的MEL-1A-R和MEL-1B-R。MEL-1A/B-R抗体（B-8）为非偶联形式的抗MEL-1A/B-R抗体。褪黑素（Mel）是由松果体分泌的一种激素，它在昼夜节律的响应下在夜间表达。褪黑素被认为参与调节生殖生理发育和性成熟的进程，也被认为在肿瘤发生中起作用。褪黑素受体MEL-1A-R和MEL-1B-R是鸟苷酸结合调节蛋白（G蛋白）偶联受体超家族的成员。通过褪黑素受体的信号传导在激活百日咳毒素（PTX）敏感的G蛋白后抑制腺苷酸环化酶并刺激磷脂酶Cb。MEL-1A-R可能参与调节生物钟。然而，MEL-1A-R和MEL-1B-R都涉及响应褪黑素控制细胞生长。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MEL-1A/B-R 抗体 (B-8) 参考文献:

  1. 人类 Mel(1a)-褪黑激素受体与 G(i)的紧密结合：预偶联和组成活性。  |  Roka, F., et al. 1999. Mol Pharmacol. 56: 1014-24. PMID: 10531408
  2. 人类 Mel1a 褪黑激素受体通过 G（i2）, G（i3）和 G（q/11）蛋白发出双重信号。  |  Brydon, L., et al. 1999. Mol Endocrinol. 13: 2025-38. PMID: 10598579
  3. 人类葡萄膜黑色素细胞和黑色素瘤细胞中的褪黑激素受体。  |  Roberts, JE., et al. 2000. J Pineal Res. 28: 165-71. PMID: 10739303
  4. 褪黑激素与乳腺病理生长  |  Cos, S. and Sánchez-Barceló, EJ. 2000. Front Neuroendocrinol. 21: 133-70. PMID: 10764528
  5. 褪黑激素与性激素的相互关系--综述。  |  Luboshitzky, R. and Lavie, P. 1999. J Pediatr Endocrinol Metab. 12: 355-62. PMID: 10821215
  6. 大鼠附睾中褪黑激素受体介导的信号传导的生物学基础和可能的生理意义  |  Shiu, SY., et al. 2000. Biol Signals Recept. 9: 172-87. PMID: 10899702
  7. 褪黑激素与生物节律  |  Pévet, P. 2000. Biol Signals Recept. 9: 203-12. PMID: 10899705
  8. 褪黑素受体1B基因rs10830963多态性、抑郁症状和血糖特征。  |  Haljas, K., et al. 2018. Ann Med. 50: 704-712. PMID: 30089436
  9. 长期黑暗环境暴露可通过减少褪黑素受体1A和芳香化酶诱导多囊卵巢综合征（PCOS）中的高雄激素血症。  |  Chu, W., et al. 2022. Front Cell Dev Biol. 10: 954186. PMID: 36353509
  10. 褪黑素受体1B基因多态性的作用及其对妊娠糖尿病中葡萄糖转运调节的影响。  |  Wei, L., et al. 2023. J Zhejiang Univ Sci B. 24: 78-88. PMID: 36632752
  11. 植入失败和流产的不孕妇女的褪黑素受体1B和皮质类固醇受体多态性。  |  Robeva, R., et al. 2023. Front Biosci (Landmark Ed). 28: 122. PMID: 37395040
  12. 褪黑素通过小鼠褪黑素受体1A/B基因敲除减轻与衰老有关的心力衰竭。  |  Feng, Z., et al. 2024. Heliyon. 10: e38098. PMID: 39347399

订购信息

产品名称产品编号规格价格数量收藏夹

MEL-1A/B-R 抗体 (B-8)

sc-398788
200 µg/ml
$316.00

MEL-1A/B-R (B-8): m-IgGκ BP-HRP 套装

sc-524486
200 µg Ab, 40 µg BP
$354.00

any blocking peptide available for MEL-1A/B-R? Why not separate antibody for specific MT1 and MT2 receptors?

Asked by: Tavleen
Thank you for your question. Unfortunately there is no blocking peptide available for this antibody as it was not made against a peptide. We would suggest using a negative control using a control IgG. We do not offer separate antibodies for the two receptors currently.
Answered by: Tech Service
Date published: 2017-06-15

Are there any issues with using sc-398788: MEL-1A/B-R (B-8) mouse monoclonal primary antibody on mouse samples?

Asked by: Trav11
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-398788 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Suitable for IFThe antibody turned out to be very useful for both purposes - WB and IF.
Date published: 2021-07-30
Rated 5 out of 5 by from great antibodyThis was tested for hRMECs. This work incredibly well with high specificity and very low background.Recommend use dilution 1:200.
Date published: 2021-01-28
Rated 1 out of 5 by from No success.We tested this antibody with pancreas and brain from mouse and rat. Unfortunately we did not detect the protein.
Date published: 2019-09-19
Rated 5 out of 5 by from Good antibody!1:200 diluted for wb of rat protein,the band is quite strong
Date published: 2019-02-25
Rated 5 out of 5 by from Great antibodyWe got obtained specific band is very clear and powerful signal.Knowledge of the sensitivity and specificity of MEL-1A/B-R Antibody leads to their more rational selection.
Date published: 2017-10-09
Rated 5 out of 5 by from worked wellThis was tested for mouse spleen sections. This work incredibly well with high specificity and very low background.Recommend use dilution 1:250.
Date published: 2017-08-12
Rated 4 out of 5 by from Happy monoclonal antibodyWe used MEL-1A-R monoclonal antibody in the sample mouse cells, when WB dilution 1:500 most obvious effect, we are very happy.
Date published: 2017-05-18
Rated 5 out of 5 by from Strong single bandsStrong single bands seen in Western Blot with no background or additional bands.
Date published: 2017-03-05
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MEL-1A/B-R 抗体 (B-8) is rated 4.5 out of 5 by 12.
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