Date published: 2025-9-9

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MCR 抗体 (H10E4C9F): sc-53000

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说明书
  • MCR 抗体 H10E4C9F 是小鼠单克隆 IgG1 κ,MCR抗体, 在4篇文献中引用,规格为200 µg/ml
  • 与醛固酮3结合牛血清白蛋白
  • MCR 抗体 (H10E4C9F) 推荐用于 WB, IP, IF 和 IHC(P),检测mouse, rat 和human 来源的 MCR
  • 抗MCR抗体(H10E4C9F)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MCR (H10E4C9F): sc-53000免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 MCR 抗体 (H10E4C9F) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MCR 抗体 (H10E4C9F) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MCR抗体(H10E4C9F)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和石蜡包埋切片免疫组织化学(IHCP)检测小鼠、大鼠和人类来源的MCR蛋白。MCR (H10E4C9F) 抗体有非结合型和多种结合型可供选择,包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合物。盐皮质激素受体(MCR)通过调节醛固酮等盐皮质激素的作用,在调节电解质平衡和血压方面发挥着至关重要的作用。MCR主要位于上皮组织中,对于维持体内平衡至关重要的钠、钾和氢离子的运输至关重要。与醛固酮结合后,MCR会激活基因转录,从而增加参与离子运输的蛋白质的表达。MCR的调节机制非常复杂,涉及负向自调节和正向自调节机制,以确保MCR活性能够根据生理需求进行微调。此外,MCR与热休克蛋白90(HSP90)的相互作用对于其正常功能至关重要,因为这种关联对于激素结合和随后的受体激活是必不可少的。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MCR 抗体 (H10E4C9F) 参考文献:

  1. 矿物皮质激素的细胞作用机制。  |  Johnson, JP. 1992. Pharmacol Ther. 53: 1-29. PMID: 1322539
  2. 克隆人矿皮质激素受体互补 DNA:与糖皮质激素受体在结构和功能上的亲缘关系。  |  Arriza, JL., et al. 1987. Science. 237: 268-75. PMID: 3037703
  3. 矿物质皮质激素受体激活与心房纤维化  |  Brown, NJ. 2019. Hypertension. 73: 294-295. PMID: 30595119
  4. 柚皮苷的降压作用是通过抑制矿物皮质激素受体(MCR)/血管紧张素转换酶(ACE)/肾损伤分子(Kim-1)信号通路来实现的。  |  Oyagbemi, AA., et al. 2020. Eur J Pharmacol. 880: 173142. PMID: 32422184
  5. 治疗糖尿病肾病的矿物质皮质激素受体拮抗剂。  |  Rossing, P. 2020. Clin J Am Soc Nephrol. 15: 1696-1698. PMID: 33239412
  6. 矿物质皮质激素受体拮抗剂在糖尿病肾病中的作用--机理和治疗效果。  |  Barrera-Chimal, J., et al. 2022. Nat Rev Nephrol. 18: 56-70. PMID: 34675379
  7. 非奈酮拮抗矿质皮质激素受体可减轻大鼠已形成的肺动脉高压  |  Tu, L., et al. 2022. Hypertension. 79: 2262-2273. PMID: 35979822
  8. Schwann细胞中的盐皮质激素受体敲除改变了髓鞘厚度。  |  González-Mayoral, A., et al. 2023. J Endocrinol. 258: PMID: 37195271
  9. 皮质类固醇受体的自身调节。如何, 何时, 何地, 为何?  |  Schmidt, TJ. and Meyer, AS. 1994. Receptor. 4: 229-57. PMID: 7894339
  10. 遗传性矿皮质激素性高血压。  |  White, PC. 1996. Hypertension. 28: 927-36. PMID: 8952579
  11. 热休克蛋白 90 结合剂格尔德霉素对矿质皮质激素和糖皮质激素受体功能的抑制。  |  Bamberger, CM., et al. 1997. Mol Cell Endocrinol. 131: 233-40. PMID: 9296382
  12. 类固醇受体基因的转录调控。  |  Kumar, MV. and Tindall, DJ. 1998. Prog Nucleic Acid Res Mol Biol. 59: 289-306. PMID: 9427846

订购信息

产品名称产品编号规格价格数量收藏夹

MCR 抗体 (H10E4C9F)

sc-53000
200 µg/ml
$316.00

MCR (H10E4C9F): m-IgG Fc BP-HRP 套装

sc-526757
200 µg Ab; 10 µg BP
$354.00

MCR (H10E4C9F): m-IgG1 BP-HRP 套装

sc-532130
200 µg Ab; 20 µg BP
$354.00

MCR 抗体 (H10E4C9F) AC

sc-53000 AC
500 µg/ml, 25% agarose
$416.00

MCR 抗体 (H10E4C9F) HRP

sc-53000 HRP
200 µg/ml
$316.00

MCR 抗体 (H10E4C9F) FITC

sc-53000 FITC
200 µg/ml
$330.00

MCR 抗体 (H10E4C9F) PE

sc-53000 PE
200 µg/ml
$343.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 488

sc-53000 AF488
200 µg/ml
$357.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 546

sc-53000 AF546
200 µg/ml
$357.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 594

sc-53000 AF594
200 µg/ml
$357.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 647

sc-53000 AF647
200 µg/ml
$357.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 680

sc-53000 AF680
200 µg/ml
$357.00

MCR 抗体 (H10E4C9F) Alexa Fluor® 790

sc-53000 AF790
200 µg/ml
$357.00

Does epitope mapping at the N-terminus of MCR ?

Asked by: MajaWü
Thank you for your question. This antibody was raised against aldosterone 3 coupled to bovine serum albumin. The exact binding epitope has not been mapped. If you have any further questions, please contact Technical Service.
Answered by: SCBT Heidelberg Support
Date published: 2024-03-28

Can MCR (H10E4C9F): sc-53000 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Cweed
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, MCR (H10E4C9F): sc-53000 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-08-20
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Rated 4 out of 5 by from MCR for Rat kidneyI used sc-53000 for Rat kidney and result is OK, bind is at 70kDa. Look is very specific but MW is low than 102MW. Do you think it is OK?
Date published: 2017-10-13
Rated 3 out of 5 by from good work !I received this Ab to do western blot, it is good for our experiment diluted as high concertration
Date published: 2017-08-01
Rated 5 out of 5 by from 以前买过此款抗体,好用以前用过此款抗体的多抗,我在293细胞中瞬时转染该蛋白的表达质粒,24小时即可检测出该蛋白的过表达效果,非常明显。
Date published: 2017-01-24
Rated 1 out of 5 by from Did not work for me.I received this as a free sample. In my translocation experiment (IF), I could see no difference with and without compound. The region stained wasn't even nuclear.
Date published: 2016-12-06
Rated 4 out of 5 by from Good for Western blotting to detect endogenousGood for Western blotting to detect endogenous level of MCR, although a high concentration is generally required.
Date published: 2015-10-14
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MCR 抗体 (H10E4C9F) is rated 3.4 out of 5 by 5.
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