Date published: 2025-9-7

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MALT1 抗体 (B-12): sc-46677

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说明书
  • MALT1抗体(B-12)是小鼠单克隆IgG1 κ, 在41篇文献中引用,规格为200 µg/ml
  • 免疫human物种的MALT1的氨基酸525-824
  • MALT1 抗体 (B-12) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 MALT1
  • MALT1抗体(B-12)可与Alexa Fluor® 546Alexa Fluor® 594结合,用于WB(RGB)、IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取MALT1 (B-12): sc-46677免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRPm-IgG1 BP-HRP 是 MALT1 抗体 (B-12) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与MALT1 抗体 (B-12) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

MALT1抗体(B-12)是一种鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、免疫组织化学和酶联免疫吸附测定(ELISA)检测人类MALT1。MALT1 单克隆抗体(B-12)有结合和非结合两种形式,可满足各种实验需求。粘膜相关淋巴组织淋巴瘤易位基因1(MALT1)在免疫反应中起着至关重要的作用,特别是在NFκB信号通路的激活方面,而该通路对于细胞存活和增殖至关重要。MALT1主要位于细胞质中,参与细胞凋亡和炎症的调节。这种细胞质定位使MALT1能够与各种信号分子相互作用,促进信号传导,从而促进淋巴细胞的活化和分化。MALT1(B-12)抗体与某些淋巴瘤的发病机制有关,特别是与API2-MALT1融合蛋白相关的淋巴瘤,这种融合蛋白是由染色体易位引起的。这种融合蛋白不仅增强了MALT1的致癌潜力,还破坏了正常的细胞凋亡过程,导致淋巴组织中细胞存活和增殖增加。MALT1 mRNA在预B细胞、成熟B细胞和浆细胞中表达,这凸显了MALT1在免疫系统发育和功能中的重要性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

MALT1 抗体 (B-12) 参考文献:

  1. 凋亡抑制基因API2和一个新的18q基因MLT在与粘膜相关淋巴组织淋巴瘤相关的t(11;18)(q21;q21)中反复重排。  |  Dierlamm, J., et al. 1999. Blood. 93: 3601-9. PMID: 10339464
  2. 粘膜相关淋巴组织低级别 B 细胞淋巴瘤中发现的 t(11;18) (q21;q21) 涉及一个新基因,即位于 18q21 的 MALT1。  |  Akagi, T., et al. 1999. Oncogene. 18: 5785-94. PMID: 10523859
  3. 鉴定副天冬酶和元天冬酶:两个古老的类天冬酶蛋白家族,其中一个在 MALT 淋巴瘤中发挥关键作用。  |  Uren, AG., et al. 2000. Mol Cell. 6: 961-7. PMID: 11090634
  4. API2/MALT1 融合产物可能会通过抑制细胞凋亡而导致生殖中心 B 细胞淋巴瘤。  |  Stoffel, A. and Le Beau, MM. 2001. Hum Hered. 51: 1-7. PMID: 11096264
  5. 涉及粘膜相关淋巴组织淋巴瘤的API2-MALT1融合转录本:使用福尔马林固定石蜡包埋标本进行多重RT-PCR检测。  |  Inagaki, H., et al. 2001. Am J Pathol. 158: 699-706. PMID: 11159207
  6. Bcl10和MALT1是麦芽淋巴瘤染色体易位的独立靶点,它们在新型NF-kappa B信号通路中相互合作。  |  Lucas, PC., et al. 2001. J Biol Chem. 276: 19012-9. PMID: 11262391
  7. T(11;18)(q21;q21)与表达核 BCL10 的晚期粘膜相关淋巴组织淋巴瘤有关。  |  Liu, H., et al. 2001. Blood. 98: 1182-7. PMID: 11493468
  8. GLS1 介导的谷氨酰胺溶解在 MALT1 蛋白酶的控制下促进了牛皮癣的发病。  |  Xia, X., et al. 2020. J Clin Invest. 130: 5180-5196. PMID: 32831293
  9. 癌症中的 Paracaspase MALT1。  |  Gomez Solsona, B., et al. 2022. Biomedicines. 10: PMID: 35203553
  10. Gab2-MALT1轴调节血栓性炎症和深静脉血栓形成。  |  Kondreddy, V., et al. 2022. Blood. 140: 1549-1564. PMID: 35895897
  11. 癌基因诱导的 MALT1 蛋白酶活性驱动恶性淋巴瘤转录后基因表达。  |  Wimberger, N., et al. 2023. Blood. 142: 1985-2001. PMID: 37623434
  12. PRRSV 利用 MALT1 调控的自噬通量来切换病毒传播和储备。  |  Gu, H., et al. 2024. Autophagy. 20: 2697-2718. PMID: 39081059

订购信息

产品名称产品编号规格价格数量收藏夹

MALT1 抗体 (B-12)

sc-46677
200 µg/ml
$316.00

MALT1 (B-12): m-IgG Fc BP-HRP 套装

sc-526722
200 µg Ab; 10 µg BP
$354.00

MALT1 (B-12): m-IgG1 BP-HRP 套装

sc-532095
200 µg Ab; 20 µg BP
$354.00

MALT1 抗体 (B-12) Alexa Fluor® 546

sc-46677 AF546
200 µg/ml
$357.00

MALT1 抗体 (B-12) Alexa Fluor® 594

sc-46677 AF594
200 µg/ml
$357.00

MALT1 抗体 (B-12) Alexa Fluor® 680

sc-46677 AF680
200 µg/ml
$357.00

MALT1 抗体 (B-12) Alexa Fluor® 790

sc-46677 AF790
200 µg/ml
$357.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with MALT1 (B-12): sc-46677?

Asked by: cjMara
We recommend using one of our our exclusive Mouse IgG Binding Proteins (m-IgGκ) conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support 10
Date published: 2017-01-11

I am using MALT1 (B-12): sc-46677 to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: cjMara
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support 10
Date published: 2017-01-11
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Rated 5 out of 5 by from ProfUnique band was detected in human cell lines with non-nonspecific band.
Date published: 2022-11-22
Rated 5 out of 5 by from Great signalsB-12 was much better than D-1 in terms of signal intensity and repeatability.
Date published: 2017-10-03
Rated 5 out of 5 by from Great productSuperb western blot data; strong signal; also great IHC staining
Date published: 2017-01-29
Rated 5 out of 5 by from Provides good IHC(P) dataThe MALT1 Antibody (B-12): sc-46677 performs well for IHC with formalin fixed, paraffin-embedded tissue section showing membrane localized staining. This antibody has been cited over 10 times for further verification.
Date published: 2017-01-13
Rated 5 out of 5 by from Exceptional immunoperoxidase membrane stainingExceptional immunoperoxidase membrane staining in formalin fixed, paraffin-embedded human malignant lymphoma. -SCBT QC
Date published: 2015-05-17
Rated 5 out of 5 by from Clean bands in western blot analysis of MALT1Clean bands in western blot analysis of MALT1 expression in Jurkat and Daudi whole cell lysates. -SCBT QC
Date published: 2015-05-04
Rated 5 out of 5 by from Published western blot data using HEK293Published western blot data using HEK293 cell lysates. -SCBT Publication Review
Date published: 2015-04-13
Rated 5 out of 5 by from Immunoperoxidase staining of MALT lymphoma cellsImmunoperoxidase staining of MALT lymphoma cells. -SCBT Publication Review
Date published: 2015-03-25
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MALT1 抗体 (B-12) is rated 5.0 out of 5 by 9.
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