Date published: 2025-9-7
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karyopherin α1 Antibody (187.1) - Western Blotting - Image 368203
karyopherin α1抗体 (187. 1): sc-101292. HeLa (A), K-562 (B), HuT 78 (C), RAW 264. 7 (D), NIH/3T3 (E) 和 PC-12 (F) 全细胞裂解液中 karyopherin α1 表达的 Western 印迹分析.
karyopherin α1抗体 (187. 1): sc-101292. HeLa (A), K-562 (B), HuT 78 (C), RAW 264. 7 (D), NIH/3T3 (E) 和 PC-12 (F) 全细胞裂解液中 karyopherin α1 表达的 Western 印迹分析.

karyopherin α1 抗体 (187.1): sc-101292

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说明书
  • karyopherin alpha 1 抗体 187.1 是小鼠单克隆 IgG1 κ，karyopherin α1抗体, 在17篇文献中引用，规格为100 µg/ml
  • 免疫human物种的重组karyopherin α1
  • 推荐用于 mouse, rat 和 human 来源的karyopherin α1 WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取karyopherin α1 (187.1): sc-101292的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前，我们还没有完成karyopherin α1 抗体 (187.1)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 karyopherin 抗体 包括 karyopherin 13, karyopherin α 1, karyopherin α 2, karyopherin α 5, karyopherin α 6, karyopherin β 1, karyopherin β 2, karyopherin β 2B, karyopherin β 3和karyopherin α 3

karyopherin α1抗体（187.1）是一种IgG1 κ小鼠单克隆karyopherin alpha 1抗体（也称为KPNA1抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类来源的karyopherin alpha 1蛋白。karyopherin α1抗体（187.1）为非偶联的抗karyopherin alpha 1抗体。核内蛋白质运输是一个选择性、多步骤的过程，涉及多种细胞质因子。蛋白质必须被识别为导入底物，以ATP依赖的方式停靠在核孔复合物上并穿过核膜。在识别和停靠过程中起核心作用的两个细胞质因子是karyopherin α1和karyopherin β1亚基。Karyopherin α1负责识别和定位注定要进入细胞核的底物，而karyopherin β1则作为适配器，将karyopherin α1/底物复合物连接到核膜上的称为核孔蛋白的停靠蛋白上。已显示karyopherin α2与Epstein-Barr病毒核抗原1（EBNA1）形成复合物。某些RNA结合蛋白由karyopherin β2导入细胞核，而karyopherin β3似乎参与某些核糖体蛋白的导入。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

karyopherin α1 抗体 (187.1) 参考文献:

  1. 鉴定猪组织中的核仁蛋白α1和α7相互作用蛋白。  |  Park, KE., et al. 2012. PLoS One. 7: e38990. PMID: 22720010
  2. Karyopherin Alpha 蛋白调控少突胶质细胞分化  |  Laitman, BM., et al. 2017. PLoS One. 12: e0170477. PMID: 28107514
  3. 乙酰化调节肺腺癌中 karyopherin alpha 2 的核细胞质分布和致癌功能。  |  Feng, HP., et al. 2023. Biochem Biophys Res Commun. 659: 96-104. PMID: 37060831
  4. 骨骼肌 karyopherin α1 和 α2 与肌肉生成和胰岛素作用的关系。  |  Karczewska-Kupczewska, M., et al. 2024. Pol Arch Intern Med. 134: PMID: 38980143
  5. 蛋白质从细胞核输出需要 GTP 酶 Ran 和 GTP 水解。  |  Moroianu, J. and Blobel, G. 1995. Proc Natl Acad Sci U S A. 92: 4318-22. PMID: 7753805
  6. 以前发现的功能不确定的蛋白质是 karyopherin alpha，它与 karyopherin beta 一起在核孔复合体中对接进口底物。  |  Moroianu, J., et al. 1995. Proc Natl Acad Sci U S A. 92: 2008-11. PMID: 7892216
  7. Ran 结合域促进 Ran 与 p97/beta karyopherin 的相互作用，将核导入的对接和转运步骤联系起来。  |  Lounsbury, KM., et al. 1996. J Biol Chem. 271: 2357-60. PMID: 8576188
  8. karyopherin alpha 与 karyopherin beta 的结合位点与核定域序列重叠。  |  Moroianu, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 6572-6. PMID: 8692858
  9. 核蛋白导入：Ran-GTP通过将α从β上的重叠结合位点移位，使核糖核蛋白α-β异二聚体解离。  |  Moroianu, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 7059-62. PMID: 8692944
  10. Epstein-Barr 病毒核抗原 1 与核转运体 karyopherin alpha2 形成复合物。  |  Fischer, N., et al. 1997. J Biol Chem. 272: 3999-4005. PMID: 9020106
  11. 克隆和鉴定人类 karyopherin beta3。  |  Yaseen, NR. and Blobel, G. 1997. Proc Natl Acad Sci U S A. 94: 4451-6. PMID: 9114010
  12. Karyopherin beta2 介导一种 mRNA 结合蛋白的核导入。  |  Bonifaci, N., et al. 1997. Proc Natl Acad Sci U S A. 94: 5055-60. PMID: 9144189

订购信息

产品名称产品编号规格价格数量收藏夹

karyopherin α1 抗体 (187.1)

sc-101292
100 µg/ml
$333.00

I need to use an antibody to detect the protein in samples of equine origin. Do you know if this mouse monoclonal antibody will work?

Asked by: jerojero
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Service 11
Date published: 2017-02-04
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Rated 4 out of 5 by from Ottimo funzionamento!L'anticorpo funziona bene, con una banda al peso indicato, tuttavia ci sono anche delle bande aspecifiche, nei lisati di A375.
Date published: 2023-09-13
Rated 5 out of 5 by from good productWe used 1:500 dilution in Hela cells and got strong and clear bands.
Date published: 2018-08-22
Rated 4 out of 5 by from Good for Western blotStrong clean band detected in HEK293T and HeLa cell lines following cleared whole cell lysate and immunoblotting. Better detection using RIPA vs 1% NP40/PBS.
Date published: 2017-12-07
Rated 5 out of 5 by from Good Function!I had to say, santa' antibody is very good! I use this antibody for WB at 1:1000.The band is clear and right in the weight! 293T cell lysis.
Date published: 2017-09-06
Rated 5 out of 5 by from Excellent antibodyA very well established clone that gives nice strong bands in Western blot and reliably gives clean and specific IHC staining. Smart choice!
Date published: 2017-01-17
Rated 5 out of 5 by from Clean band in western blot with HeLa wholeClean band in western blot with HeLa whole cell lysates. -SCBT QC
Date published: 2015-05-02
Rated 5 out of 5 by from Works great for western blot with tranfectedWorks great for western blot with tranfected lysates. -SCBT QC
Date published: 2015-04-20
Rated 4 out of 5 by from This antibody worked well on my blotThis antibody worked well on my blot.
Date published: 2015-03-24
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karyopherin α1 抗体 (187.1) is rated 4.7 out of 5 by 9.
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