KaempferolCAS: 520-18-3
MF: C15H10O6
MW: 286.24
An inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I.

Kaempferol (CAS 520-18-3)

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同义词: 3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; Robigenin
应用; An inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I
CAS号码: 520-18-3
纯度: ≥98%
分子量: 286.24
分子式: C15H10O6
* 参考分析证明 大量特定数据 (包括水 含量).
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Kaempferol is a naturally occurring flavonoid shown to act as a potent reversible inhibitor of Fatty Acid Synthase. Flavonoids have radical scavenging activity. Studies demonstrate that Kaempferol induces apoptosis in cancer cell lines and PC12 cell research reports Kaempferol to protect against oxidative stress-induced cytotoxicity. Additionally, Kaempferol has been shown to have a neuroprotective effect and represses the advancement of allergic inflammation mediated by IgE in difference cell models. A study which compared the CYP246 activity of Galangin (sc-235240), quercetin (sc-206089), and Kaempferol revealed that Kaempferol was the least potent flavanoid, with quercetin having the highest potency. Kaempferol acts as an inhibitor of Cox-1 activity (IC50 = 180 μM) and inhibits Topo I catalyzed DNA religation in HL-60 cells. Kaempferol is an inhibitor of MAO.


参考文献

1. Rice-Evans, C.A., et al. 1996. Free Radical Biol. Med. 20: 933-956. PMID: 8743980
2. Li, B.H., et al. 2003. J Enzyme Inhib Med Chem. 18: 349-356. PMID: 14567550
3. Lupu, R., et al. 2006. Curr Pharm Biotechnol. 7: 483-493. PMID: 17168665
4. Kim, J.K., et al. 2010. Biosci. Biotechnol. Biochem. 74: 397-401. PMID: 20139605
5. Lee, E.J., et al. 2010. Inflamm Res. 59: 847-854. PMID: 20383790
6. Tiong, K.H., et al. 2010. Xenobiotica. 40: 458-466. PMID: 20402563

外观 :
Powder
物理状态 :
Solid
溶解度 :
Soluble in ethanol (20 mg/ml), DMSA, DMSO (25 mg/ml), and methanol. Insoluble in water.
保存 :
Store at 4° C
熔点 :
276-278° C
沸点 :
~582.1° C at 760 mmHg (Predicted)
密度 :
~1.7 g/cm3 (Predicted)
折射率 :
n20D 1.79 (Predicted)
IC50 :
EGFR: IC50 = 10.48 µM (human); COX-2: IC50 = <15 µM; COX-1: IC50 = 180 µM; HL-60: IC50 = 34.94 µM (human); HeLa: IC50 = 8.39 µM (human)
Ki 数据 :
CYP1B1: Ki= 43 nM (human); CYP1A1: Ki= 750 nM (human); MRP1: Ki= 2.4 µM (human); BChE: Ki= 43.1 µM (human); CYP2C9: Ki= 6 µM (human)
pK值 :
pKa: 6.34 (Predicted)
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
LK9275200
PubChem CID :
5280863
默克索引 :
14: 5274
MDL 号码 :
MFCD00016938
EC号码 :
208-287-6
Beilstein 注册 :
304401
SMILES :
C1=CC(=CC=C1C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)O

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PMID: # 29122665  Ferreira, A. et al. 2017. Food Chem. Toxicol. 111: 84-93.

PMID: # 28603085  Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.

PMID: # 30261862  BMC Complement Altern Med. 18: 263.

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