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Islet-2 Antibody (A-1) is a high quality monoclonal Islet-2 antibody (also designated Islet-2 antibody) suitable for the detection of the Islet-2 protein of mouse, rat and human origin. Islet-2 Antibody (A-1) is available as both the non-conjugated anti-Islet-2 antibody form, as well as multiple conjugated forms of anti-Islet-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Islet-2 (insulin gene enhancer protein ISL-2) is a 359 amino acid protein encoded by the human gene ISL2. Islet-2 is a nuclear protein that contains two N-terminal LIM domains, followed by a homeodomain and a serine/ glutamine/threonine-rich C-terminus. Islet-2 is a transcriptional factor that defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axon pathways. Islet-1 and Islet-2 are initially expressed by all postmitotic spinal motor neurons prior to diversification of somatic and visceral neuronal fates. Somatic, but not visceral, motor neurons maintain Islet-2 expression at later embryonic stages. An early phase of Islet-2 expression by prospective visceral motor neurons of the sympathetic preganglionic motor column is critical for the emergence of complete visceral motor neuron character. Mutations that reduce or eliminate both Islet-1 and Islet-2 activity will result in pronounced defects in visceral motor neuron generation and eroded somatic motor neuron character.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
I need to use an antibody to detect the protein in samples of canine origin. Do you know if Islet-2 (A-1): sc-390746 mouse monoclonal antibody will work?
Asked by: jerojero
Thank you for your inquiry. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity. We are available by phone, e-mail or chat.
Rated 4 out of
faint staining but its thereThis antibody was generously given to me by the trials program. I found that it works for IHC at a dilution of 1:50 whole mount retinal tissue. Staining is somewhat faint. It works better in MetOH fixation than in PFA.
Date published: 2018-03-14
Rated 4 out of
It works!I used Islet-2 antibody to stain differentiated motor neurons. The antibody seems to work well, but I think I have very few positive cells. I will repeat the satin again with my next differentiation experiment and update this review with more images.
Date published: 2018-01-09
Rated 5 out of
Nice Western blot data of IsletNice Western blot data of Islet-2 expression in non-transfected and human Islet-2 transfected 293 whole cell lysates. -SCBT QC