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IQGAP3 Antibody (D-10) is a high quality monoclonal IQGAP3 antibody suitable for the detection of the IQGAP3 protein of mouse, rat and human origin. IQGAP3 Antibody (D-10) is available as both the non-conjugated anti-IQGAP3 antibody form, as well as multiple conjugated forms of anti-IQGAP3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson′s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Rated 1 out of
TerribleUsed 100 ug of tissue on a western blot and could barely detect anything. Probed for GAPDH on this same membrane and it was fine so I know it wasn't the blot.
Date published: 2018-02-21
Rated 1 out of
detect only IQ2overexpressed GFP-IQ1, 2, 3 in 293 cells. the Ab could detect only IQ2 weakly. there is weak non-specific band on 100kD.
1/1000 dil in 2% BSA TBST, o/n reaction.
Date published: 2017-03-23
Rated 5 out of
Very good Western blot data of IQGAP3 expressionVery good Western blot data of IQGAP3 expression in Hep G2 whole cell lysate and human placenta tissue extract . -SCBT QC