Date published: 2025-9-7

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Inhibin α 抗体 (D-4): sc-365439

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说明书
  • Inhibin alpha 抗体 D-4 是小鼠单克隆 IgG1 κ,Inhibin α抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列233-366位于human物种的Inhibin α的C-terminus
  • Inhibin alpha 抗体 (D-4) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 precursor and mature chain of Inhibin α
  • 抗Inhibin alpha抗体(D-4)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Inhibin α (D-4): sc-365439免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Inhibin α Antibody (D-4) for WB applications. 的首选辅助检测试剂,这些试剂现与Inhibin α Antibody (D-4) 打包提供(请参阅下面的订购信息)。

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関連項目

抑制素α抗体(D-4)是一种IgG1 κ小鼠单克隆抑制素α抗体(也称为抑制素α抗体),可通过WB、IP、IF和ELISA检测人源抑制素α蛋白。抑制素α抗体(D-4)既有非偶联的抗抑制素α抗体形式,也有多种偶联形式的抗抑制素α抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。抑制素是一种性腺蛋白,优先抑制垂体促卵泡激素(FSH)的分泌。抑制素由两个亚基组成,抑制素A和抑制素B。每个亚基由相同的α亚基与两个不同的亚基β-α或β-β共价连接而成。抑制素最初是从卵巢卵泡液中分离出来的,其特征是二硫键连接的二聚体糖蛋白,属于转化生长因子β(TGFβ)生长和分化因子超家族。TGFβ蛋白除了在生殖方面的作用外,还影响多种组织和系统。除了在生殖系统内分泌反馈中的作用外,抑制素还在许多性腺外组织中发挥局部调节作用,包括大脑、肾上腺、骨髓、胎盘,尤其是前垂体。抑制素α亚基基因表达在人前列腺癌中被下调,提示其具有抑瘤作用。人类抑制素α基因定位于2q33-q36染色体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Inhibin α 抗体 (D-4) 参考文献:

  1. 激活蛋白在男性生殖道中的作用。  |  Risbridger, GP. and Cancilla, B. 2000. Rev Reprod. 5: 99-104. PMID: 10864854
  2. 前列腺癌中抑制素α亚基基因的高甲基化。  |  Schmitt, JF., et al. 2002. Mol Endocrinol. 16: 213-20. PMID: 11818495
  3. 实体假乳头状瘤表达抑制素-α和Tcf-3。  |  Shirai Et Al,., et al. 2017. Pathol Int. 67: 228-229. PMID: 28213917
  4. 接种抑制素-α疫苗可提供针对睾丸间质细胞肿瘤的有效免疫疗法。  |  Aguilar, R., et al. 2017. J Immunother Cancer. 5: 37. PMID: 28428886
  5. 来自猪卵巢和人类胎盘的抑制素 A 亚基 cDNAs。  |  Mayo, KE., et al. 1986. Proc Natl Acad Sci U S A. 83: 5849-53. PMID: 3016724
  6. 卵巢透明细胞癌细胞中未成熟的抑制素α亚群与不良预后有关。  |  Kusumoto, S., et al. 2021. Cancer Med. 10: 1485-1500. PMID: 33611864
  7. 人类黑色素瘤细胞中抑制素α基因的甲基化和突变以及去甲基化剂对PTEN表达和AKT/PI3K信号传导的调节。  |  Ko, H., et al. 2022. Oncol Rep. 47: PMID: 34958114
  8. NR5A1/SF-1与抑制素α和雄激素受体协同作用。  |  Naamneh Elzenaty, R., et al. 2024. Int J Mol Sci. 25: PMID: 39337600
  9. 立体定向放射外科治疗耳内声波肿瘤后的颅神经保留。  |  Ogunrinde, OK., et al. 1995. Stereotact Funct Neurosurg. 64 Suppl 1: 87-97. PMID: 8584844
  10. 抑制素, 活化素和绒毛素在女性生殖系统中的作用。  |  Knight, PG. 1996. Front Neuroendocrinol. 17: 476-509. PMID: 8905350
  11. Activins, inhibins 和 follistatins:对不断壮大的调节因子家族的进一步思考。  |  Mather, JP., et al. 1997. Proc Soc Exp Biol Med. 215: 209-22. PMID: 9207855
  12. 高等级前列腺癌中抑制素α亚基的表达和定位缺失。  |  Mellor, SL., et al. 1998. J Clin Endocrinol Metab. 83: 969-75. PMID: 9506758

订购信息

产品名称产品编号规格价格数量收藏夹

Inhibin α 抗体 (D-4)

sc-365439
200 µg/ml
$316.00

Inhibin α (D-4): m-IgG Fc BP-HRP 套装

sc-527367
200 µg Ab; 10 µg BP
$354.00

Inhibin α (D-4): m-IgG1 BP-HRP 套装

sc-532740
200 µg Ab; 20 µg BP
$354.00

Inhibin α 抗体 (D-4) AC

sc-365439 AC
500 µg/ml, 25% agarose
$416.00

Inhibin α 抗体 (D-4) HRP

sc-365439 HRP
200 µg/ml
$316.00

Inhibin α 抗体 (D-4) FITC

sc-365439 FITC
200 µg/ml
$330.00

Inhibin α 抗体 (D-4) PE

sc-365439 PE
200 µg/ml
$343.00

Inhibin α 抗体 (D-4) Alexa Fluor® 488

sc-365439 AF488
200 µg/ml
$357.00

Inhibin α 抗体 (D-4) Alexa Fluor® 546

sc-365439 AF546
200 µg/ml
$357.00

Inhibin α 抗体 (D-4) Alexa Fluor® 594

sc-365439 AF594
200 µg/ml
$357.00

Inhibin α 抗体 (D-4) Alexa Fluor® 647

sc-365439 AF647
200 µg/ml
$357.00

Inhibin α 抗体 (D-4) Alexa Fluor® 680

sc-365439 AF680
200 µg/ml
$357.00

Inhibin α 抗体 (D-4) Alexa Fluor® 790

sc-365439 AF790
200 µg/ml
$357.00

In your product citations it states that this antibody was used on FFPE tissue for IHC staining, there is only information on antigen retrieval and nothing on concentration used. What is the recommended dilution for IHC-P?

Asked by: Frazer
Thank you for your question. We recommend a starting dilution of 1:50-1:500.
Answered by: BlakeJ
Date published: 2023-03-16

What is the recommended fixation method for immunofluorescence staining with Inhibin α (D-4): sc-365439 monoclonal antibody?

Asked by: Germaine
Thank you for your inquiry. We recommend fixing cells for 5 minutes in -10°C methanol and allowing to air dry. The full protocol can be viewed here: https://www.scbt.com/scbt/resources/protocols/immunofluorescence-cell-staining
Answered by: Technical Support
Date published: 2017-02-27
  • y_2025, m_8, d_30, h_9CST
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Rated 4 out of 5 by from Buon funzionamento anche in IHCSegnale specifico e di buona intensità su campioni FFPE di ovaio di cavallo e cane.
Date published: 2023-10-24
Rated 1 out of 5 by from NO SIGNALa-Inhibin α (D-4) sc-365439 47kDa M-IgGk BP-HRP sc-516102 1:1000 NO SIGNAL
Date published: 2017-08-01
Rated 4 out of 5 by from Works well for biological assaysWe tried this for our tube formation assays and it worked well!
Date published: 2016-12-01
Rated 5 out of 5 by from Produced excellent immunofluorescence cytoplasmicProduced excellent immunofluorescence cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-25
Rated 5 out of 5 by from Produced positive Western Blot data of InhibinProduced positive Western Blot data of Inhibin expression in non-transfected and human Inhibin transfected CHO whole cell lysates. -SCBT QC
Date published: 2013-10-27
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Inhibin α 抗体 (D-4) is rated 3.8 out of 5 by 5.
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