Date published: 2025-9-7

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IL-8RB 抗体 (E-2): sc-7304

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说明书
  • IL-8RB抗体(E-2)是小鼠单克隆IgG2a λ IL-8RB抗体, 在29篇文献中引用,规格为200 µg/ml
  • 免疫human来源IL-8RB位于N-terminus 的1-19氨基酸
  • IL-8RB 抗体 (E-2) 推荐用于WB, IP, IF, IHC(P) 和 FCM,检测human 来源的 IL-8RB
  • 抗IL-8RB抗体(E-2)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IL-8RB (E-2): sc-7304免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 IL-8RB 抗体 (E-2) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与IL-8RB 抗体 (E-2) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

IL-8RB抗体(E-2)是一种小鼠单克隆IgG2a抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)检测人源IL-8RB蛋白。IL-8RB 单克隆抗体(E-2)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种 Alexa Fluor® 结合物。IL-8RB蛋白(也称为C-X-C基序趋化因子受体2)在介导炎症反应中起着至关重要的作用,它充当白细胞介素8(IL-8)的受体,而IL-8是一种对中性粒细胞有强烈趋化作用的因子。这种受体主要表达于中性粒细胞,在单核细胞和某些髓细胞系中表达水平较低,这凸显了其在免疫反应和炎症中的重要性。值得注意的是,IL-8RB是七跨膜结构域视紫红质超家族受体的一部分,该家族受体对于G蛋白偶联信号转导至关重要。IL-8RB与IL-8相互作用不仅促进中性粒细胞趋化,还增强其活性,使IL-8RB成为各种炎症疾病病理生理学的关键因素。了解IL-8RB及其信号传导途径的动态变化,有助于为过度炎症病症的治疗提供新的靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-8RB 抗体 (E-2) 参考文献:

  1. 人类细胞因子基因核苷酸序列排列:白细胞介素 4 受体α链(IL4RA)、IL5RA、IL8、IL8RB 和 IL13。  |  Laundy, GJ. and Bidwell, JL. 2003. Eur J Immunogenet. 30: 13-87. PMID: 12558816
  2. 白细胞介素-8 是血管生成的巨噬细胞衍生介质。  |  Koch, AE., et al. 1992. Science. 258: 1798-801. PMID: 1281554
  3. 两种高亲和力人类白细胞介素-8受体的特征。  |  Lee, J., et al. 1992. J Biol Chem. 267: 16283-7. PMID: 1379593
  4. 白细胞介素 8 及相关细胞因子对人中性粒细胞质膜中 G 蛋白的激活作用  |  Kupper, RW., et al. 1992. Biochem J. 282 (Pt 2): 429-34. PMID: 1546956
  5. 人类白细胞介素-8 受体的结构和功能表达。  |  Holmes, WE., et al. 1991. Science. 253: 1278-80. PMID: 1840701
  6. 克隆编码功能性人白细胞介素-8 受体的互补 DNA。  |  Murphy, PM. and Tiffany, HL. 1991. Science. 253: 1280-3. PMID: 1891716
  7. 阻断 C-X-C Motif 趋化因子受体 2 (CXCR2) 可抑制尿酸 (UA) 诱导的心脏重构  |  Xu, M., et al. 2021. Front Physiol. 12: 700338. PMID: 34385934
  8. 通过抑制 C-X-C Motif 趋化因子受体 2 预防化疗引起的周围神经病变  |  Cho, HS., et al. 2023. Int J Mol Sci. 24: PMID: 36768178
  9. 单克隆抗体检测人体外周血白细胞中 IL-8 受体 A 和 IL-8 受体 B 的不同分布模式。  |  Chuntharapai, A., et al. 1994. J Immunol. 153: 5682-8. PMID: 7527448
  10. 白细胞介素-8:综述。  |  Hébert, CA. and Baker, JB. 1993. Cancer Invest. 11: 743-50. PMID: 8221207
  11. 人中性粒细胞膜上白细胞介素-8受体的特征:鸟嘌呤核苷酸的调控。  |  Barnett, ML., et al. 1993. Biochim Biophys Acta. 1177: 275-82. PMID: 8323978
  12. 人类吞噬细胞, 淋巴细胞和黑色素瘤细胞中两种白细胞介素 8 受体转录本的表达。  |  Moser, B., et al. 1993. Biochem J. 294 (Pt 1): 285-92. PMID: 8363581

订购信息

产品名称产品编号规格价格数量收藏夹

IL-8RB 抗体 (E-2)

sc-7304
200 µg/ml
$316.00

IL-8RB (E-2): m-IgG Fc BP-HRP 套装

sc-525437
200 µg Ab; 10 µg BP
$354.00

IL-8RB 抗体 (E-2) AC

sc-7304 AC
500 µg/ml, 25% agarose
$416.00

IL-8RB 抗体 (E-2) HRP

sc-7304 HRP
200 µg/ml
$316.00

IL-8RB 抗体 (E-2) FITC

sc-7304 FITC
200 µg/ml
$330.00

IL-8RB 抗体 (E-2) PE

sc-7304 PE
200 µg/ml
$343.00

IL-8RB 抗体 (E-2) Alexa Fluor® 488

sc-7304 AF488
200 µg/ml
$357.00

IL-8RB 抗体 (E-2) Alexa Fluor® 546

sc-7304 AF546
200 µg/ml
$357.00

IL-8RB 抗体 (E-2) Alexa Fluor® 594

sc-7304 AF594
200 µg/ml
$357.00

IL-8RB 抗体 (E-2) Alexa Fluor® 647

sc-7304 AF647
200 µg/ml
$357.00

IL-8RB 抗体 (E-2) Alexa Fluor® 680

sc-7304 AF680
200 µg/ml
$357.00

IL-8RB 抗体 (E-2) Alexa Fluor® 790

sc-7304 AF790
200 µg/ml
$357.00

What negative control should be used when using the conjugated version of IL-8RB (E-2): sc-7304 monoclonal antibody in flow cytometry?

Asked by: sweetums
Thank you for your inquiry. We recommend using the isotype specific normal mouse IgG conjugated to the same fluorophore. For example, if you are using sc-7304 PE, then you would want to use normal mouse IgG1 PE, sc-2866.
Answered by: Technical Support 5
Date published: 2017-01-22
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Rated 3 out of 5 by from IL8-RB For WB1:1000 diluted in MCF7 used for WB, there are one specific band and some nonspecific bands too.
Date published: 2018-04-12
Rated 4 out of 5 by from it can not be used for pig tissueThis product can be used for immunohistochemistry of human tissue, can not be used for pig tissue, the positive signal in cytoplasm.
Date published: 2017-09-09
Rated 3 out of 5 by from western blottingWestern blotting :1:200 , no band ,I can't found the reason.
Date published: 2017-04-11
Rated 5 out of 5 by from Excellent choice for IL-8RBStrong antibody for IL-8RB. Works great in IF, IHC, WB and in Flow cytometry, so it's a wise choice for all your IL-8RB detection needs.
Date published: 2017-01-12
Rated 1 out of 5 by from Saw many nonSaw many non-specifics in WB.
Date published: 2015-07-31
Rated 5 out of 5 by from Published data for IP and WB in human epithelialPublished data for IP and WB in human epithelial cells. -SCBT Publication Review
Date published: 2015-06-30
Rated 5 out of 5 by from Published data for WB in mouse mammary carcinomaPublished data for WB in mouse mammary carcinoma cell lines. -SCBT Publication Review
Date published: 2015-04-25
Rated 5 out of 5 by from Strong band of interest detected in WB in CHOStrong band of interest detected in WB in CHO-K1 cells transfected with IL-8RB. -SCBT QC
Date published: 2015-04-16
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IL-8RB 抗体 (E-2) is rated 4.3 out of 5 by 13.
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