Date published: 2025-9-7
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IL-13Rα2 抗体 (B-D13): sc-57267

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说明书
  • IL-13R alpha 2 抗体 B-D13 是小鼠单克隆 IgG1, 在8篇文献中引用，提供 100 µg/ml
  • 免疫human物种的IL-13Rα2
  • 推荐用于 human 来源的IL-13Rα2 IF, IHC(P) 和 FCM检测
  • 目前，我们还没有完成IL-13Rα2 抗体 (B-D13)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 IL-2/IL-4/IL-7/IL-9/IL-13/IL-15 Receptor Complex 抗体包括 IL-13R α 1, IL-13R α 2, IL-15R α, IL-2R, IL-2R α, IL-2R β, IL-2R γ, IL-4R α, IL-7R 和 IL-9R

IL-13Rα2 抗体 (B-D13) 是一种小鼠单克隆 IgG1 抗体，可通过免疫荧光 (IF)、石蜡包埋切片免疫组化 (IHCP) 和流式细胞术 (FCM) 等应用检测人体样本中的 IL-13Rα2。IL-13Rα2在调节白细胞介素-13效应方面发挥着重要作用，而白细胞介素-13是一种参与过敏反应和哮喘的关键细胞因子。IL-13Rα1 可促进导致炎症的信号通路，而 IL-13Rα2 则不同，它主要作为诱饵受体发挥作用，与 IL-13 结合而不启动信号级联。这种独特的特性为 IL-13 信号传导提供了一种负反馈机制，有助于调节免疫反应和防止过度炎症。IL-13Rα2 在胶质瘤细胞中的表达尤为突出，这表明它在肿瘤生物学和针对 IL-13 通路的治疗策略开发中具有潜在作用。抗 IL-13Rα2 抗体 (B-D13) 使研究人员能够深入了解 IL-13 信号传导动态及其在过敏性疾病和癌症等各种疾病中的影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-13Rα2 抗体 (B-D13) 参考文献:

  1. IL-13Ralpha2 受体在胃肠道纤维化发展和癌症监控中的信号功能。  |  Strober, W., et al. 2009. Curr Mol Med. 9: 740-50. PMID: 19689301
  2. IL-13抗体通过调节IL-13Rα2的清道夫活性影响人体对IL-13的清除。  |  Kasaian, MT., et al. 2011. J Immunol. 187: 561-9. PMID: 21622864
  3. TNF-α/IL-17协同作用通过诱导IL-13Rα2抑制IL-13的生物活性。  |  Badalyan, V., et al. 2014. J Allergy Clin Immunol. 134: 975-8.e5. PMID: 24954262
  4. IL-13Rα2是人类胰腺癌诊断和治疗反应的生物标记物  |  Fujisawa, T., et al. 2021. Diagnostics (Basel). 11: PMID: 34201539
  5. IL-13Rα2 引导的癌症免疫疗法的最新进展。  |  Knudson, KM., et al. 2022. Front Immunol. 13: 878365. PMID: 35464460
  6. 以表皮生长因子受体vIII和IL-13Rα2为靶细胞的串联嵌合抗原受体（CAR）T细胞对异质性胶质母细胞瘤有效。  |  Schmidts, A., et al. 2023. Neurooncol Adv. 5: vdac185. PMID: 36751672
  7. 曲洛金单抗可有效破坏IL-13/IL-13Rα1/IL-4Rα信号复合物，但不会破坏IL-13/IL-13Rα2复合物。  |  Tollenaere, MAX., et al. 2023. JID Innov. 3: 100214. PMID: 37554517
  8. IL-13Rα2靶向CAR-T细胞局部递送治疗复发性高级别胶质瘤：1期试验。  |  Brown, CE., et al. 2024. Nat Med. 30: 1001-1012. PMID: 38454126
  9. 作者更正：IL-13Rα2靶向CAR-T细胞局部递送治疗复发性高级别胶质瘤：1期试验。  |  Brown, CE., et al. 2024. Nat Med. 30: 1501. PMID: 38514871
  10. IL-13Rα2/TGF-β 双特异性 CAR-T 细胞可对抗 TGF-β 介导的免疫抑制，并增强胶质母细胞瘤的抗肿瘤反应。  |  Hou, AJ., et al. 2024. Neuro Oncol. 26: 1850-1866. PMID: 38982561

订购信息

产品名称产品编号规格价格数量收藏夹

IL-13Rα2 抗体 (B-D13)

sc-57267
100 µg/ml
$316.00

Which domain of the protein is the structure of sc-57267: IL-13Rα2 (B-D13) monoclonal antibody recognized as the antigen?

Asked by: Akihiro148
Thank you for your question. No epitope mapping has been performed for this antibody yet, so we cannot say which domain of its target protein it recognizes.
Answered by: Tech Support Europe
Date published: 2020-09-29

Can sc-57267: IL-13Rα2 (B-D13) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Germaine
Thank you for your question. Yes, sc-57267: IL-13Rα2 (B-D13) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Strong Signal, Diverse UsesThis antibody is well-cited for a variety of applications including IF and even IHC. Strong, clear signal with little to no background. Beautiful tissue staining.
Date published: 2017-02-09
Rated 5 out of 5 by from Antibody was used to gather published dataAntibody was used to gather published data in FCM with HeLa, HUT102, Raji, FaDu, and SW579 cell lines
Date published: 2015-04-14
Rated 5 out of 5 by from Positive Flow Cytometry data gathered withPositive Flow Cytometry data gathered with numerous human cell lines tumor lesions and peripheral blood mononuclear cells -SCBT Publication Review
Date published: 2015-01-04
Rated 5 out of 5 by from Produced publishable IF data with human melanomaProduced publishable IF data with human melanoma cell lines - SCBT Publication Review
Date published: 2013-09-03
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IL-13Rα2 抗体 (B-D13) is rated 5.0 out of 5 by 4.
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