Date published: 2025-9-7

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IL-11 抗体 (A-9): sc-133063

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说明书
  • IL-11 抗体 A-9 是小鼠单克隆 IgG2a κ,IL-11抗体, 在6篇文献中引用,规格为200 µg/ml
  • 免疫human物种的IL-11的氨基酸31-199
  • IL-11 抗体 (A-9) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 IL-11
  • 抗IL-11抗体(A-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取IL-11 (A-9): sc-133063免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是IL-11 Antibody (A-9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与IL-11 Antibody (A-9) 打包提供(请参阅下面的订购信息)。

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関連項目

IL-11抗体(A-9)是一种IgG2a κ型小鼠单克隆IL-11抗体(也称为IL11抗体、脂肪生成抑制因子抗体、Oprelvekin抗体、IL-11抗体、AGIF抗体或白细胞介素-11抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类来源的IL-11蛋白。IL-11抗体(A-9)既可以是非偶联的抗IL-11抗体形式,也可以是多种偶联形式的抗IL-11抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。白细胞介素-11(IL-11)是一种多效性细胞因子,与IL-6、白血病抑制因子(LIF)、抑瘤素M(OSM)和睫状神经营养因子(CNTF)在生物学上具有相关性。IL-11是一种基质细胞来源的细胞因子,可刺激原始造血祖细胞的增殖,并与Flt 3-L一起刺激CD34+细胞群的扩张。人类IL-11的cDNA编码一个199个氨基酸的前体,其中包含一个21个氨基酸的疏水信号肽,该信号肽被切割后生成一种糖基化的生物活性形式。IL-11通过白细胞介素-11受体(IL-11R)发挥其生物学效应,IL-11R由特定的IL-11受体链(称为IL-11Rα)和gp130组成,后者是IL-6、LIF、OSM和CNTF受体共有的信号转导成分。IL-11R的刺激导致Janus酪氨酸激酶家族成员JAK1和JAK2的激活,一旦激活,它们会诱导转录因子Stat1和Stat3的核转位。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

IL-11 抗体 (A-9) 参考文献:

  1. 编码白细胞介素 11(一种从基质细胞衍生的淋巴造血和造血细胞因子)的 cDNA 的分子克隆。  |  Paul, SR., et al. 1990. Proc Natl Acad Sci U S A. 87: 7512-6. PMID: 2145578
  2. 重组人白细胞介素-11(IL-11)是严重败血症伴血小板减少症的保护因子:病例对照研究。  |  Wan, B., et al. 2015. Cytokine. 76: 138-143. PMID: 26276375
  3. 白细胞介素-11 和白细胞介素-6 生物学的蛋白水解控制。  |  Lokau, J., et al. 2017. Biochim Biophys Acta Mol Cell Res. 1864: 2105-2117. PMID: 28630024
  4. 白细胞介素-11 信号是气道纤维化、实质功能障碍和慢性炎症的基础。  |  Ng, B., et al. 2020. Exp Mol Med. 52: 1871-1878. PMID: 33262481
  5. IL-11 在调节骨代谢中的作用。  |  Han, Y., et al. 2023. Front Endocrinol (Lausanne). 14: 1290130. PMID: 38352248
  6. 白细胞介素 11 治疗会导致急性左心室功能障碍。  |  Sweeney, M., et al. 2024. Cardiovasc Res. 120: 2220-2235. PMID: 39383190
  7. 白细胞介素-6 家族细胞因子信号转导因子 gp130 对 Fes 酪氨酸激酶的激活及其缔合作用。  |  Matsuda, T., et al. 1995. J Biol Chem. 270: 11037-9. PMID: 7538109
  8. 白细胞介素(IL)-11介导的信号转导。  |  Yang, YC. and Yin, T. 1995. Ann N Y Acad Sci. 762: 31-40; discussion 40-1. PMID: 7545369
  9. IL-11 与 SLF, G-CSF 或 GM-CSF 联合使用,可显著增加脐带血与成人骨髓中分离出的 CD34+ 细胞群的扩增。  |  van de Ven, C., et al. 1995. Exp Hematol. 23: 1289-95. PMID: 7589284
  10. 利用 gp130 和相关转导因子的细胞因子激活 STAT3 需要 H7 敏感激酶进行二次修饰。  |  Boulton, TG., et al. 1995. Proc Natl Acad Sci U S A. 92: 6915-9. PMID: 7624343
  11. 白细胞介素-11(IL-11)是人类髓性白血病细胞增殖的协同因子。  |  Lemoli, RM., et al. 1995. Br J Haematol. 91: 319-26. PMID: 8547068
  12. 在骨髓基质/成骨细胞中检测白细胞介素-6, 白细胞介素-11, 白血病抑制因子, 鹅肌肽 M 和睫状神经营养因子的受体。  |  Bellido, T., et al. 1996. J Clin Invest. 97: 431-7. PMID: 8567964

订购信息

产品名称产品编号规格价格数量收藏夹

IL-11 抗体 (A-9)

sc-133063
200 µg/ml
$316.00

IL-11 (A-9): m-IgG Fc BP-HRP 套装

sc-525743
200 µg Ab; 10 µg BP
$354.00

IL-11 (A-9): m-IgG2a BP-HRP 套装

sc-546392
200 µg Ab; 10 µg BP
$354.00

IL-11 抗体 (A-9) AC

sc-133063 AC
500 µg/ml, 25% agarose
$416.00

IL-11 抗体 (A-9) HRP

sc-133063 HRP
200 µg/ml
$316.00

IL-11 抗体 (A-9) FITC

sc-133063 FITC
200 µg/ml
$330.00

IL-11 抗体 (A-9) PE

sc-133063 PE
200 µg/ml
$343.00

IL-11 抗体 (A-9) Alexa Fluor® 488

sc-133063 AF488
200 µg/ml
$357.00

IL-11 抗体 (A-9) Alexa Fluor® 546

sc-133063 AF546
200 µg/ml
$357.00

IL-11 抗体 (A-9) Alexa Fluor® 594

sc-133063 AF594
200 µg/ml
$357.00

IL-11 抗体 (A-9) Alexa Fluor® 647

sc-133063 AF647
200 µg/ml
$357.00

IL-11 抗体 (A-9) Alexa Fluor® 680

sc-133063 AF680
200 µg/ml
$357.00

IL-11 抗体 (A-9) Alexa Fluor® 790

sc-133063 AF790
200 µg/ml
$357.00

Is this compatible with Flow Cytometry by indirect detection?

Asked by: ELEE
Thank you for your question. We do not recommend using the unconjugated antibody for flow cytometry because we have not tested the antibody yet in this application.
Answered by: Technical Support
Date published: 2017-11-15

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with IL-11 (A-9): sc-133063?

Asked by: cjMara
We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-02-27
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Rated 3 out of 5 by from No stripeThis might be blamed to the mishandling of WB that all the PVDF membranes were nothing on it. But the free sample was run out, It was difficult to verify the validity of this antibody.
Date published: 2018-06-14
Rated 4 out of 5 by from Nice band seen in WB using human recombinant ILNice band seen in WB using human recombinant IL-11. -SCBT QC
Date published: 2015-05-30
Rated 4 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB. -SCBT QC
Date published: 2015-05-16
Rated 5 out of 5 by from ELISA publishable data with mouse MC3T3ELISA publishable data with mouse MC3T3-E1 cells - SCBT Publication Review
Date published: 2014-09-28
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IL-11 抗体 (A-9) is rated 4.0 out of 5 by 4.
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