Date published: 2025-10-5

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IGF-1 Receptor/IGF1R 抗体 (3B7): sc-462

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说明书
  • IGF-1 Receptor/IGF1R 抗体 3B7 是小鼠单克隆 IgG1 κ,IGF-1 Receptor/IGF1R抗体, 在38篇文献中引用,规格为200 µg/ml
  • 针对从human胎盘中纯化的IGF-I受体的
  • IGF-1 Receptor/IGF1R 抗体 (3B7) 推荐用于 IP 和 FCM,检测mouse, rat 和human 来源的 IGF-I
  • 抗IGF-1 Receptor/IGF1R抗体(3B7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 还提供无叠氮化物,用于生物学研究,sc-462 L,200 µg/0.1 ml
  • 目前,我们还没有完成IGF-1 Receptor/IGF1R 抗体 (3B7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

快捷链接

関連項目

IGF-IR抗体(3B7)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过免疫沉淀(IP)和流式细胞术(FCM)检测小鼠、大鼠和人类来源的IGF-IR蛋白。IGF-IR单克隆抗体(3B7)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。胰岛素样生长因子-I受体(IGF-IR)在细胞信号传导中起着至关重要的作用,它作为一种受体酪氨酸激酶,可调节细胞生长、存活和分化等基本过程。IGF-IR位于细胞膜上,由其配体胰岛素样生长因子-I(IGF-I)激活,从而招募信号蛋白(如Shc、GRB2和Sos 1),启动Ras和ERK激酶通路。这些途径对于调节转录因子的活性至关重要,包括激活Elk转录因子,后者对于与生长和发育相关的基因表达非常重要。此外,胰岛素受体底物(IRS)-1和-2蛋白含有磷酪氨酸结合结构域,与活性IGF-IR相互作用,触发磷脂酰肌醇3激酶依赖性信号级联反应,进一步影响细胞反应。人类IGF-IR基因位于15q26.3染色体上,编码一种1376个氨基酸的前体蛋白,该蛋白被切割成α和β亚基,这凸显了该受体在各种生物过程中的复杂性和重要性,以及其在癌症生物学中的潜在意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

订购信息

产品名称产品编号规格价格数量收藏夹

IGF-1 Receptor/IGF1R 抗体 (3B7)

sc-462
200 µg/ml
$316.00

IGF-1 Receptor/IGF1R 抗体 (3B7) L

sc-462 L
200 µg/0.1 ml
$316.00

IGF-1 Receptor/IGF1R 抗体 (3B7) AC

sc-462 AC
500 µg/ml, 25% agarose
$416.00

IGF-1 Receptor/IGF1R 抗体 (3B7) HRP

sc-462 HRP
200 µg/ml
$316.00

IGF-1 Receptor/IGF1R 抗体 (3B7) FITC

sc-462 FITC
200 µg/ml
$330.00

IGF-1 Receptor/IGF1R 抗体 (3B7) PE

sc-462 PE
200 µg/ml
$343.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 488

sc-462 AF488
200 µg/ml
$357.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 546

sc-462 AF546
200 µg/ml
$357.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 594

sc-462 AF594
200 µg/ml
$357.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 647

sc-462 AF647
200 µg/ml
$357.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 680

sc-462 AF680
200 µg/ml
$357.00

IGF-1 Receptor/IGF1R 抗体 (3B7) Alexa Fluor® 790

sc-462 AF790
200 µg/ml
$357.00

Do you know if this antibody would react with equine tissue (IHC-P)?

Asked by: Marine
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

Can IGF-IR (3B7): sc-462 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: AbPolly
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, IGF-IR (3B7): sc-462 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Conjugates recommendedThe fluorescent conjugates of this antibody work particularly well in Flow Cytometry.
Date published: 2017-01-24
Rated 2 out of 5 by from Good AntibodyNice antibody working well in WB in breast cancer cell lines.
Date published: 2016-11-08
Rated 5 out of 5 by from Publishable data for Flow cytometry in humanPublishable data for Flow cytometry in human and mouse Ishikawa endometrial cancer cells and NIH/3T3 cells. -SCBT Publication Review
Date published: 2015-02-27
Rated 5 out of 5 by from Published data for WB and ELISA for use inPublished data for WB and ELISA for use in human vascular smooth muscle cells. -SCBT Publication Review
Date published: 2015-01-30
Rated 5 out of 5 by from Published data for WB in mouse 3T3Published data for WB in mouse 3T3-L1 cells. -SCBT Publication Review
Date published: 2015-01-06
Rated 5 out of 5 by from Published data for IP in human MCFPublished data for IP in human MCF-7 cells. -SCBT Publication Review
Date published: 2015-01-04
Rated 5 out of 5 by from Produced excellent FCM data for HeLa cellsProduced excellent FCM data for HeLa cells. -SCBT QC
Date published: 2013-03-10
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IGF-1 Receptor/IGF1R 抗体 (3B7) is rated 4.6 out of 5 by 7.
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