Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Insulin degrading enzyme (IDE), initiates the cleavage of insulin, resulting in insulin response and resistance. However, IDE also degrades a variety of bioactive peptides, including amyloid-β peptides, implicating IDE in certain age-related changes seen in Alzheimer′s disease. Studies show that when the expression of the IDE gene (chromosome 10q23.3) is altered, changes occur not only in glucose homeostasis, but also in the levels of brain Abeta40 and Abeta42 peptides. An IDE inhibitor, bacitracin, inhibits degradation of both insulin and amylin, indicating that both are degraded through a common proteolytic pathway. Variations in the rate of proteolysis suggest that the function of IDE exhibits conformational dependence, which may lead to possible therapeutic interventions for diabetes, AD, and other diseases associated with IDE substrate proteolysis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.