Name: Homer-3抗体 (G-2)
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<div class="ov-grid"><p>Homer家族蛋白，又称Vesl（癫痫发作期间会上调VASP/Ena相关基因）和LTP，它是即刻早期基因产物，与1组代谢型谷氨酸受体（mGluRs）结合，参与触发细胞内钙释放。与Homer家族原型成员Homer-1a不同，其他成员（Homer-1b 和 -1c, Homer-2a, -2b 和 -2c，Homer-3）组成性表达，并含有卷曲螺旋（CC）结构域，该结构域能介导自身多聚化。 Homer-1a 富集在兴奋性突触中，不发生多聚化，这阻断了mGluRs 与 CC-Homer 蛋白相结合。Homer蛋白能将 mGluRs 与三磷酸肌醇受体（IP3R）相连。</p><p><div class="left-padding"><span class="warning-bold">仅限研究使用。<span class="warning-color">不适用于诊断和治疗用途。</span></span></div></p><p>Alexa Fluor<sup>&reg;</sup> 是Molecular Probes Inc., OR., USA的商标</p><p>LI-COR<sup>&reg;</sup>和 Odyssey<sup>&reg;</sup> 是LI-COR Biosciences的注册商标</p><p><h2>Homer-3 抗体 (G-2) 参考文献:</h2><ol><li><a href="https://pubmed.ncbi.nlm.nih.gov/16098226/#&amp;dopt=Abstract" target="_blank" rel="nofollow">筛选与PAX6相互作用的蛋白质：C端突变会破坏与HOMER3、DNCL1和TRIM11的相互作用。</a>&nbsp; | &nbsp;Cooper, ST. and Hanson, IM. 2005. BMC Genet. 6: 43. PMID: 16098226</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/17224583/#&amp;dopt=Abstract" target="_blank" rel="nofollow">亚急性特发性小脑共济失调中的Homer 3自身免疫。</a>&nbsp; | &nbsp;Zuliani, L., et al. 2007. Neurology. 68: 239-40. PMID: 17224583</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/23725168/#&amp;dopt=Abstract" target="_blank" rel="nofollow">Homer3对白血病细胞系生长和分化产生的影响。</a>&nbsp; | &nbsp;Li, Z., et al. 2013. Asian Pac J Cancer Prev. 14: 2525-8. PMID: 23725168</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/25589726/#&amp;dopt=Abstract" target="_blank" rel="nofollow">淀粉样蛋白和&beta;蛋白前体与Homer3相互作用的结构和调节元素。</a>&nbsp; | &nbsp;Kyratzi, E., et al. 2015. J Alzheimers Dis. 45: 147-57. PMID: 25589726</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/25739453/#&amp;dopt=Abstract" target="_blank" rel="nofollow">Homer3调节中性粒细胞极性的建立。</a>&nbsp; | &nbsp;Wu, J., et al. 2015. Mol Biol Cell. 26: 1629-39. PMID: 25739453</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/26748090/#&amp;dopt=Abstract" target="_blank" rel="nofollow">Homer-3依赖性mTORC1表达受损影响SCA1病理生理学。</a>&nbsp; | &nbsp;Ruegsegger, C., et al. 2016. Neuron. 89: 129-46. PMID: 26748090</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/34108014/#&amp;dopt=Abstract" target="_blank" rel="nofollow">糖蛋白组学确定HOMER3为膀胱癌中缺氧和葡萄糖剥夺引发的潜在可靶向生物标志物。</a>&nbsp; | &nbsp;Peixoto, A., et al. 2021. J Exp Clin Cancer Res. 40: 191. PMID: 34108014</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/35871640/#&amp;dopt=Abstract" target="_blank" rel="nofollow">一名58岁女性患者脑脊液和血清样本中的抗Homer-3抗体，该患者患有亚急性小脑变性症和弥漫性乳腺癌。</a>&nbsp; | &nbsp;Klötzsch, C., et al. 2022. Neurol Res Pract. 4: 29. PMID: 35871640</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/35959384/#&amp;dopt=Abstract" target="_blank" rel="nofollow">病例报告和文献分析：与homer-3抗体相关的自身免疫性小脑共济失调。</a>&nbsp; | &nbsp;Wu, Q., et al. 2022. Front Neurol. 13: 951659. PMID: 35959384</li><li><a href="https://pubmed.ncbi.nlm.nih.gov/36672107/#&amp;dopt=Abstract" target="_blank" rel="nofollow">失忆性轻度认知障碍患者脑脊液中的Homer-3自身抗体。</a>&nbsp; | &nbsp;Hansen, N., et al. 2023. Brain Sci. 13: PMID: 36672107</li></ol></p></div>

<table><tbody><tr class="purple no-btm-brdr"><th>种属</th><th>基因名称</th><th>基因ID</th><th>染色体位置</th><th>亚型（mRNA）登录号</th><th>蛋白质登录号</th><th>OMIM&trade; 号码</th></tr><tr><td data-label="SPECIES">Human</td><td data-label ="GENE NAME">HOMER3</td><td data-label ="GENE ID"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=search&amp;term=9454" target="blank">Entrez Gene ID: 9454</a></td><td data-label ="CHROMOSOME LOCATION">19p13.11</td><td data-label ="ISOFORM ACCESSION NUMBER"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=XM_006722943&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">XM_006722943</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=XM_006722944&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">XM_006722944</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_001145721&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_001145721</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_001145722&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_001145722</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_001145724&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_001145724</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_004838&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_004838</a></td><td data-label ="PROTEIN ACCESSION NUMBER"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=protein&amp;cmd=search&amp;term=Q9NSC5" target="blank">UniProt ID: Q9NSC5</a></td><td data-label ="OMIM"><a href="https://omim.org/entry/604800" target="blank">604800</a></td></tr><tr><td data-label="SPECIES">Mouse</td><td data-label ="GENE NAME">Homer3</td><td data-label ="GENE ID"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&amp;cmd=search&amp;term=26558" target="blank">Entrez Gene ID: 26558</a></td><td data-label ="CHROMOSOME LOCATION">8 B3.3</td><td data-label ="ISOFORM ACCESSION NUMBER"><a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=XM_006509679&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">XM_006509679</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=XM_006509680&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">XM_006509680</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=XM_006509681&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">XM_006509681</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_001146153&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_001146153</a>, <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?term=NM_011984&amp;cmd=Search&amp;db=nuccore&amp;QueryKey=1" target="blank">NM_011984</a></td><td data-label ="PROTEIN ACCESSION NUMBER"><a href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=protein&amp;cmd=search&amp;term=Q99JP6" target="blank">UniProt ID: Q99JP6</a></td><td data-label ="OMIM">N/A</td></tr></tbody></table>

<div class="ov-grid"><p><h4>優選的 Homer 抗體是 <a href="homer-antibody-d-3">Homer 抗體</a> (D-3): sc-17842.</h4></p></div>

Homer-3 Antibody (G-2) - Western Blotting - Image 325103 

Homer-3 Antibody (G-2) - Western Blotting - Image 352443 

Homer-3 Antibody (G-2) - Western Blotting - Image 138930

Homer-3抗体 (G-2)

<div class="ov-grid"><ul><li>Homer-3抗体(G-2)是小鼠单克隆IgG<sub>1</sub> (<b>kappa轻链</b>)，规格为<b>200 &micro;g/ml</b></li><li>特异性抗原位于human物种的Homer-3的C-terminus的氨基酸337-360之间</li><li>推荐用于 mouse, rat 和 human 来源的Homer-3a and Homer-3b WB, IP, IF 和 ELISA检测</li><li>看 Homer (D-3): sc-17842，可查看有标记的 Homer-3 抗体，包括AC, HRP, FITC, PE, Alexa Fluor<sup>&reg;</sup> 488, 594, 647, 680 和 790</li><li><b><a href="m-igg-fc-bp-hrp" title="m-IgG Fc BP-HRP">m-IgG Fc BP-HRP</a></b>、 <b><a href="m-igg1-bp-hrp" title="m-IgG<sub translate="no">1</sub> BP-HRP">m-IgG<sub translate="no">1</sub> BP-HRP</a></b>和<b><a href="m-igg-kappa-bp-hrp" title="m-IgG&kappa; BP-HRP">m-IgG&kappa; BP-HRP</a></b>是Homer-3 Antibody (G-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Homer-3 Antibody (G-2) 打包提供<b>（请参阅下面的订购信息</b>）。</li></ul></div>

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            What application is the blocking peptide sc-365254 P appropriate for?
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            Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: &#10;&#10;https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
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附加Homer抗体，包括<b><a data-cat-id="cate-77732" style="text-decoration: underline" href="/browse/homer-1-antibodies"><b>Homer-1</b></a>, <a data-cat-id="cate-77734" style="text-decoration: underline" href="/browse/homer-1b-antibodies"><b>Homer-1b</b></a>, <a data-cat-id="cate-77735" style="text-decoration: underline" href="/browse/homer-1c-antibodies"><b>Homer-1c</b></a></b>和<b><a data-cat-id="cate-77737" style="text-decoration: underline" href="/browse/homer-3-antibodies"><b>Homer-3</b></a></b>

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Homer-3 抗体 (G-2): sc-365254

What application is the blocking peptide sc-365254 P appropriate for?