Date published: 2025-9-6
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hnRNP M Antibody (5-RE36) - Western Blotting - Image 64967
hnRNP M 抗体 (5-RE36): sc-134360. Hep G2 全细胞裂解液中 hnRNP M 表达的 Western 印迹分析.
hnRNP M Antibody (5-RE36) - Western Blotting - Image 64967
hnRNP M 抗体 (5-RE36): sc-134360. Hep G2 全细胞裂解液中 hnRNP M 表达的 Western 印迹分析.
hnRNP M Antibody (5-RE36) - Immunohistochemistry - Image 64966
hnRNP M 抗体 (5-RE36): sc-134360. 福尔马林固定, 石蜡包埋的人甲状腺结节性甲状腺肿组织的免疫过氧化物酶染色, 显示核定位.
hnRNP M Antibody (5-RE36) - Immunofluorescence - Image 64965
hnRNP M 抗体 (5-RE36): sc-134360. 甲醇固定的 Hep G2 细胞免疫荧光染色, 显示核定位.
hnRNP M 抗体 (5-RE36): sc-134360. Hep G2 全细胞裂解液中 hnRNP M 表达的 Western 印迹分析.

hnRNP M 抗体 (5-RE36): sc-134360

3.8(4)
寫評論提問

说明书
  • hnRNP M抗体(5-RE36)是小鼠单克隆IgG2a κ, 在5篇文献中引用，规格为100 µg/ml
  • 针对human重组hnRNP M蛋白的抗原性氨基酸
  • 推荐用于 mouse, rat 和 human 来源的hnRNP M WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 hnRNP M1-4 (1D8): sc-20002，可查看有标记的 hnRNP M 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前，我们还没有完成hnRNP M 抗体 (5-RE36)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

此外 hnRNP 抗体 包括 hnRNP A, hnRNP A1, hnRNP A2, hnRNP B, hnRNP B1, hnRNP C1, hnRNP C2, hnRNP E1, hnRNP E2和hnRNP F

异质核核糖核蛋白（hnRNP）是一组多肽，它们有助于mRNA转录、前mRNA加工以及成熟mRNA向细胞质的转运和翻译。它们还结合异质核RNA（hnRNA），hnRNA是由RNA聚合酶II产生的转录本。大约有20种已知的hnRNP蛋白，它们的复合物是剪接体的主要成分。大多数hnRNP蛋白成分定位于细胞核；然而，一些在细胞核和细胞质之间穿梭，如hnRNP E1和E2。hnRNP E1可能在细胞质中作为翻译调节蛋白发挥作用，而hnRNP E2稳定mRNA以增强脊髓灰质炎病毒mRNA翻译。hnRNP M参与前mRNA剪接和应激诱导的瞬时剪接阻滞。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP M 抗体 (5-RE36) 参考文献:

  1. hnRNPM 的细胞类型限制活性通过调节替代剪接促进乳腺癌转移。  |  Xu, Y., et al. 2014. Genes Dev. 28: 1191-203. PMID: 24840202
  2. 体外鉴定非酒精性脂肪肝相关蛋白 hnRNPM。  |  Takino, J., et al. 2015. World J Gastroenterol. 21: 1784-93. PMID: 25684943
  3. hnRNPM 和 ESRP1 在 EMT 过程中对替代剪接的核心调控。  |  Harvey, SE., et al. 2018. RNA. 24: 1326-1338. PMID: 30042172
  4. Matrin-3 中的 RNA 识别基团通过与 hnRNPM 的相互作用介导神经退行性变。  |  Ramesh, N., et al. 2020. Acta Neuropathol Commun. 8: 138. PMID: 32811564
  5. hnRNPM 缺乏会通过破坏突触可塑性导致认知缺陷。  |  Akinyemi, AR., et al. 2021. Neurosci Lett. 751: 135824. PMID: 33727124
  6. circPTPN12通过hnRNPM/IL-6/STAT3通路促进肾癌的进展和舒尼替尼耐药性。  |  Shou, Y., et al. 2023. Cell Death Dis. 14: 232. PMID: 37002206
  7. 牛白血病病毒衍生的长非编码 RNA AS1-S 与牛 hnRNPM 结合，并改变 hnRNPM 与宿主 mRNA 之间的相互作用。  |  Andoh, K., et al. 2023. Microbiol Spectr. 11: e0085523. PMID: 37671887
  8. 环状 RNA-circLRP6 通过促进 hnRNPM 介导的 FGF-9 的表达，保护心肌细胞免受缺氧诱导的凋亡。  |  Ding, W., et al. 2024. FEBS J. 291: 1246-1263. PMID: 38105623
  9. RNA 结合蛋白 hnRNPM 和 ELAVL1 在核酸传感器 cGAS 和 RIG-I 的下游促进Ⅰ型干扰素诱导。  |  Kirchhoff, A., et al. 2025. EMBO J. 44: 824-853. PMID: 39707025
  10. HnRNPM 通过招募 PTBP1 调节生殖细胞中的替代剪接。  |  Lv, P., et al. 2025. Reprod Biol Endocrinol. 23: 3. PMID: 39780247

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP M 抗体 (5-RE36)

sc-134360
100 µg/ml
$333.00

What is the epitope sequence to which the antibody binds? I want to express truncated product

Asked by: sfu11
Thank you for your question. The epitope for this antibody maps within amino acids 50-120 of hnRNP M of human origin (accession#P52272). The exact epitope has not been mapped.
Answered by: Tech Service
Date published: 2019-08-14

Can sc-134360: hnRNP M (5-RE36) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Randy McDonald
Thank you for your question. Yes, sc-134360: hnRNP M (5-RE36) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 2 out of 5 by from the signal was not specific in our conditionWestern blot analysis of hnRNP M expression in human Neural Progenitor cells (hNPCs) after nuclear (N) and cytoplasmic (C) fractionation. We purchased this product but no clear and specific band for this protein was detected in our condition
Date published: 2021-09-03
Rated 5 out of 5 by from Excellent!This antibody works great in western blot analysis of hnRNP M expression in Hep G2 whole cell lysate.
Date published: 2017-02-01
Rated 4 out of 5 by from Wonderful immunoperoxidase nuclear stainingWonderful immunoperoxidase nuclear staining in formalin-fixed, paraffin-embedded human thyroid nodular goiter tissue. -SCBT QC
Date published: 2015-05-06
Rated 4 out of 5 by from Good specificity and signal strength in HepGood specificity and signal strength in Hep G2 whole cell lysate. -SCBT QC
Date published: 2015-03-12
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hnRNP M 抗体 (5-RE36) is rated 3.8 out of 5 by 4.
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