Date published: 2026-10-19

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hnRNP A2/B1 抗体 (DP3B3): sc-32316

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  • hnRNP A2/B1抗体(DP3B3)是小鼠单克隆IgG2a κ, 在35篇文献中引用,规格为200 µg/ml
  • 针对细菌表达的human来源的His-hnRNP A2
  • 抗-hnRNP A2/B1 抗体 (DP3B3) 推荐用于 WB, IP 和 IF,检测mouse, rat 和human 来源的 hnRNP A2 and hnRNP B1; 也和以下物种反应,包括: 和 bovine, porcine and canine
  • 抗hnRNP A2/B1抗体(DP3B3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 2a BP-HRP">m-IgG2a BP-HRP是hnRNP A2/B1 Antibody (DP3B3) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与hnRNP A2/B1 Antibody (DP3B3) 打包提供(请参阅下面的订购信息)。
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hnRNP A2/B1 抗体(DP3B3)是一种小鼠单克隆 IgG2a kappa 轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)检测小鼠、大鼠和人类来源的 hnRNP A2 和 hnRNP B1 蛋白。抗hnRNP A2/B1抗体(DP3B3)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。异质核糖核蛋白(hnRNPs)在mRNA代谢中发挥着关键作用,包括转录、前mRNA处理以及将成熟的mRNA转运到细胞质中进行翻译。hnRNP A2和hnRNP B1通过影响剪接位点选择和调节剪接因子活性来调节前mRNA剪接。这种调节对于产生功能性mRNA至关重要,因为不正确的剪接会产生非功能性或有害的蛋白质,从而导致各种疾病。hnRNPs的A/B亚家族,包括hnRNP A1、A2/B1、A3和A0,主要定位于细胞核,但有些成员在细胞核和细胞质之间穿梭,这凸显了它们在基因表达调控中的动态作用。了解hnRNP A2/B1在剪接体中的功能和相互作用对于阐明基因调控的复杂性和潜在的疾病影响仍然至关重要。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP A2/B1 抗体 (DP3B3) 参考文献:

  1. 非肿瘤性肺泡细胞中的hnRNP A2/B1蛋白。  |  Satoh, H., et al. 2003. Lung. 181: 219-25. PMID: 14692562
  2. hnRNP-A2/B1在调节芳香烃受体配体敏感性方面的新作用。  |  Cho, SW., et al. 2015. Arch Toxicol. 89: 2027-38. PMID: 25224401
  3. 敲除 hnRNP A2/B1 对抑制胶质母细胞瘤细胞侵袭, 生长和存活的影响  |  Deng, J., et al. 2016. Mol Neurobiol. 53: 1132-1144. PMID: 25586062
  4. 细胞hnRNP A2/B1与甲型流感病毒核蛋白相互作用并影响病毒复制。  |  Chang, CK., et al. 2017. PLoS One. 12: e0188214. PMID: 29145464
  5. 下调hnRNP A2/B1可抑制宫颈癌细胞的增殖、侵袭和细胞周期,并通过PI3K/AKT信号通路触发细胞凋亡。  |  Shi, X., et al. 2018. Oncol Rep. 39: 939-950. PMID: 29328485
  6. 对染色质上hnRNP A2/B1-RNA结合的全局分析突出了长链非编码RNA的相互作用。  |  Nguyen, ED., et al. 2018. RNA Biol. 15: 901-913. PMID: 29938567
  7. hnRNP A2/B1在RNA生物学和疾病中的作用。  |  Liu, Y. and Shi, SL. 2021. Wiley Interdiscip Rev RNA. 12: e1612. PMID: 32588964
  8. 对hnRNP A2/B1同源二聚体和DNA识别的结构洞察。  |  Liu, Y., et al. 2023. J Mol Biol. 435: 167920. PMID: 36528084
  9. 胶质母细胞瘤通过上调hnRNP A2/B1的SUMO化来消除肿瘤抑制因子miR-204-3p,从而在缺氧条件下加速血管生成。  |  Guo, Q., et al. 2023. Cell Death Dis. 14: 147. PMID: 36810326
  10. 基于使用XGBoost的简化热蛋白质组分析方法,HnRNP A2/B1作为基于雷公藤甲素(triptolide)的潜在抗肿瘤靶标。  |  Chen, P., et al. 2023. Phytomedicine. 117: 154929. PMID: 37329754

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP A2/B1 抗体 (DP3B3)

sc-32316
200 µg/ml
$322.00

hnRNP A2/B1 (DP3B3): m-IgG2a BP-HRP 套装

sc-545916
200 µg Ab; 10 µg BP
$361.00

hnRNP A2/B1 抗体 (DP3B3) AC

sc-32316 AC
500 µg/ml, 25% agarose
$424.00

hnRNP A2/B1 抗体 (DP3B3) HRP

sc-32316 HRP
200 µg/ml
$322.00

hnRNP A2/B1 抗体 (DP3B3) FITC

sc-32316 FITC
200 µg/ml
$336.00

hnRNP A2/B1 抗体 (DP3B3) PE

sc-32316 PE
200 µg/ml
$349.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 488

sc-32316 AF488
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 546

sc-32316 AF546
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 594

sc-32316 AF594
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 647

sc-32316 AF647
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 680

sc-32316 AF680
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (DP3B3) Alexa Fluor® 790

sc-32316 AF790
200 µg/ml
$364.00

What is the exact epitope recognized by hnRNP A2/B1 (DP3B3): sc-32316 monoclonal antibody?

Asked by: cjMara
hnRNP A2/B1 (DP3B3): sc-32316 is a mouse monoclonal raised against bacterially expressed His-hnRNP A2 of human origin. The exact epitope has not been determined.
Answered by: Technical Support 8
Date published: 2017-01-19
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Rated 5 out of 5 by lzyang from 功能很出色,效果很好这个产品我用起来感觉不错,抗体孵出来了,很清晰,特异性也可以。下次准备申请别的蛋白的抗体试用装,如果效果好的话会继续购买正装。
Date published: 2023-07-11
Rated 5 out of 5 by arnoldone from It works perfectly in WBhnRNP A2B1 Antibody (DP3B3): sc-32316. Western blot analysis of hnRNP A2B1 expression in human Neural Progenitor cells (hNPCs) after nuclear (N) and cytoplasmic (C) fractionation.
Date published: 2021-09-03
Rated 5 out of 5 by Bertrand from Works for WB of endogenousDetects a band just beneath 37 kDa at 1/200 on HEK293T cell lysate
Date published: 2017-09-13
Rated 5 out of 5 by huangtao from Nice Western Blot data of SNAT2 expression in nonProduced beautiful immunofluorescence membrane and cytoplasmic vesicles staining in methanol-fixed HeLa cells.Nice Western Blot data of SNAT2 expression in non-transfected and human SNAT2 transfected 293T whole cell lysates.
Date published: 2017-07-10
Rated 5 out of 5 by Bill28 from SuperbOutstanding product for both western blot and IHC staining applications
Date published: 2017-02-03
Rated 5 out of 5 by jerojero from Excellent!This antibody works great in western blot analysis of hnRNP A2/B1 expression in HeLa and Jurkat nuclear extracts and A549 and Meg-01 whole cell lysates.
Date published: 2017-01-17
Rated 4 out of 5 by SH from Strong band in WB in KStrong band in WB in K-562 nuclear extract. -SCBT QC
Date published: 2015-03-31
Rated 4 out of 5 by JT from Published data for WB and IHC (p) in humanPublished data for WB and IHC (p) in human liver tumor cells. -SCBT Publication Review
Date published: 2015-03-17
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hnRNP A2/B1抗体 (DP3B3) is rated 4.5 out of 5 by 11.
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