Date published: 2026-10-19

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hnRNP A2/B1 抗体 (B-7): sc-374053

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  • hnRNP A2/B1 抗体 B-7 是小鼠单克隆 IgG2b κ,hnRNP A2/B1抗体, 在22篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的hnRNP A2/B1的内部区域内的氨基酸209-243之间
  • hnRNP A2/B1 抗体 (B-7) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 hnRNP A2/B1; 也和以下物种反应,包括: 和 equine, canine and porcine
  • hnRNP A2/B1 抗体 (B-7) 可偶联 琼脂糖 用于 IP; 偶联 HRP 用于 WB, IHC(P) 和 ELISA; 还可偶联 FITC 用于 IF, IHC(P) 和 FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP和 2b BP-HRP">m-IgG2b BP-HRP是hnRNP A2/B1 Antibody (B-7) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂,这些试剂现与hnRNP A2/B1 Antibody (B-7) 打包提供(请参阅下面的订购信息)。
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hnRNP A2/B1抗体(B-7)是一种IgG2b κ小鼠单克隆hnRNP A2/B1抗体(也称为HNRNPA2B1抗体),可通过WB、IP、IF、IHC(P)和ELISA等方法检测小鼠、大鼠和人类的hnRNP A2/B1蛋白。hnRNP A2/B1抗体(B-7)既可以以非偶联的抗hnRNP A2/B1抗体形式存在,也可以以多种偶联形式的抗hnRNP A2/B1抗体存在,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。异质性核核糖核蛋白(hnRNPs)是一组多肽,有助于mRNA转录和前mRNA处理,以及成熟mRNA向细胞质的转运和翻译。它们还与异质性核RNA(hnRNA)结合,这是由RNA聚合酶II产生的转录物。已知大约有20种hnRNP蛋白,它们的复合物是剪接体的主要组成部分。大多数hnRNP蛋白定位于细胞核;然而有些在细胞核和细胞质之间穿梭。hnRNPs的A/B亚家族包括A1、A2/B1、A3和A0,在非洲爪蟾中,hnRNP A1、A2和A3在整个发育过程以及成年组织中普遍表达。hnRNP A1和A2/B1通过直接拮抗各种剪接因子的结合以及影响前mRNA上的剪接位点选择来调节前mRNA的加工。hnRNP A0基因与其他A/B家族成员不同,它编码一种低丰度蛋白,与mRNA稳定性有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

hnRNP A2/B1 抗体 (B-7) 参考文献:

  1. 人类癌细胞系中hnRNP A2/B1蛋白的表达。  |  Satoh, H., et al. 2000. Int J Oncol. 16: 763-7. PMID: 10717246
  2. 正常乳腺和肿瘤性乳腺癌中早期肺癌检测标记物--异质核糖核蛋白-A2/B1(hnRNP-A2/B1)的差异表达。  |  Zhou, J., et al. 2001. Breast Cancer Res Treat. 66: 217-24. PMID: 11510693
  3. 在长期缺氧的肿瘤细胞中,hnRNP A2/B1的表达会降低。  |  Garayoa, M., et al. 2003. Am J Respir Cell Mol Biol. 28: 80-5. PMID: 12495935
  4. hnRNP A2/B1的基因诱捕突变:新霉素抗性基因中隐性的3'剪接位点允许被破坏的细胞基因继续表达。  |  Roshon, M., et al. 2003. BMC Genomics. 4: 2. PMID: 12546712
  5. hnRNP A2/B1剪接体的亚细胞分布和转运功能的差异。  |  Han, SP., et al. 2010. Traffic. 11: 886-98. PMID: 20406423
  6. 剪接因子hnRNP A2/B1调节肿瘤抑制基因的剪接,是胶质母细胞瘤的致癌驱动因子。  |  Golan-Gerstl, R., et al. 2011. Cancer Res. 71: 4464-72. PMID: 21586613
  7. 白塞氏病和链球菌患者的血清都会刺激内皮细胞膜上hnRNP A2/B1的表达。  |  Cho, SB., et al. 2013. Scand J Rheumatol. 42: 241-6. PMID: 23445441
  8. 通过结合hnRNP D蛋白和hnRNP A2/B1到上游AUAGUA RNA序列,抑制HPV-16晚期L1 5'-剪接位点SD3632。  |  Li, X., et al. 2013. Nucleic Acids Res. 41: 10488-508. PMID: 24013563
  9. 在培养的海马神经元中,神经元活动通过 BDNF 依赖性机制诱导 hnRNP A2/B1 的突触传递。  |  Leal, G., et al. 2014. PLoS One. 9: e108175. PMID: 25286195
  10. β-细辛醚通过抑制HnRNP A2/B1介导的途径诱导人胶质瘤U251细胞凋亡和细胞周期停滞。  |  Li, L., et al. 2018. Molecules. 23: PMID: 29751524

订购信息

产品名称产品编号规格价格数量收藏夹

hnRNP A2/B1 抗体 (B-7)

sc-374053
200 µg/ml
$322.00

hnRNP A2/B1 (B-7): m-IgG Fc BP-HRP 套装

sc-525935
200 µg Ab; 10 µg BP
$361.00

hnRNP A2/B1 (B-7): m-IgG2b BP-HRP 套装

sc-549649
200 µg Ab; 10 µg BP
$361.00

hnRNP A2/B1 抗体 (B-7) AC

sc-374053 AC
500 µg/ml, 25% agarose
$424.00

hnRNP A2/B1 抗体 (B-7) HRP

sc-374053 HRP
200 µg/ml
$322.00

hnRNP A2/B1 抗体 (B-7) FITC

sc-374053 FITC
200 µg/ml
$336.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 488

sc-374053 AF488
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 546

sc-374053 AF546
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 594

sc-374053 AF594
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 647

sc-374053 AF647
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 680

sc-374053 AF680
200 µg/ml
$364.00

hnRNP A2/B1 抗体 (B-7) Alexa Fluor® 790

sc-374053 AF790
200 µg/ml
$364.00

hnRNP A2/B1 (B-7) 中和勝肽

sc-374053 P
100 µg/0.5 ml
$69.00

What application is the blocking peptide sc-374053 P appropriate for?

Asked by: TinTin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by RJ_DI04 from Works well for immunofluorescenceWe have gotten very good results for this antibody using porcine cells.
Date published: 2017-10-16
Rated 5 out of 5 by Bertrand from Works for WB of endogenousDetects a band of the correct size at 1/200 on HEK293T cell lysate
Date published: 2017-09-13
Rated 4 out of 5 by ping890414 from Really good antibodyStrong band for WB of Rat tissue NE(liver,Spleen,Lung,Kidney,Testis tissue ). 1:1000
Date published: 2017-04-05
Rated 5 out of 5 by HLee from Great resultWestern blotting was performed with this antibody and we got strong bands from human epithelial cell lysates (Beas2B).
Date published: 2017-03-20
Rated 5 out of 5 by Just15 from Works wellWorks well for WB. Tested at 1:1000. Happy with the antibody.
Date published: 2017-03-06
Rated 5 out of 5 by Dr Ninau Qelp from Really good antibodyhnRNP A2/B1 (B-7) works great for WB, IF, and IHC(P). Strong band in positive control K-562 nuclear extract: sc-2130.
Date published: 2017-02-03
Rated 5 out of 5 by JM from Worked well for Western in Jurkat and HeLaWorked well for Western in Jurkat and HeLa nuclear extracts. -SCBT QC
Date published: 2015-04-27
Rated 5 out of 5 by SF from WB: Great antibody dataWB: Great antibody data, positive in K-562 and THP-1 nuclear extracts. -SCBT QC
Date published: 2015-04-05
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hnRNP A2/B1抗体 (B-7) is rated 4.9 out of 5 by 10.
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