m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) is the preferred secondary detection reagent for hnRNP A2/B1 Antibody (B-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with hnRNP A2/B1 Antibody (B-7) (see ordering information below).
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Labware ships FedEx Ground free of charge to the contiguous US
hnRNP A2/B1 Antibody (B-7) is a high quality monoclonal hnRNP A2/B1 antibody (also designated HNRNPA2B1 antibody) suitable for the detection of the hnRNP A2/B1 protein of mouse, rat and human origin. hnRNP A2/B1 Antibody (B-7) is available as both the non-conjugated anti-hnRNP A2/B1 antibody form, as well as multiple conjugated forms of anti-hnRNP A2/B1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of poly-peptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome. The majority of hnRNP proteins are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm. The A/B subfamily of hnRNPs include A1, A2/B1, A3 and A0, and in Xenopus, hnRNP A1, A2 and A3 are ubiquitously expressed throughout development as well as in adult tissues. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The hnRNP A0 gene is distinct from the other A/B family members, and it encodes a low-abundance protein, which is implicated in mRNA stability.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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