Date published: 2025-9-9

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Hemoglobin γ 抗体 (51-7): sc-21756

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说明书
  • Hemoglobin γ抗体(51-7)是小鼠单克隆IgG1 κ, 在60篇文献中引用,规格为200 µg/ml
  • 针对human血红蛋白的
  • Hemoglobin gamma 抗体 (51-7) 推荐用于WB, IP, IF, IHC(P) 和 FCM,检测human 来源的 Hemoglobin γ
  • 抗Hemoglobin gamma抗体(51-7)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Hemoglobin γ (51-7): sc-21756免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 是 Hemoglobin γ 抗体 (51-7) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Hemoglobin γ 抗体 (51-7) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

血红蛋白γ抗体(51-7)是一种针对人类血红蛋白γ(也称为血红蛋白γ、HBG1或HBG2)的小鼠单克隆IgG1 kappa轻链抗体。血红蛋白γ单克隆抗体(51-7)可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和流式细胞术(FCM)等技术,特异性检测人源血红蛋白γ。血红蛋白γ是胎儿血红蛋白(Hb F)的组成部分,由两条α(α)链和两条γ(γ)链组成,是胎儿发育过程中血红蛋白的主要形式。血红蛋白γ位于红细胞的细胞质中,由于它比成人血红蛋白对氧的亲和力更强,因此在从母亲向胎儿输送氧气方面发挥着至关重要的作用。由于γ血红蛋白在细胞质中的定位,它能够在红细胞内高效结合和释放氧气,从而为快速发育的胎儿组织提供充足的氧气。出生后,随着β(β)链逐渐取代γ链形成成人血红蛋白(Hb A),γ血红蛋白的表达会逐渐减少。研究γ血红蛋白对于了解胎儿发育和调查胎儿血红蛋白遗传性持续存在和血红蛋白病等疾病至关重要。血红蛋白γ(51-7)抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物,为各种实验应用提供了多功能性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Hemoglobin γ 抗体 (51-7) 参考文献:

  1. 胎儿血红蛋白γ亚基对四聚物强度的N端贡献:亚基接触的远程效应。  |  Yagami, T., et al. 2002. Protein Sci. 11: 27-35. PMID: 11742119
  2. 在无细胞系统中表达的人类血红蛋白(Hb)β-和γ-球蛋白链与α-球蛋白链组装成 Hb A 和 Hb F。  |  Adachi, K., et al. 2002. J Biol Chem. 277: 13415-20. PMID: 11827978
  3. 台湾库利氏贫血患者血红蛋白γ链的分析。  |  Lin, LI., et al. 1992. J Formos Med Assoc. 91: 121-5. PMID: 1285319
  4. 镰状血红蛋白纤维组装中相互作用的联系:α-链 AB 区突变产生的抑制作用被其 EF 角的突变所抵消。  |  Sudha, R., et al. 2004. J Biol Chem. 279: 20018-27. PMID: 14982923
  5. 人类α-血红蛋白通过其伴侣蛋白转移到β-血红蛋白:一种新状态的证据。  |  Baudin-Creuza, V., et al. 2004. J Biol Chem. 279: 36530-3. PMID: 15220346
  6. AHSP 介导稳定α-血红蛋白的分子机制。  |  Feng, L., et al. 2004. Cell. 119: 629-40. PMID: 15550245
  7. 母体外周血中胎儿血红蛋白γ链信使RNA(HbF-γ mRNA)的定量分析。  |  Okuda, T., et al. 2004. Prenat Diagn. 24: 881-6. PMID: 15565590
  8. GM-CSF存在下诱导耐受性树突状细胞(DCs)与免疫原性树突状细胞(DCs)受单磷酸脂A(MPLA)与谷胱甘肽和胎儿血红蛋白γ链结合的信号强度调节。  |  Khatri, I., et al. 2009. Immunol Lett. 124: 44-9. PMID: 19379773
  9. 人类 zeta-globin 基因复合物长度多态性的分子基础。  |  Goodbourn, SE., et al. 1983. Proc Natl Acad Sci U S A. 80: 5022-6. PMID: 6308667
  10. 人类α-球蛋白α1和α2基因座的同源性和协同进化。  |  Liebhaber, SA., et al. 1981. Nature. 290: 26-9. PMID: 7010180
  11. 德国人群低密度脂蛋白受体、糖蛋白A、血红蛋白γG、D7S8和组特异性成分的基因座数据。  |  Huckenbeck, W., et al. 1995. Anthropol Anz. 53: 193-8. PMID: 7486878
  12. 血红蛋白的多重功能  |  Giardina, B., et al. 1995. Crit Rev Biochem Mol Biol. 30: 165-96. PMID: 7555018

订购信息

产品名称产品编号规格价格数量收藏夹

Hemoglobin γ 抗体 (51-7)

sc-21756
200 µg/ml
$316.00

Hemoglobin γ (51-7): m-IgG Fc BP-HRP 套装

sc-525505
200 µg Ab; 10 µg BP
$354.00

Hemoglobin γ 抗体 (51-7) AC

sc-21756 AC
500 µg/ml, 25% agarose
$416.00

Hemoglobin γ 抗体 (51-7) HRP

sc-21756 HRP
200 µg/ml
$316.00

Hemoglobin γ 抗体 (51-7) FITC

sc-21756 FITC
200 µg/ml
$330.00

Hemoglobin γ 抗体 (51-7) PE

sc-21756 PE
200 µg/ml
$343.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 488

sc-21756 AF488
200 µg/ml
$357.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 546

sc-21756 AF546
200 µg/ml
$357.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 594

sc-21756 AF594
200 µg/ml
$357.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 647

sc-21756 AF647
200 µg/ml
$357.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 680

sc-21756 AF680
200 µg/ml
$357.00

Hemoglobin γ 抗体 (51-7) Alexa Fluor® 790

sc-21756 AF790
200 µg/ml
$357.00

I am investigating the role of hemoglobin in the heart muscle. May I ask you to send me an aliqout of 10 µg GRATIS Sample of Hemoglobin γ (51-7): sc-21756 ? in case if we could detect the expected effect we will order this antibody

Asked by: Anonymous
Thank you for your question. For information on how to receive a 10 µg sample please contact your local customer servise via europe@scbt.com
Answered by: Tech Support Europe
Date published: 2021-09-07

We need purified antibody free from other proteins so that we can conjugate to a lanthanide. Do this antibody come purified or is it available in such a preparation?

Asked by: rjgibbons
Thank you for your question. We should be able to provide this antibody in alternative formulations. Please get in touch with our technical service team to arrange a quote.
Answered by: Tech Support Europe
Date published: 2020-07-01

I am working with zebrafish samples, will this antibody work?

Asked by: Cweed
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: TechService7
Date published: 2016-12-30
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Rated 5 out of 5 by from good and specificvery good and specific. Might have been able to pick up both gamma species on a 14% gel. Signal is lower than for alpha and beta but works for both RBC and HSC-derived cells.
Date published: 2022-12-12
Rated 5 out of 5 by from excellent HBG antibodyused for detection of HbF in western blot with 1:1000 dilution, excellent quality!
Date published: 2022-08-05
Rated 4 out of 5 by from It worked for usI used this antibody for WB of K562 cells. 20 ug protein, 1/200 dilution of primary antibody, 1/1000 dilution of secondary (anti-mouse-HRP). Gave a strong signal by chemiluminescence (Clarity ECL).
Date published: 2018-08-22
Rated 5 out of 5 by from Works for WBSpecific band ~15kDa in Western with cord blood samples
Date published: 2017-10-27
Rated 5 out of 5 by from nice quality antibodyI found this antibody shows nice quality controled,I got clear band at 18kda.
Date published: 2017-06-14
Rated 5 out of 5 by from excellent antibodyI have used this antibody for WB and IF in the past five years. It is a very nice antobody! I will always use it all the time in the future!
Date published: 2017-04-29
Rated 5 out of 5 by from Versitle AntibodyGreat antibody! Strong signal by WB, IHC(P) and FCM!
Date published: 2017-01-16
Rated 5 out of 5 by from Superb westernSuperb western, strong signal, low background, good ihc
Date published: 2017-01-01
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Hemoglobin γ抗体 (51-7) is rated 4.9 out of 5 by 15.
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