Date published: 2025-9-8

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granzyme B 抗体 (GRB7): sc-73620

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说明书
  • granzyme B 抗体 GRB7 是小鼠单克隆 IgG2a, 在2篇文献中引用,提供 50 µg/0.5 ml
  • 针对全长granzyme B,human起源
  • 推荐用于 human 来源的granzyme B WB, IP, IF 和 IHC(P)检测
  • 看 granzyme B (2C5): sc-8022,可查看有标记的 granzyme B 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成granzyme B 抗体 (GRB7)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

颗粒酶B抗体(GRB7)是一种IgG2a小鼠单克隆颗粒酶B抗体,能够通过WB, IF 和 IHC(P)检测人源的颗粒酶B。该颗粒酶B抗体(GRB7)可作为非偶联的抗颗粒酶B抗体。Granzyme A和Granzyme B是丝氨酸蛋白酶,可以介导细胞毒性T淋巴细胞(CTL)和天然杀伤细胞(NK)中的凋亡信号传导。Granzyme A和Granzyme B都以不活性的前酶的形式合成,它们储存在细胞毒性颗粒中,并在效应细胞脱颗粒期间释放出来。在激活的CTLs中,Granzyme A和Granzyme B由猫科肽C加工和激活,然后通过两种不同的途径诱导凋亡。Granzyme B以蛋白酶的方式剪切和激活包括caspase-3、caspase-6、caspase-7和caspase-9在内的硫氨酸蛋白酶家族成员。被剪切后,这些caspases组装成活性全酶,然后通过涉及核层蛋白和PARP(多聚(ADP核糖)聚合酶)的定义蛋白酶级联介导凋亡。Granzyme A介导凋亡的激活,通过诱导单链DNA断裂、膜扰动和核凝聚,这是一种独立于caspase激活或caspase蛋白酶级联的替代途径。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

granzyme B 抗体 (GRB7) 参考文献:

  1. 基于人颗粒酶B的靶向细胞溶解融合蛋白。  |  Hlongwane, P., et al. 2018. Biomedicines. 6: PMID: 29925790
  2. 乳腺癌引流淋巴结中活化的B细胞产生的颗粒酶B。  |  Arabpour, M., et al. 2019. Mol Immunol. 114: 172-178. PMID: 31357083
  3. 颗粒酶 B 通过靶向分泌因子削弱细菌毒性  |  León, DL., et al. 2020. iScience. 23: 100932. PMID: 32151975
  4. 炎症性疾病中的颗粒酶B:细胞凋亡、炎症、细胞外基质重塑、上皮-间质转化和纤维化。  |  Velotti, F., et al. 2020. Front Immunol. 11: 587581. PMID: 33262766
  5. 抑制颗粒酶B可减轻自身免疫性水疱病的严重程度。  |  Hiroyasu, S., et al. 2021. Nat Commun. 12: 302. PMID: 33436591
  6. 相互作用网络汇聚于颗粒酶B的免疫抑制作用:肿瘤微环境中的特殊位置。  |  Wang, W., et al. 2021. Front Immunol. 12: 670324. PMID: 33868318
  7. 系统性红斑狼疮中产生颗粒酶B的调节性B细胞受损。  |  Bai, M., et al. 2021. Mol Immunol. 140: 217-224. PMID: 34749262
  8. 小鼠调节性T细胞利用颗粒酶B促进肿瘤转移。  |  Tibbs, E., et al. 2023. Cancer Immunol Immunother. 72: 2927-2937. PMID: 36826509
  9. 颗粒酶B可作为控制COPD炎症过程的效应分子。  |  Kim, WD. and Sin, DD. 2024. COPD. 21: 1-11. PMID: 38314671
  10. 颗粒酶B PET成像用于评估炎症性肠病的疾病活动性。  |  Heidari, P., et al. 2024. J Nucl Med. 65: 1137-1143. PMID: 38754959

订购信息

产品名称产品编号规格价格数量收藏夹

granzyme B 抗体 (GRB7)

sc-73620
50 µg/0.5 ml
$316.00

What is the concentration of sc-73620: granzyme B (GRB7) monoclonal antibody?

Asked by: TinTin
Thank you for your question. The concentration of granzyme B (GRB7): sc-73620 has not been characterized. This antibody is provided as 500 µl of supernatant
Answered by: Technical Support
Date published: 2017-03-24
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Rated 4 out of 5 by from Performed well in WB in NKPerformed well in WB in NK-92 whole cell lysate. -SCBT QC
Date published: 2015-03-20
Rated 4 out of 5 by from Produced strongProduced strong, clear band of interest in WB in human granzyme B transfected 293T whole cell lysate. -SCBT QC
Date published: 2015-03-10
Rated 4 out of 5 by from Robust band of interest seen in WB in humanRobust band of interest seen in WB in human granzyme B transfected 293T whole cell lysate. -SCBT QC
Date published: 2014-03-10
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granzyme B 抗体 (GRB7) is rated 4.0 out of 5 by 3.
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