Date published: 2025-9-7

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granuphilin 抗体 (C-3): sc-374544

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说明书
  • granuphilin 抗体 C-3 是小鼠单克隆 IgG1 κ,granuphilin抗体, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列44-298位于human物种的granuphilin的N-terminus附近
  • granuphilin 抗体 (C-3) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 granuphilin
  • 抗granuphilin抗体(C-3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取granuphilin (C-3): sc-374544免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是granuphilin Antibody (C-3) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与granuphilin Antibody (C-3) 打包提供(请参阅下面的订购信息)。

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関連項目

Granuphilin抗体(C-3)是一种IgG1 κ小鼠单克隆Granuphilin抗体(也称为Granuphilin抗体),可通过WB、IP、IF和ELISA检测人源的Granuphilin蛋白。Granuphilin抗体(C-3)既可以是非偶联的抗Granuphilin抗体形式,也可以是多种偶联形式的抗Granuphilin抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Granuphilin,也被称为突触结合蛋白样蛋白4或exophilin 2,是突触结合蛋白样蛋白家族的一员。在啮齿动物中,已鉴定出两种异构体,即Granuphlin-a和Granuphilin-b,人类中也存在选择性剪接。Granuphilin-b是一种较短的异构体,其C端序列与较长的异构体不同。Granuphilin是由Syntaxin 1A(STX1A)和Rab 27A组成的三元复合物的一部分。Granuphilin与质膜上Syntaxin 1A的相互作用受Rab 27A的调节。Granuphilin是一种主要表达于胰腺β细胞和垂体腺的外周膜蛋白。它已被检测到存在于分泌颗粒和靠近质膜的位置。在胰腺中,Granuphilin与含胰岛素的囊泡相互作用,同时在胰腺和垂体中,Granuphilin调节激素的分泌和致密核心颗粒的胞吐作用。Granuphilin的过度表达会增强基础胰岛素分泌,但也会抑制高K+诱导的胰岛素分泌。破坏Granuphilin与Rab 27A或Syntaxin 1A结合的突变可能会损害Granuphilin对胰岛素分泌的影响,从而使Granuphilin成为胞吐途径中可能的调节因子。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

granuphilin 抗体 (C-3) 参考文献:

  1. 胰腺β细胞蛋白granuphilin与Rab3和Munc-18结合并控制外吞。  |  Coppola, T., et al. 2002. Mol Biol Cell. 13: 1906-15. PMID: 12058058
  2. Granuphilin 通过与 syntaxin 1a 相互作用调节分泌颗粒的外泌。  |  Torii, S., et al. 2002. Mol Cell Biol. 22: 5518-26. PMID: 12101244
  3. SLP4-a/granuphilin-a以依赖于Munc18-2的方式与syntaxin-2/3相互作用。  |  Fukuda, M., et al. 2005. J Biol Chem. 280: 39175-84. PMID: 16186111
  4. Granuphilin 可使胰岛素颗粒与融合机制分子对接。  |  Gomi, H., et al. 2005. J Cell Biol. 171: 99-109. PMID: 16216924
  5. Rab27a 效应子 granuphilin 在胰岛素外吞过程中的功能分析  |  Izumi, T., et al. 2005. Methods Enzymol. 403: 216-29. PMID: 16473589

订购信息

产品名称产品编号规格价格数量收藏夹

granuphilin 抗体 (C-3)

sc-374544
200 µg/ml
$316.00

granuphilin (C-3): m-IgG Fc BP-HRP 套装

sc-529767
200 µg Ab; 10 µg BP
$354.00

granuphilin (C-3): m-IgGκ BP-HRP 套装

sc-522773
200 µg Ab, 40 µg BP
$354.00

granuphilin (C-3): m-IgG1 BP-HRP 套装

sc-543678
200 µg Ab; 20 µg BP
$354.00

granuphilin 抗体 (C-3) AC

sc-374544 AC
500 µg/ml, 25% agarose
$416.00

granuphilin 抗体 (C-3) HRP

sc-374544 HRP
200 µg/ml
$316.00

granuphilin 抗体 (C-3) FITC

sc-374544 FITC
200 µg/ml
$330.00

granuphilin 抗体 (C-3) PE

sc-374544 PE
200 µg/ml
$343.00

granuphilin 抗体 (C-3) Alexa Fluor® 488

sc-374544 AF488
200 µg/ml
$357.00

granuphilin 抗体 (C-3) Alexa Fluor® 546

sc-374544 AF546
200 µg/ml
$357.00

granuphilin 抗体 (C-3) Alexa Fluor® 594

sc-374544 AF594
200 µg/ml
$357.00

granuphilin 抗体 (C-3) Alexa Fluor® 647

sc-374544 AF647
200 µg/ml
$357.00

granuphilin 抗体 (C-3) Alexa Fluor® 680

sc-374544 AF680
200 µg/ml
$357.00

granuphilin 抗体 (C-3) Alexa Fluor® 790

sc-374544 AF790
200 µg/ml
$357.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with granuphilin (C-3): sc-374544?

Asked by: jerojero
We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Excellent antibodyI bought this as a free sample and it works good for western
Date published: 2022-09-02
Rated 5 out of 5 by from Great Western blot data of granuphilin expressionGreat Western blot data of granuphilin expression in non-transfected and human granuphilin transfected 293 whole cell lysates. -SCBT QC
Date published: 2013-05-24
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granuphilin 抗体 (C-3) is rated 5.0 out of 5 by 2.
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