Date published: 2026-10-17

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GR/NR3C1/Glucocorticoid Receptor 抗体 (A-4): sc-376425

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说明书
  • GR/NR3C1/Glucocorticoid Receptor抗体(A-4)是小鼠单克隆IgG2b κ, 在3篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于mouse物种的GR α的N-terminus的氨基酸5-33之间
  • 推荐用于 mouse 和 rat 来源的GR α and GR β WB, IP, IF 和 ELISA检测
  • 可用于ChIP的TransCruz试剂(sc-376425 X, 200 µg/0.1 ml)
  • 看 GR/NR3C1/Glucocorticoid Receptor (G-5): sc-393232,可查看有标记的 GR/NR3C1/Glucocorticoid Receptor 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP是GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与GR/NR3C1/Glucocorticoid Receptor Antibody (A-4) 打包提供(请参阅下面的订购信息)。
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関連項目

糖皮质激素受体(GR)是一种普遍表达的转录因子,可以调节糖皮质激素的作用。最丰富的亚型是GRα。GR诱导或抑制基因表达以响应糖皮质激素,介导细胞凋亡、细胞生长和分化等过程。GR抑制的一类重要基因由转录因子AP-1控制。GR也被证明是糖皮质激素诱导基因表达的限制因素。已经发现GR与HSP 90形成复合物,使非配体结合受体在转录上失活。更重要的是,缺乏信号传导域的突变GR保持组成型活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

GR/NR3C1/Glucocorticoid Receptor 抗体 (A-4) 参考文献:

  1. 糖皮质激素受体在乳腺癌中的信号传导。  |  Moutsatsou, P. and Papavassiliou, AG. 2008. J Cell Mol Med. 12: 145-63. PMID: 18053085
  2. 人类呼吸道上皮细胞中的糖皮质激素受体。  |  Pujolsa, L., et al. 2009. Neuroimmunomodulation. 16: 290-9. PMID: 19571590
  3. 使用选择性糖皮质激素受体调节剂靶向炎症。  |  De Bosscher, K., et al. 2010. Curr Opin Pharmacol. 10: 497-504. PMID: 20493772
  4. 糖皮质激素受体在骨骼肌中的代谢功能。  |  Kuo, T., et al. 2013. Mol Cell Endocrinol. 380: 79-88. PMID: 23523565
  5. 糖皮质激素受体改变等容收缩并抑制心脏纤维化。  |  Richardson, RV., et al. 2017. J Endocrinol. 232: 437-450. PMID: 28057868
  6. 天然和合成化合物作为糖皮质激素受体的解离性激动剂。  |  Zhang, T., et al. 2020. Pharmacol Res. 156: 104802. PMID: 32278042
  7. 内皮细胞糖皮质激素受体的丧失会加速糖尿病肾病的发展。  |  Srivastava, SP., et al. 2021. Nat Commun. 12: 2368. PMID: 33888696
  8. 糖皮质激素受体调节剂relacorilant可逆转皮质醇的免疫抑制作用。  |  Greenstein, AE. and Hunt, HJ. 2023. Int Immunopharmacol. 120: 110312. PMID: 37230031
  9. 糖皮质激素受体复合物的激活。  |  Schmidt, TJ., et al. 1982. J Cell Biochem. 20: 15-27. PMID: 6761347
  10. 糖皮质激素受体的结构和功能。  |  Wright, AP., et al. 1993. J Steroid Biochem Mol Biol. 47: 11-9. PMID: 8274424

订购信息

产品名称产品编号规格价格数量收藏夹

GR/NR3C1/Glucocorticoid Receptor 抗体 (A-4)

sc-376425
200 µg/ml
$322.00

GR/NR3C1/Glucocorticoid Receptor (A-4): m-IgG2b BP-HRP 套装

sc-548597
200 µg Ab; 10 µg BP
$361.00

GR/NR3C1/Glucocorticoid Receptor (A-4) 中和勝肽

sc-376425 P
100 µg/0.5 ml
$69.00

GR/NR3C1/Glucocorticoid Receptor 抗体 (A-4) X

sc-376425 X
200 µg/0.1 ml
$322.00

What application is the blocking peptide sc-376425 P appropriate for?

Asked by: Professor Griffin
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 3 out of 5 by dayanknox from Does not work in brain homogenatesSCBT had the best antibody for GR in brain tissue. Since it was discontinued it has been quite problematic finding a replacement. Unfortunately this antibody does not work in brain homogenates
Date published: 2017-11-17
Rated 5 out of 5 by SF from Worked well for Western with NIH/3T3 nuclearWorked well for Western with NIH/3T3 nuclear extract. -SCBT QC
Date published: 2014-02-12
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GR/NR3C1/Glucocorticoid Receptor 抗体 (A-4) is rated 4.0 out of 5 by 2.
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