Glycophorin A Antibody (5G119): sc-71159

Glycophorin A Antibody (5G119) is a mouse monoclonal IgG1 antibody that detects Glycophorin A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Glycophorin A is a crucial sialoglycoprotein located in the human erythrocyte membrane, where Glycophorin A plays a significant role in maintaining the structural integrity of red blood cells and facilitating cell-cell interactions. Glycophorin A spans the membrane once, with its amino-terminal end exposed to the extracellular environment, which is essential for defining blood group phenotypes through antigenic determinants. The Glycophorin A gene, located on chromosome 4q31.21, consists of seven exons and encodes a 150 amino acid protein that is 97% homologous to Glycophorin B. The presence of Glycophorin A on the erythrocyte surface is vital for preventing hemolysis and ensuring proper blood transfusion compatibility, making Glycophorin A an important target for studies related to blood group antigens and transfusion medicine. Anti-Glycophorin A antibody (5G119) is an invaluable tool for researchers investigating erythrocyte biology and blood group antigen expression.

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Glycophorin A Antibody (5G119) References:

1. Influence of the C-terminus of the glycophorin A transmembrane fragment on the dimerization process.  |  Orzáez, M., et al. 2000. Protein Sci. 9: 1246-53. PMID: 10892817
2. Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane.  |  Sánchez, G., et al. 2004. J Virol. 78: 9807-13. PMID: 15331714
3. Terminal sialic acid residues on human glycophorin A are recognized by porcine kupffer cells.  |  Burlak, C., et al. 2005. Transplantation. 80: 344-52. PMID: 16082330
4. Production of human anti-glycophorin-A monoclonal antibodies and their purification by pseudoaffinity chromatography using a convective interaction media monolithic column.  |  Kumar, BP., et al. 2012. Hybridoma (Larchmt). 31: 105-10. PMID: 22509914
5. The Mz variety of the St(a+) phenotype--a variant of glycophorin A exhibiting a deletion.  |  Dahr, W., et al. 1990. Biol Chem Hoppe Seyler. 371: 403-10. PMID: 2378678
6. Brown Recluse spider bite mediated hemolysis: clinical features, a possible role for complement inhibitor therapy, and reduced RBC surface glycophorin A as a potential biomarker of venom exposure.  |  Gehrie, EA., et al. 2013. PLoS One. 8: e76558. PMID: 24086749
7. Nanoparticle Attachment to Erythrocyte Via the Glycophorin A Targeted ERY1 Ligand Enhances Binding without Impacting Cellular Function.  |  Sahoo, K., et al. 2016. Pharm Res. 33: 1191-203. PMID: 26812966
8. A new antigen SUMI carried on glycophorin A encoded by the GYPA*M with c.91A>C (p.Thr31Pro) belongs to the MNS blood group system.  |  Ito, S., et al. 2020. Transfusion. 60: 1287-1293. PMID: 32358867
9. Glycophorin A-based exclusion of red blood cells for flow cytometric analysis of platelet glycoprotein expression in citrated whole blood.  |  Berens, C., et al. 2020. Clin Chem Lab Med. 58: 2081-2087. PMID: 32598296
10. Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator.  |  Langosch, D., et al. 1996. J Mol Biol. 263: 525-30. PMID: 8918935

The preferred Glycophorin A antibody is Glycophorin A Antibody (R10): sc-53905.