GIOT-2 Antibody (H-1): sc-398496
- GIOT-2 Antibody (H-1) is a mouse monoclonal IgG2a κ GIOT-2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 20-45 near the N-terminus of GIOT-2 of human origin
- GIOT-2 Antibody (H-1) is recommended for detection of GIOT-2 of human origin by WB, IP, IF and ELISA
- Anti-GIOT-2 Antibody (H-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GIOT-2 Antibody (H-1) for WB applications. These reagents are now offered in bundles with GIOT-2 Antibody (H-1) (see ordering information below).
GIOT-2 Antibody (H-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects GIOT-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIOT-2 (H-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GIOT-2 protein, also known as Gonadotropin-inducible transcription repressor 2, ZNF44, or KOX7, is a 589 amino acid member of the Krüppel C2H2-type zinc-finger family, characterized by 16 C2H2-type zinc fingers and a KRAB domain. This nuclear protein plays a crucial role in transcriptional regulation, particularly in the repression of gonadotropin gene expression, which is vital for maintaining reproductive hormone balance. The presence of the KRAB domain is significant as KRAB interacts with KAP1, facilitating the recruitment of histone-modifying proteins that further influence gene expression. Using anti-GIOT-2 antibody (H-1) in research can provide insights into the regulatory mechanisms of gonadotropin expression and the broader implications for reproductive health.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GIOT-2 Antibody (H-1) References:
- Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells. | Li, Z., et al. 2005. Environ Health Perspect. 113: 1747-54. PMID: 16330358
- A cluster of expressed zinc finger protein genes in the pericentromeric region of human chromosome 10. | Rousseau-Merck, MF., et al. 1992. Genomics. 13: 845-8. PMID: 1639412
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. | Olsen, JV., et al. 2006. Cell. 127: 635-48. PMID: 17081983
- Chemopreventive agents alters global gene expression pattern: predicting their mode of action and targets. | Narayanan, BA. 2006. Curr Cancer Drug Targets. 6: 711-27. PMID: 17168675
- Characterization and mapping of human genes encoding zinc finger proteins. | Bray, P., et al. 1991. Proc Natl Acad Sci U S A. 88: 9563-7. PMID: 1946370
- Use of integrative epigenetic and cytogenetic analyses to identify novel tumor-suppressor genes in malignant melanoma. | Mithani, SK., et al. 2011. Melanoma Res. 21: 298-307. PMID: 21606880
- Myoepithelioma of bone with a novel FUS-POU5F1 fusion gene. | Puls, F., et al. 2014. Histopathology. 65: 917-22. PMID: 25066216
- Somatic mutations in specific and connected subpathways are associated with short neuroblastoma patients' survival and indicate proteins targetable at onset of disease. | Esposito, MR., et al. 2018. Int J Cancer. 143: 2525-2536. PMID: 29992558
- RNA-Sequencing Combined With Genome-Wide Allele-Specific Expression Patterning Identifies ZNF44 Variants as a Potential New Driver Gene for Pediatric Neuroblastoma. | Sun, L., et al. 2023. Cancer Control. 30: 10732748231175017. PMID: 37161925
- An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. | Perkins, ND., et al. 1994. Mol Cell Biol. 14: 6570-83. PMID: 7935378
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GIOT-2 Antibody (H-1) | sc-398496 | 200 µg/ml | $322.00 | |||
GIOT-2 Antibody (H-1): m-IgG Fc BP-HRP Bundle | sc-530820 | 200 µg Ab; 10 µg BP | $361.00 | |||
GIOT-2 Antibody (H-1): m-IgGκ BP-HRP Bundle | sc-524366 | 200 µg Ab, 40 µg BP | $361.00 | |||
GIOT-2 Antibody (H-1): m-IgG2a BP-HRP Bundle | sc-547600 | 200 µg Ab; 10 µg BP | $361.00 | |||
GIOT-2 Antibody (H-1) AC | sc-398496 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GIOT-2 Antibody (H-1) HRP | sc-398496 HRP | 200 µg/ml | $322.00 | |||
GIOT-2 Antibody (H-1) FITC | sc-398496 FITC | 200 µg/ml | $336.00 | |||
GIOT-2 Antibody (H-1) PE | sc-398496 PE | 200 µg/ml | $349.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 488 | sc-398496 AF488 | 200 µg/ml | $364.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 546 | sc-398496 AF546 | 200 µg/ml | $364.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 594 | sc-398496 AF594 | 200 µg/ml | $364.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 647 | sc-398496 AF647 | 200 µg/ml | $364.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 680 | sc-398496 AF680 | 200 µg/ml | $364.00 | |||
GIOT-2 Antibody (H-1) Alexa Fluor® 790 | sc-398496 AF790 | 200 µg/ml | $364.00 | |||
GIOT-2 (H-1) Neutralizing Peptide | sc-398496 P | 100 µg/0.5 ml | $69.00 |