GHR Antibody (B-12): sc-137184

GHR Antibody (B-12) is a mouse monoclonal IgG2a antibody that detects growth hormone receptor (GHR) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GHR antibody (B-12) plays a crucial role in understanding the function of GHR, which is essential for mediating the effects of growth hormone (GH) produced by the anterior pituitary gland. This receptor is integral to various metabolic processes and body growth regulation. GHR is located in the cell membrane, where GHR interacts with GH, triggering a cascade of intracellular signaling pathways that promote growth and metabolic functions. Importantly, GHR also exists in a soluble form, known as GH-binding protein (GHBP), which is produced through the proteolytic cleavage of its extracellular domain. The presence of GHBP is significant as reduced levels are linked to growth hormone insensitivity syndrome, highlighting the importance of GHR in both normal physiology and disease states. GHR monoclonal antibody (B-12) is a valuable tool for researchers investigating the complexities of growth hormone signaling and its implications in various biological processes.

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GHR Antibody (B-12) References:

1. The growth hormone receptor (GHR) polymorphism in growth-retarded children with Cushing disease: lack of association with growth and measures of the somatotropic axis.  |  Drori-Herishanu, L., et al. 2010. Horm Metab Res. 42: 194-7. PMID: 20013551
2. Targeted loss of GHR signaling in mouse skeletal muscle protects against high-fat diet-induced metabolic deterioration.  |  Vijayakumar, A., et al. 2012. Diabetes. 61: 94-103. PMID: 22187377
3. Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA).  |  Wan, J., et al. 2013. J Clin Endocrinol Metab. 98: E77-81. PMID: 23162096
4. Influence of growth hormone receptor (GHR) exon 3 and -202A/C IGFBP-3 genetic polymorphisms on clinical and biochemical features and therapeutic outcome of patients with acromegaly.  |  Jallad, RS., et al. 2015. Pituitary. 18: 666-73. PMID: 25552351
5. Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.  |  List, EO., et al. 2015. Aging (Albany NY). 7: 500-12. PMID: 26233957
6. The exon3-deleted growth hormone receptor gene polymorphism (d3-GHR) is associated with insulin and spontaneous growth in short SGA children (NESGAS).  |  Wegmann, MG., et al. 2017. Growth Horm IGF Res. 35: 45-51. PMID: 28719834
7. Serum leptin levels and GHR-d3/fl gene polymorphism in acromegalic patients with thyroid nodules.  |  Topsakal, S., et al. 2017. Adv Clin Exp Med. 26: 281-286. PMID: 28791847
8. Growth hormone promotes human endometrial glandular cells proliferation and motion through the GHR-STAT3/5 pathway.  |  Feng, Q., et al. 2020. Ann Transl Med. 8: 53. PMID: 32175347
9. A common deletion in the growth hormone receptor gene (d3-GHR) in the offspring is related to maternal placental GH levels during pregnancy.  |  Jensen, RB., et al. 2020. Growth Horm IGF Res. 55: 101360. PMID: 33096343
10. Regulation of extracellular and intracellular prolactin on cell proliferation and survival rate through GHR/JAK2/STAT3 pathway in NSCLC.  |  Chou, JC., et al. 2021. Chemosphere. 264: 128604. PMID: 33268090

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.