Date published: 2025-9-8

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Gephyrin 抗体 (45): sc-135920

4.7(3)
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说明书
  • Gephyrin 抗体 45 是小鼠单克隆 IgG1, 在1篇文献中引用,提供 50 µg/0.5 ml
  • 免疫rat物种的Gephyrin的氨基酸569-726
  • 推荐用于 mouse, rat, human 和 Drosophila 来源的Gephyrin WB, IP, IF 和 IHC(P)检测
  • 目前,我们还没有完成Gephyrin 抗体 (45)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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突触后膜的亚膜区含有许多对受体靶向至关重要的蛋白质。Gephyrin是一种微管相关蛋白,在脑中高度表达,并定位于神经元突触后膜。Gephyrin对于抑制性甘氨酸受体的突触后定位至关重要,被认为是将受体锚定到突触下微管。该蛋白在大多数哺乳动物组织中表达,主要在脑中表达。在大鼠和人脑组织中,已经鉴定出至少五个分子量不同的Gephyrin剪接变异体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Gephyrin 抗体 (45) 参考文献:

  1. 突触和突触外的GABAA受体和gephyrin簇。  |  Christie, SB., et al. 2002. Prog Brain Res. 136: 157-80. PMID: 12143379
  2. 多价调节gephyrin-甘氨酸受体亲和力。  |  Maric, HM., et al. 2014. ACS Chem Biol. 9: 2554-62. PMID: 25137389
  3. Gephyrin结合肽可显示突触后部位并调节神经传递。  |  Maric, HM., et al. 2017. Nat Chem Biol. 13: 153-160. PMID: 27893705
  4. Gephyrin通过降低mTOR途径的激活来抑制肺鳞状细胞癌的发展。  |  Zhang, X., et al. 2019. Cancer Manag Res. 11: 5333-5341. PMID: 31239782
  5. 通过相分离,gephyrin介导抑制性突触后密度板的形成。  |  Bai, G., et al. 2021. Cell Res. 31: 312-325. PMID: 33139925
  6. 高阶gephyrin寡聚体的形成受损是gephyrin功能障碍相关病理的基础。  |  Kim, S., et al. 2021. iScience. 24: 102037. PMID: 33532714
  7. 抑制性突触中甘氨酸受体和gephyrin支架蛋白的相互稳定。  |  Chapdelaine, T., et al. 2021. Biophys J. 120: 805-817. PMID: 33539789
  8. 基于DARPin的分子工具集可用于研究gephyrin和抑制性突触生物学。  |  Campbell, BFN., et al. 2022. Elife. 11: PMID: 36314779
  9. gephyrin支架可调节皮层2/3锥体神经元对单根触须刺激的响应。  |  Tsai, YC., et al. 2024. Sci Rep. 14: 4169. PMID: 38379020
  10. miRNA介导的gephyrin合成控制可驱动持续抑制突触可塑性。  |  Welle, TM., et al. 2024. EMBO Rep. 25: 5141-5168. PMID: 39294503

订购信息

产品名称产品编号规格价格数量收藏夹

Gephyrin 抗体 (45)

sc-135920
50 µg/0.5 ml
$316.00

Can sc-135920: Gephyrin (45) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: AbPolly
Thank you for your question. Yes, sc-135920: Gephyrin (45) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Sensitive and specificAntibody used for Western blotting at 1:200. Results gave a single, clear band at the expected weight, even after reusing the antibody several times (storing the diluted Ab at -20C).
Date published: 2020-06-15
Rated 5 out of 5 by from Clean blot with single strong band at expectedClean blot with single strong band at expected size using rat brain tissue extract. -SCBT QC
Date published: 2015-03-03
Rated 4 out of 5 by from Robust immunoperoxidase cytoplasmic stainingRobust immunoperoxidase cytoplasmic staining in formalin-fixed, paraffin-embedded rat cerebellum tissue. -SCBT QC
Date published: 2013-01-06
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Gephyrin 抗体 (45) is rated 4.7 out of 5 by 3.
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