Date published: 2025-9-8
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γ-catenin Antibody (H-1) - Western Blotting - Image 355671
γ-catenin 抗体 (H-1): sc-8415. Western 印迹分析 MCF7 全细胞裂解液中 γ-catenin 的表达.
γ-catenin 抗体 (H-1): sc-8415. Western 印迹分析 MCF7 全细胞裂解液中 γ-catenin 的表达.

γ-catenin 抗体 (H-1): sc-8415

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说明书
  • γ-catenin抗体(H-1)是小鼠单克隆IgG1 κ, 在18篇文献中引用，规格为200 µg/ml
  • 免疫human来源γ-catenin近N-terminus的30-109氨基酸
  • 推荐用于 human 来源的γ-catenin WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 γ-catenin 抗体 (H-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与γ-catenin 抗体 (H-1) 组合成套装提供。 (请参阅下面的订购信息)。

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基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Catenin 抗体 包括 α E-catenin, α T-catenin, β-catenin, δ-catenin和γ-catenin

γ-catenin抗体（H-1）是一种小鼠单克隆IgG1抗体，可通过多种应用检测人类样本中的γ-catenin，包括蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和酶联免疫吸附测定（ELISA）。γ-catenin，也称为斑块蛋白，通过与E-cadherin和N-cadherin等钙粘蛋白形成复合物，在细胞粘附中发挥关键作用，这些钙粘蛋白对于维持组织的完整性和结构至关重要。γ-catenin主要位于细胞质和细胞膜中，与钙粘蛋白的细胞质尾部相互作用，促进细胞骨架与细胞粘附分子之间的连接。这种定位确保了细胞之间能够有效地沟通和粘附，这对于组织发育和修复等过程至关重要。此外，γ-catenin还参与调节细胞增殖和分化的信号通路，使其成为正常生理和疾病状态（包括癌症）中的重要参与者。抗-γ-catenin抗体（H-1）是研究人员研究细胞粘附动力学和各种细胞过程分子机制的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

γ-catenin 抗体 (H-1) 参考文献:

  1. γ-catenin/CBP复合物可维持β-catenin缺陷/缺失癌细胞中存活素的转录。  |  Kim, YM., et al. 2011. Curr Cancer Drug Targets. 11: 213-25. PMID: 21158719
  2. 下调的γ-catenin表达与食管癌的肿瘤侵袭性有关。  |  Fang, WK., et al. 2014. World J Gastroenterol. 20: 5839-48. PMID: 24914344
  3. γ-catenin在急性髓性白血病中的临床意义。  |  Xu, J., et al. 2016. Onco Targets Ther. 9: 3861-71. PMID: 27390526
  4. γ-Catenin 通过上下文依赖机制在结直肠癌中发挥抑癌作用。  |  Nagel, JM., et al. 2017. Int J Colorectal Dis. 32: 1243-1251. PMID: 28681073
  5. BCR-ABL1+B细胞急性淋巴细胞白血病的γ-Catenin依赖性信号。  |  Luong-Gardiol, N., et al. 2019. Cancer Cell. 35: 649-663.e10. PMID: 30991025
  6. γ-catenin通过抑制GSK-3β的磷酸化减轻心脏纤维化。  |  Tang, X., et al. 2019. J Biomed Res. 0: 1-9. PMID: 31741464
  7. T淋巴细胞和急性髓细胞性白血病干细胞不需要β-catenin和γ-catenin。  |  Zhao, X., et al. 2020. Elife. 9: PMID: 32820720
  8. miR-195-5p是结直肠癌中γ-Catenin和Desmosome连接的调控因子  |  Piccinno, E., et al. 2023. Int J Mol Sci. 24: PMID: 38069408
  9. miR-195-5p 下调γ-Catenin 可抑制结肠癌进展，调节脱膜体功能。  |  Piccinno, E., et al. 2023. Int J Mol Sci. 25: PMID: 38203664
  10. 鉴定α-catenin与β-catenin和plakoglobin（γ-catenin）关联的结构域。  |  Obama, H. and Ozawa, M. 1997. J Biol Chem. 272: 11017-20. PMID: 9110993

订购信息

产品名称产品编号规格价格数量收藏夹

γ-catenin 抗体 (H-1)

sc-8415
200 µg/ml
$316.00

γ-catenin (H-1): m-IgG Fc BP-HRP 套装

sc-538893
200 µg Ab; 10 µg BP
$354.00

γ-catenin (H-1): m-IgG1 BP-HRP 套装

sc-541128
200 µg Ab; 20 µg BP
$354.00

Can γ-catenin (H-1): sc-8415 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Randy McDonald
Thank you for your question. Yes, γ-catenin (H-1): sc-8415 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Publishable IP/WB results in human HN5 samplesPublishable IP/WB results in human HN5 samples. -SCBT Publication Review
Date published: 2015-04-24
Rated 5 out of 5 by from Successful western blot detection ofSuccessful western blot detection of -catenin expression in HeLa and A-431 whole cell lysates. -SCBT QC
Date published: 2015-04-22
Rated 5 out of 5 by from Worked well in immunofluorescence stainingWorked well in immunofluorescence staining of methanol-fixed HeLa cells, showing membrane and cell junction localization. -SCBT QC
Date published: 2015-04-18
Rated 5 out of 5 by from IHC(P) and IF data published in human pancreasIHC(P) and IF data published in human pancreas samples. -SCBT Publication Review
Date published: 2015-04-09
Rated 5 out of 5 by from Positive immunoperoxidase staining of formalinPositive immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma showed membrane localization -SCBT QC
Date published: 2013-07-11
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γ-catenin 抗体 (H-1) is rated 5.0 out of 5 by 5.
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