Date published: 2025-9-9
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Fyn Antibody (15) - Western Blotting - Image 352720
Fyn 抗体 (15): sc-434. Western 印迹分析 Ramos 全细胞裂解液中 Fyn 的表达.
Fyn 抗体 (15): sc-434. Western 印迹分析 Ramos 全细胞裂解液中 Fyn 的表达.

Fyn 抗体 (15): sc-434

4.3(19)
寫評論提問

说明书
  • Fyn 抗体 15 是小鼠单克隆 IgG1 κ，Fyn抗体, 在146篇文献中引用，规格为200 µg/ml
  • human Fyn 85-206的氨基酸之间的表位图谱
  • Fyn 抗体 (15) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 Fyn p59
  • 抗Fyn抗体（15）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Fyn (15): sc-434的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Fyn 抗体 (15) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Fyn 抗体 (15) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

Fyn抗体（15）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、免疫组织化学和流式细胞术（FCM）检测小鼠、大鼠和人类来源的Fyn蛋白。Fyn (15) 单克隆抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。Fyn是Src家族非受体酪氨酸激酶的成员，在T细胞受体信号传导中起着至关重要的作用，而T细胞受体信号传导对于免疫反应至关重要。Fyn主要位于细胞质中，激活后可转移到细胞膜上，与各种信号分子相互作用，从而调节细胞增殖、分化、运动等过程。Fyn的适当定位对于其功能至关重要，因为这样可以精确调节信号通路，而信号通路对于T细胞活化和免疫反应至关重要。人类Fyn基因位于6q21染色体上，编码一种537个氨基酸的蛋白质，通过激酶活性参与调节各种细胞功能。了解Fyn的作用及其在细胞内的定位，有助于深入了解其对免疫系统调节的作用，以及其在癌症和自身免疫性疾病等疾病中的潜在影响。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Fyn 抗体 (15) 参考文献:

  1. Src 家族激酶：结构与功能。  |  Tatosyan, AG. and Mizenina, OA. 2000. Biochemistry (Mosc). 65: 49-58. PMID: 10702640
  2. 白细胞中 Src 激酶介导的信号传导。  |  Korade-Mirnics, Z. and Corey, SJ. 2000. J Leukoc Biol. 68: 603-13. PMID: 11073097
  3. Src 激酶活化和功能的精选一瞥。  |  Bjorge, JD., et al. 2000. Oncogene. 19: 5620-35. PMID: 11114743
  4. SRC家族激酶介导内皮素对上皮Na+通道的抑制作用  |  Gilmore, ES., et al. 2001. J Biol Chem. 276: 42610-7. PMID: 11560932
  5. Fyn在神经发育和缺血性脑损伤中的作用。  |  Knox, R. and Jiang, X. 2015. Dev Neurosci. 37: 311-20. PMID: 25720756
  6. 阿尔茨海默病中的Fyn激酶靶向。  |  Nygaard, HB. 2018. Biol Psychiatry. 83: 369-376. PMID: 28709498
  7. Fyn在帕金森氏病中放大NLRP3炎症小体信号。  |  Panicker, N., et al. 2019. Aging (Albany NY). 11: 5871-5873. PMID: 31454793
  8. FYN：癌症中新的生物学作用和潜在的治疗靶点。  |  Peng, S. and Fu, Y. 2023. J Transl Med. 21: 84. PMID: 36740671
  9. FYN/TOPK/HSPB1轴促进胃癌的增殖和转移。  |  Peng, S., et al. 2023. J Exp Clin Cancer Res. 42: 80. PMID: 37016377
  10. Lyn，一种类 src 酪氨酸激酶。  |  Hibbs, ML. and Dunn, AR. 1997. Int J Biochem Cell Biol. 29: 397-400. PMID: 9202419
  11. 深入了解 Src 激酶的功能：结构比较。  |  Williams, JC., et al. 1998. Trends Biochem Sci. 23: 179-84. PMID: 9612082

订购信息

产品名称产品编号规格价格数量收藏夹

Fyn 抗体 (15)

sc-434
200 µg/ml
$316.00

Fyn (15): m-IgG Fc BP-HRP 套装

sc-528110
200 µg Ab; 10 µg BP
$354.00

Fyn (15): m-IgGκ BP-HRP 套装

sc-520409
200 µg Ab, 40 µg BP
$354.00

Fyn (15): m-IgG1 BP-HRP 套装

sc-542764
200 µg Ab; 20 µg BP
$354.00

Fyn 抗体 (15) AC

sc-434 AC
500 µg/ml, 25% agarose
$416.00

Fyn 抗体 (15) HRP

sc-434 HRP
200 µg/ml
$316.00

Fyn 抗体 (15) FITC

sc-434 FITC
200 µg/ml
$330.00

Fyn 抗体 (15) PE

sc-434 PE
200 µg/ml
$343.00

Fyn 抗体 (15) Alexa Fluor® 488

sc-434 AF488
200 µg/ml
$357.00

Fyn 抗体 (15) Alexa Fluor® 546

sc-434 AF546
200 µg/ml
$357.00

Fyn 抗体 (15) Alexa Fluor® 594

sc-434 AF594
200 µg/ml
$357.00

Fyn 抗体 (15) Alexa Fluor® 647

sc-434 AF647
200 µg/ml
$357.00

Fyn 抗体 (15) Alexa Fluor® 680

sc-434 AF680
200 µg/ml
$357.00

Fyn 抗体 (15) Alexa Fluor® 790

sc-434 AF790
200 µg/ml
$357.00

Which is the best antibody for immunoprecipitation of human FYN protein? Can you please show a reference? Thanks - 

Asked by: mark_g
Thank you very much for your question. Currently, we would recommend using our Fyn Antibody (15) sc-434 for the Immunoprecipitation of the human FYN protein. You might want to follow the link to get a list of the currently available 28 product citations referring to the use of sc-434 in IP. Just enter the catalogue number and select the desired application from the drop down list. https://www.scbt.com/scbt/misc/citationSearch.jsp
Answered by: Technical Support Europe
Date published: 2018-01-16

What is the appropriate negative control for this antibody in flow cytometry?

Asked by: AbPolly
Thank you for your question. You would want to use a normal mouse IgG1 as a negative control in flow cytometry. If the primary antibody is conjugated, for example to PE, then you would use the normal conjugate, such as normal mouse IgG1 PE.
Answered by: Technical Support 7
Date published: 2019-11-13

Does this antibody cross react with Src or other related genes?

Asked by: AbPolly
Thank you for your question. We do not guarantee this antibody for detection of Src. For alignments and homology with other gene targets, please contact our Technical Service Department.
Answered by: Technical Support 7
Date published: 2017-01-11
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Rated 5 out of 5 by from 抗体很好，条带很清楚我一个月前购买了此产品，并为此感到荣幸，抗体特异性很好，条带也很清楚，并没有看到杂带，在这期间也试过其他家的抗体，sante curz的抗体完全就是其他家不能比拟的，这次购买过程很开心，希望客服能在线，先在是下午4点所有的客服都不在线
Date published: 2018-03-15
Rated 4 out of 5 by from western blotvery good, tested for western blot in murine brains. Detects a band with low background at 60kDa
Date published: 2018-02-08
Rated 4 out of 5 by from This antibody is ok.the band is clear in some of L929 cells, but can not detets in other L929 cells which from the same original. This is very strang~
Date published: 2017-10-27
Rated 5 out of 5 by from get the desired resultsFyn antibody, which particularly and well suited for WB, 1/800 dilution showed a specific band at 59kda.
Date published: 2017-10-19
Rated 5 out of 5 by from specific/sharp bands detectedThis antibody was tested on human aortic endothelial cells post various treatments. It gives specific band with no background.
Date published: 2017-09-14
Rated 5 out of 5 by from Good antibody for IP WBI used this antibody for my IP WB on human samples, and it gave me strong band
Date published: 2017-03-30
Rated 5 out of 5 by from very goodGreat antibody from santa,completely validated in used in Western Blot,the antibody is very good and the bands are clear.
Date published: 2017-02-24
Rated 5 out of 5 by from Excellent Fyn antibodyGreat detection in flow cytometry, western blot, and IHC/IF. Very well published antibody with strong data in mouse, rat, and human samples.
Date published: 2017-01-23
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Fyn 抗体 (15) is rated 4.3 out of 5 by 19.
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