Date published: 2025-9-9

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FREM2 抗体 (F-1): sc-376555

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说明书
  • FREM2 抗体 F-1 是小鼠单克隆 IgG1 κ,FREM2抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列2281-2580位于human物种的FREM2的内部区域内
  • FREM2 抗体 (F-1) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 FREM2
  • 抗FREM2抗体(F-1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 另提供生物素偶联抗体,可用于WB、IHC(P)和ELISA实验
  • 关于如何获取FREM2 (F-1): sc-376555免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgGκ BP-HRP是FREM2 Antibody (F-1) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与FREM2 Antibody (F-1) 搭配使用(请参阅下面的订购信息)。有关其它 m-IgGκ BP 结合物,请参阅我们完整的小鼠 IgG 结合蛋白列表。

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関連項目

FREM2 抗体 (F-1) 是一种小鼠单克隆 IgG1 kappa 轻链抗体,可通过免疫印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和酶联免疫吸附 (ELISA) 检测小鼠、大鼠和人源的 FREM2 蛋白。FREM2(F-1)抗体有非共轭型和多种共轭型,包括琼脂糖、生物素、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种 Alexa Fluor® 共轭物。FREM2 蛋白又称 FRAS1 相关细胞外基质蛋白 2,是一种 3,169 氨基酸的单通道 I 型膜蛋白,主要位于细胞膜的细胞外侧。这种定位使 FREM2 能够在细胞外基质中发挥重要作用,而细胞外基质对于维持组织结构的完整性至关重要,尤其是在皮肤和肾上皮中。FREM2 参与表皮粘附活动,这对皮肤的正常功能和伤口愈合至关重要。位于人类第 13 号染色体上的 FREM2 编码基因发生突变会导致弗雷泽综合征,这是一种多系统畸形,其特征是各种发育异常,包括耳朵缺陷和先天性心脏问题。此外,FREM2 存在多种交替剪接异构体,可能在细胞过程中发挥不同的功能作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

FREM2 抗体 (F-1) 参考文献:

  1. 细胞外基质基因 Frem1 对胚胎表皮的正常粘附至关重要。  |  Smyth, I., et al. 2004. Proc Natl Acad Sci U S A. 101: 13560-5. PMID: 15345741
  2. 鉴定出一种在弗雷泽综合征和小鼠骨髓脑白斑中发生突变的新基因。  |  Jadeja, S., et al. 2005. Nat Genet. 37: 520-5. PMID: 15838507
  3. 组织形态发生和血管稳定性需要小鼠骨髓脑出血点基因的产物 Frem2 蛋白。  |  Timmer, JR., et al. 2005. Proc Natl Acad Sci U S A. 102: 11746-50. PMID: 16087869
  4. QBRICK/Frem1, Fras1和Frem2在基底膜上的相互稳定作用被破坏会导致类似弗雷泽综合征的缺陷。  |  Kiyozumi, D., et al. 2006. Proc Natl Acad Sci U S A. 103: 11981-6. PMID: 16880404
  5. 弗雷泽综合症是由于 FREM2 的剪接位点突变导致的同基因遗传。  |  Shafeghati, Y., et al. 2008. Am J Med Genet A. 146A: 529-31. PMID: 18203166
  6. 33 个弗雷泽综合征家族的分子研究新数据和突变回顾。  |  van Haelst, MM., et al. 2008. Am J Med Genet A. 146A: 2252-7. PMID: 18671281

订购信息

产品名称产品编号规格价格数量收藏夹

FREM2 抗体 (F-1)

sc-376555
200 µg/ml
$316.00

FREM2 (F-1): m-IgGκ BP-HRP 套装

sc-523005
200 µg Ab, 40 µg BP
$354.00

FREM2 抗体 (F-1) AC

sc-376555 AC
500 µg/ml, 25% agarose
$416.00

FREM2 抗体 (F-1) HRP

sc-376555 HRP
200 µg/ml
$316.00

FREM2 抗体 (F-1) FITC

sc-376555 FITC
200 µg/ml
$330.00

FREM2 抗体 (F-1) PE

sc-376555 PE
200 µg/ml
$343.00

FREM2 抗体 (F-1) Alexa Fluor® 488

sc-376555 AF488
200 µg/ml
$357.00

FREM2 抗体 (F-1) Alexa Fluor® 546

sc-376555 AF546
200 µg/ml
$357.00

FREM2 抗体 (F-1) Alexa Fluor® 594

sc-376555 AF594
200 µg/ml
$357.00

FREM2 抗体 (F-1) Alexa Fluor® 647

sc-376555 AF647
200 µg/ml
$357.00

FREM2 抗体 (F-1) Alexa Fluor® 680

sc-376555 AF680
200 µg/ml
$357.00

FREM2 抗体 (F-1) Alexa Fluor® 790

sc-376555 AF790
200 µg/ml
$357.00

FREM2 抗体 (F-1) B

sc-376555 B
200 µg/ml
$320.00

is the uncojugated version of the FREM2 antibody free of azide, serum components, and other NH₂-containing molecules?

Asked by: Normann
Thank you for your question. The antibody is supplied in PBS with sodium azide and gelatin. Please contact our technical service team directly if you require the antibody in custom formulation.
Answered by: Tech Support Europe
Date published: 2024-09-17

Does this antibody work well on mouse tissues - are there any background issues because it's a mouse antibody?

Asked by: Carole W
Thank you for your question. Anti-FREM2 Antibody (F-1) is recommended for detection of FREM2 of mouse, rat and human origin by WB, IP, IF and ELISA. Issues with unspecific signals usually only occur in immunohistochemistry when sections still contain traces of blood.
Answered by: Tech Support Europe
Date published: 2021-02-18

I need to use an antibody to detect the protein in samples of avian origin. Do you know if sc-376555: FREM2 (F-1) mouse monoclonal antibody will work?

Asked by: TinTin
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06

This antibody works in my first trial on a tissue IF. Does this antibody has antigen for absorbing negative control?

Asked by: wwxxdd
Thank you for your question. This antibody was raised against a recombinant protein, not a short peptide sequence, so unfortunately it is not possible to design a blocking peptide for this product.
Answered by: Technical Service
Date published: 2017-01-14
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Rated 5 out of 5 by from Produced positive Western blot data of FREM2Produced positive Western blot data of FREM2 expression in C2C12 whole cell lysate. -SCBT QC
Date published: 2013-09-08
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FREM2抗体 (F-1) is rated 5.0 out of 5 by 1.
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