Date published: 2025-9-7

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fractalkine 抗体 (A-9): sc-166200

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说明书
  • fractalkine 抗体 A-9 是小鼠单克隆 IgG3 (kappa轻链),fractalkine抗体,规格为200 µg/ml
  • 免疫human物种的fractalkine的氨基酸25-100
  • 推荐用于 human 来源的fractalkine WB, IP 和 IF检测
  • 关于如何获取fractalkine (A-9): sc-166200免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG3 BP-HRP是fractalkine Antibody (A-9) 适用于 WB 应用。 的首选辅助检测试剂,该试剂现与fractalkine Antibody (A-9) 搭配使用(请参阅下面的订购信息)。

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    関連項目

    Fractalkine 抗体(A-9)是一种 IgG3 κ 鼠单克隆 Fractalkine 抗体(也称为 CX3CL1 抗体、Neurotactin 抗体或 FKN 抗体),可通过 WB、IP 和 IF 检测人源 Fractalkine 蛋白质。Fractalkine 抗体(A-9)为非偶联的抗 Fractalkine 抗体。趋化因子是一类可诱导的、分泌的、促炎细胞因子的超家族成员。趋化因子家族的成员在其预测的氨基酸序列中表现出 20% 到 50% 的同源性,并被分为四个亚家族。在称为 C-C 或 β 的亚家族中,前两个半胱氨酸相邻。在 C-X-C 或 α 亚家族中,四个半胱氨酸残基中的前两个被一个氨基酸隔开。C 亚家族成员,也称为 γ 趋化因子,缺乏保守基序的第一个和第三个半胱氨酸残基。这三个亚家族中的趋化因子都是小的分泌蛋白。Fractalkine,也被称为 Neurotactin,是第四个趋化因子亚家族的第一个被表征的成员。Fractalkine 包含一个新颖的 C-X3-C 基序,其中前两个半胱氨酸被三个氨基酸残基隔开。已在大脑和心脏中检测到 Fractalkine mRNA,并且在炎症信号的刺激下,其在小胶质细胞和内皮细胞中的表达会上调。该蛋白质既以膜结合形式存在,也以趋化性的可溶性形式存在。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    fractalkine 抗体 (A-9) 参考文献:

    1. 趋化因子的生物学和生物化学:趋化和炎症细胞因子家族。  |  Miller, MD. and Krangel, MS. 1992. Crit Rev Immunol. 12: 17-46. PMID: 1418604
    2. 新型促炎超级基因 'intercrine '细胞因子家族的特性。  |  Oppenheim, JJ., et al. 1991. Annu Rev Immunol. 9: 617-48. PMID: 1910690
    3. 阿尔茨海默病中的神经炎症和分叉碱信号传导  |  Finneran, DJ. and Nash, KR. 2019. J Neuroinflammation. 16: 30. PMID: 30744705
    4. 帕金森病中的分叉蛋白(CX3CL1)信号传导和神经炎症:潜在的临床和治疗意义  |  Angelopoulou, E., et al. 2020. Pharmacol Res. 158: 104930. PMID: 32445958
    5. 小神经胶质细胞对有活力的少突胶质细胞祖细胞的修剪调控髓鞘化  |  Nemes-Baran, AD., et al. 2020. Cell Rep. 32: 108047. PMID: 32814050
    6. Fractalkine/CX3CR1 对健康和疾病中突触和网络可塑性的依赖性调控  |  Camacho-Hernández, NP. and Peña-Ortega, F. 2023. Neural Plast. 2023: 4637073. PMID: 36644710
    7. 抗 CX3CL1(fractalkine)单克隆抗体可减轻硬皮病移植物抗宿主病小鼠模型的肺和皮肤纤维化。  |  Hasegawa, T., et al. 2024. Arthritis Res Ther. 26: 94. PMID: 38702742
    8. 第三届趋化细胞因子国际研讨会趋化因子会议回顾。  |  Taub, DD. and Oppenheim, JJ. 1993. Cytokine. 5: 175-9. PMID: 8218927
    9. β 趋化因子刺激淋巴细胞细胞溶解, 增殖和淋巴因子的产生。  |  Taub, DD., et al. 1996. J Leukoc Biol. 59: 81-9. PMID: 8558072

    订购信息

    产品名称产品编号规格价格数量收藏夹

    fractalkine 抗体 (A-9)

    sc-166200
    200 µg/ml
    $316.00

    fractalkine (A-9): m-IgG3 BP-HRP 套装

    sc-550551
    200 µg Ab; 40 µg BP
    $354.00

    Could you show us immunofluorescence images used fractalkine (A-9: sc-166200) antibody?

    Asked by: kame
    This primary antibody is recommended and warrantied for IF (immunofluorescent staining of fresh or frozen tissues or cells fixed in methanol or acetone), however we are still gathering data to show on our website. Check back for updates!
    Answered by: Technical Support
    Date published: 2019-07-14

    What blocking solution should I use with fractalkine (A-9): sc-166200 monoclonal antibody for Western blot?

    Asked by: Professor Griffin
    Thank you for your question. We recommend blocking with Blotto (either TBS Blotto A: sc-2333 or TBS Blotto B: sc-2335). Our Western blot protocol can be found here: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Specific and sharp bandthis antibody was tested on human aortic smooth muscle cells, and minimal background was observed, leaving a sharp and specific band with predicted size.
    Date published: 2017-09-26
    Rated 5 out of 5 by from Produced positive Western Blot data of fullProduced positive Western Blot data of full length human recombinant fractalkine. -SCBT QC
    Date published: 2015-04-06
    Rated 5 out of 5 by from Satisfactory Western Blot data of fractalkineSatisfactory Western Blot data of fractalkine expression in Hep G2 whole cell lysate. -SCBT QC
    Date published: 2013-05-18
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    fractalkine 抗体 (A-9) is rated 5.0 out of 5 by 3.
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