Date published: 2025-9-7
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FPR2 Antibody (GM1D6) - Western Blotting - Image 35304
FPR2 抗体 (GM1D6): sc-57141. 对 AML-193 全细胞裂解液中 FPR2 的表达进行 Western 印迹分析.
FPR2 Antibody (GM1D6) - Western Blotting - Image 35304
FPR2 抗体 (GM1D6): sc-57141. 对 AML-193 全细胞裂解液中 FPR2 的表达进行 Western 印迹分析.
FPR2 Antibody (GM1D6) - Western Blotting - Image 18102
FPR2 抗体 (GM1D6): sc-57141. 在非还原条件下, 对人 PBL (A) 和 AML-193 (B) 全细胞裂解液中 FPR2 的表达进行 Western 印迹分析.
FPR2 抗体 (GM1D6): sc-57141. 对 AML-193 全细胞裂解液中 FPR2 的表达进行 Western 印迹分析.

FPR2 抗体 (GM1D6): sc-57141

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寫評論提問

说明书
  • FPR2 抗体 GM1D6 是小鼠单克隆 IgG1 κ，FPR2抗体, 在11篇文献中引用，规格为200 µg/ml
  • 免疫human物种的FPR2
  • FPR2 抗体 (GM1D6) 推荐用于WB, IP 和 FCM，检测human 来源的 FPR2 transiently expressed on the cell surface of transfected BOSC cells.
  • 抗FPR2抗体（GM1D6）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取FPR2 (GM1D6): sc-57141的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP和 1 BP-HRP">m-IgG1 BP-HRP是FPR2 Antibody (GM1D6) for WB applications. 的首选辅助检测试剂，这些试剂现与FPR2 Antibody (GM1D6) 打包提供（请参阅下面的订购信息）。

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研究信息

関連項目

额外FPR抗体，包括FPR2

FPR2抗体（GM1D6）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和流式细胞术（FCM）检测人类来源的FPR2蛋白。抗FPR2抗体（GM1D6）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。N-甲酰肽受体（FPR）家族包括FPR2，由三个成员组成：FPR、FPR-like 1（FPRL1）和FPR-like 2（FPRL2）。这些受体是免疫反应不可或缺的一部分，作为趋化性G蛋白偶联受体，具有七个跨膜结构域，主要位于吞噬性白细胞（如中性粒细胞和单核细胞）的表面。FPR2通过与多种配体结合，包括脂氧A4和N-甲酰-蛋氨酰-亮氨酰-苯丙氨酸（fMLP），在调节炎症反应和宿主防御机制中发挥着关键作用。激活后，FPR2可触发细胞迁移和钙动员，这对于有效的免疫反应至关重要。值得注意的是，FPR2与特定配体的相互作用对其功能至关重要，因为FPR2有助于调节炎症，并可能影响阿尔茨海默氏症等疾病的进展。FPR2能够调节免疫细胞活性，因此成为控制炎症和增强宿主防御的治疗干预的重要靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

FPR2 抗体 (GM1D6) 参考文献:

  1. 激活单核细胞中的趋化肽受体 FPRL1 可使趋化因子受体 CCR5 磷酸化，并减弱细胞对特定趋化因子的反应。  |  Shen, W., et al. 2000. Biochem Biophys Res Commun. 272: 276-83. PMID: 10872839
  2. 神经毒性朊病毒肽片段 PrP(106-126) 是 G 蛋白偶联受体甲酰肽受体样 1 的趋化激动剂。  |  Le, Y., et al. 2001. J Immunol. 166: 1448-51. PMID: 11160182
  3. 淀粉样蛋白（β）42 可激活 G 蛋白偶联趋化受体 FPR-like-1。  |  Le, Y., et al. 2001. J Neurosci. 21: RC123. PMID: 11160457
  4. 单核细胞向树突状细胞和巨噬细胞分化过程中甲酰肽受体样 1 表达的差异调控。  |  Yang, D., et al. 2001. J Immunol. 166: 4092-8. PMID: 11238658
  5. 合成肽 Trp-Lys-Tyr-Met-Val-Met-NH2 可通过 FPRL1/lipoxin A4 受体特异性地激活中性粒细胞，也是单核细胞表达的孤儿趋化受体 FPRL2 的激动剂。  |  Christophe, T., et al. 2001. J Biol Chem. 276: 21585-93. PMID: 11285256
  6. 甲酰肽受体的多效应作用。  |  Le, Y., et al. 2001. Cytokine Growth Factor Rev. 12: 91-105. PMID: 11312121
  7. 合成肽 MMK-1 是一种高度特异性的白细胞 FPRL1 趋化激动剂。  |  Hu, JY., et al. 2001. J Leukoc Biol. 70: 155-61. PMID: 11435499
  8. FPR2：治疗流感的新希望靶点  |  Alessi, MC., et al. 2017. Front Microbiol. 8: 1719. PMID: 28928730
  9. Annexin A1通过FPR2/ALX依赖的AMPK-mTOR途径调节小胶质细胞/巨噬细胞的极化，从而防止脑缺血再灌注损伤。  |  Xu, X., et al. 2021. J Neuroinflammation. 18: 119. PMID: 34022892
  10. FPR2塑造了免疫排斥的胰腺肿瘤微环境，并以性别依赖的方式驱动T细胞衰竭  |  He, F., et al. 2023. Cancer Res. 83: 1628-1645. PMID: 36919330
  11. 通过有偏向的 FPR2 信号传导增强排泄功能可减轻肠道炎症。  |  Wu, MY., et al. 2023. EMBO Mol Med. 15: e17815. PMID: 37994307
  12. 人类趋化受体基因集群位于 19q13.3-13.4。人类 C5a 受体基因的特征。  |  Gerard, NP., et al. 1993. Biochemistry. 32: 1243-50. PMID: 8383526

订购信息

产品名称产品编号规格价格数量收藏夹

FPR2 抗体 (GM1D6)

sc-57141
200 µg/ml
$316.00

FPR2 (GM1D6): m-IgG Fc BP-HRP 套装

sc-526894
200 µg Ab; 10 µg BP
$354.00

FPR2 (GM1D6): m-IgG1 BP-HRP 套装

sc-532267
200 µg Ab; 20 µg BP
$354.00

FPR2 抗体 (GM1D6) AC

sc-57141 AC
500 µg/ml, 25% agarose
$416.00

FPR2 抗体 (GM1D6) HRP

sc-57141 HRP
200 µg/ml
$316.00

FPR2 抗体 (GM1D6) FITC

sc-57141 FITC
200 µg/ml
$330.00

FPR2 抗体 (GM1D6) PE

sc-57141 PE
200 µg/ml
$343.00

FPR2 抗体 (GM1D6) Alexa Fluor® 488

sc-57141 AF488
200 µg/ml
$357.00

FPR2 抗体 (GM1D6) Alexa Fluor® 546

sc-57141 AF546
200 µg/ml
$357.00

FPR2 抗体 (GM1D6) Alexa Fluor® 594

sc-57141 AF594
200 µg/ml
$357.00

FPR2 抗体 (GM1D6) Alexa Fluor® 647

sc-57141 AF647
200 µg/ml
$357.00

FPR2 抗体 (GM1D6) Alexa Fluor® 680

sc-57141 AF680
200 µg/ml
$357.00

FPR2 抗体 (GM1D6) Alexa Fluor® 790

sc-57141 AF790
200 µg/ml
$357.00

Can FPR2 抗体 (GM1D6) used for IHC-P in human tissue?

Asked by: RuthFu
Thank you for your question. Anti-FPR2 Antibody (GM1D6): sc-57141 is recommended for detection of FPR2 transiently expressed on the cell surface of transfected BOSC cells. of human origin by WB, IP and FCM. We do not recommend it for immunohistochemistry.
Answered by: Tech Support Europe
Date published: 2022-03-18

您好，可以用于小鼠吗

Asked by: zxsc
感谢您的提问。FPR2 抗体 (GM1D6): sc-57141推荐检测人源的样本，在小鼠上没有检测过。Thank you for your question. FPR2 antibody (GM1D6): sc-57141 is recommended for detection of human origin samples, we didn't test it on mouse origin samples.
Answered by: Technical Service SH
Date published: 2022-02-23

Boa noite, adquirimos um anticorpo monoclonal FPR2 SC-57141 GM1D6 LOTE #E0217, queremos saber se ele é conjugado a fluoresceína.

Asked by: Maurício420
Thank you for your question. The antibody with catalog number: sc-57141, lot# E0217, is the unconjugated antibody. We do offer this antibody directly conjugated to fluorescein, and the catalog number is sc-57141 FITC.
Answered by: Technical Support
Date published: 2019-08-19

Good nigth, we got a monoclonal antibody FPR2 SC-57141 GM1D6 LOT # E0217, we want to know if it is conjugated to fluorescein.

Asked by: Maurício420
Thank you for your question. That specific catalog and lot number is not conjugated to fluorescein (FITC). The FITC conjugated antibody has the catalog number: sc-57141 FITC.
Answered by: Technical Support
Date published: 2019-06-15

Can FPR2 (GM1D6): sc-57141 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Randy McDonald
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, FPR2 (GM1D6): sc-57141 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from Marcatura specificaHo provato questo anticorpo in immunofluoresenza (1:100) su spinal cord di topo (fissato e criostatato) e funziona molto bene! Marcatura specifica e poco fondo
Date published: 2020-10-05
Rated 4 out of 5 by from Quite good antibodyWe tested FPR2 by western blotting analysis. 60 micrograms of mouse brain membrane lysates were resolved on 10% SDS-PAGE, and incubated over night with monoclonal FPR2 antibody (1:1000). Secondary antibody utilized was anti-mouse sc-2005 antibody (1:5000). FPR2 signal was detected by chemidoc (Biorad) and the signal (not fully clear) was reached after medium exposition.
Date published: 2017-07-25
Rated 5 out of 5 by from Reducing or Non-reducing!Great detection of FPR2 in Western Blot under both reducing and non-reducing conditions!
Date published: 2017-01-17
Rated 4 out of 5 by from The antibody worked pretty good on freshlyThe antibody worked pretty good on freshly isolated human monocytes and granulocytes, when blocked with 5% heat-inactivated FCS. At a dilution of 1/1000 I observed clear stainings with minimal background and no signal for the isotype control. Tests for cross reactivity in HEK cells expressing hFPR1 or hFPR3 were negative. For high-quality pictures cell had to be fixated with 3% methanol-free paraformaldehyde. In summary the antibody works quite good with good specificity so far.
Date published: 2016-04-13
Rated 5 out of 5 by from Good specificity in WB in AMLGood specificity in WB in AML-193 whole cell lysate. -SCBT QC
Date published: 2015-06-14
Rated 5 out of 5 by from Robust signal in WB in human PBL and AMLRobust signal in WB in human PBL and AML-193 whole cell lysates. -SCBT QC
Date published: 2014-07-25
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FPR2 抗体 (GM1D6) is rated 4.5 out of 5 by 6.
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